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When exposure to opioids ends, neonates may develop withdrawal symptoms [1]. Neonatal abstinence syndrome (NAS), also referred to as neonatal opioid withdrawal syndrome, can be subdivided into primary NAS due to prenatal opioid abuse by (or treatment of) the mother, and iatrogenic NAS (i NAS) when neonates are treated with opioids. Primary NAS may develop in more than 90% of infants after intrauterine opiate exposure [2].
JMIR Pediatr Parent 2024;7:e50575
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The medical treatment of withdrawal is a critical target in opioid treatment—the National Institute on Drug Abuse identified finding new treatments for opioid use disorders as its highest priority [8].
Clinicians use a variety of treatments for opioid withdrawal symptoms. Currently, opioid agonists such as methadone and buprenorphine are the most common treatments for opioid use disorder, and these are often tapered, during which time withdrawal symptoms may occur.
JMIR Form Res 2022;6(3):e33919
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From 2000 to 2016, the United States experienced a seven-fold increase in neonatal abstinence syndrome (NAS) [1,2], also known as neonatal opioid withdrawal syndrome (NOWS) [3,4]. NAS is a postnatal withdrawal syndrome most commonly caused by prenatal opioid exposure [5]. An infant is born every 15 minutes with signs of NAS, and total hospital costs for NAS-related births exceeded US $500 million in 2014 in the United States [2].
JMIR Res Protoc 2021;10(9):e25387
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