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Evaluating the Acceptability and Utility of a Personalized Wellness App (Aspire2B) Using AI-Enabled Digital Biomarkers: Engagement Enhancement Pilot Study

Evaluating the Acceptability and Utility of a Personalized Wellness App (Aspire2B) Using AI-Enabled Digital Biomarkers: Engagement Enhancement Pilot Study

To further personalize the experience of Aspire2 B, participants were encouraged to answer more questions covering aspects like sleep quality, physical activity, and dietary intake, although these were not mandatory (refer to Optional Onboarding Questions section). From these responses, subjects were assigned to one of three challenges, that are (1) nutrition, (2) movement, (3) sleep based on set criteria (eg, those reporting poor sleep quality were placed in sleep challenge).

Calissa J Leslie-Miller, Shellen R Goltz, Pamela L Barrios, Christopher C Cushing, Teena Badshah, Corey T Ungaro, Shankang Qu, Yulia Berezhnaya, Tristin D Brisbois

JMIR Form Res 2025;9:e63471

Perceptions of the Use of Mobile Apps to Assess Sleep-Dependent Memory in Older Adults With Subjective and Objective Cognitive Impairment: Focus Group Approach

Perceptions of the Use of Mobile Apps to Assess Sleep-Dependent Memory in Older Adults With Subjective and Objective Cognitive Impairment: Focus Group Approach

In this study, poorer SDM was linked to having greater sleep apnea severity for older adults without MCI. In contrast, for those with MCI, poorer performance was associated with decreased sleep spindle duration and smaller hippocampal subfield size. As various age-related sleep changes occur both naturally [7] and with neurodegenerative diseases [8,9], it is crucial to understand how these alterations impact SDM.

Aaron Lam, Simone Simonetti, Angela D'Rozario, David Ireland, DanaKai Bradford, Jurgen Fripp, Sharon L Naismith

JMIR Aging 2025;8:e68147

Association Between Internet Use and Sleep Health Among Middle-Aged and Older Chinese Individuals: Nationwide Longitudinal Study

Association Between Internet Use and Sleep Health Among Middle-Aged and Older Chinese Individuals: Nationwide Longitudinal Study

Based on this, we hypothesize that internet use may be associated with a reduced risk of sleep problems, including poor sleep quality and abnormal sleep duration, in middle-aged and older adults. To test this hypothesis, we examined both cross-sectional and longitudinal associations between internet use or internet frequency and sleep quality, as well as between internet use or internet frequency and sleep duration.

Xueqin Li, Jin Liu, Ning Huang, Wanyu Zhao, Hongbo He

J Med Internet Res 2025;27:e71030

Effect of Continuous Positive Airway Pressure or Positional Therapy Compared to Control for Treatment of  Obstructive Sleep Apnea on the Development of Gestational Diabetes Mellitus in Pregnancy: Protocol for Feasibility Randomized Controlled Trial

Effect of Continuous Positive Airway Pressure or Positional Therapy Compared to Control for Treatment of Obstructive Sleep Apnea on the Development of Gestational Diabetes Mellitus in Pregnancy: Protocol for Feasibility Randomized Controlled Trial

Data collection will include demographic, clinical and physical details, sleep questionnaire responses, sleep study data, maternal pathology, fetal scans, birth details, maternal and fetal clinical outcomes, sleep therapy compliance, and therapy acceptance questionnaires. We used the SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) checklist when writing our protocol [30], which can be found in Multimedia Appendix 3.

Frances Clements, Hima Vedam, Yewon Chung, John Smoleniec, Colin Sullivan, Renuka Shanmugalingam, Annemarie Hennessy, Angela Makris

JMIR Res Protoc 2025;14:e51434

Effects of Using a Smart Bassinet on the Mental Health of Military-Affiliated Pregnant Women: Protocol for a Randomized Controlled Sleep Health and Mood in Newly Expectant Military Mothers (SHINE) Trial

Effects of Using a Smart Bassinet on the Mental Health of Military-Affiliated Pregnant Women: Protocol for a Randomized Controlled Sleep Health and Mood in Newly Expectant Military Mothers (SHINE) Trial

Mothers who report poor infant sleep behavior have significantly more depressive symptoms than mothers who report good infant sleep [35-37]. There is some evidence that maternal sleep quality is a mediator of this relationship [35]. Persistent, rather than transient, infant sleep issues contribute to maternal depression, poor sleep, and poor family functioning well into toddlerhood [33,38,39].

Michele L Okun, Jennifer L Payne, Lauren M Osborne, Leilani Feliciano, Andrew Lac

JMIR Res Protoc 2025;14:e66439

Detecting Sleep/Wake Rhythm Disruption Related to Cognition in Older Adults With and Without Mild Cognitive Impairment Using the myRhythmWatch Platform: Feasibility and Correlation Study

Detecting Sleep/Wake Rhythm Disruption Related to Cognition in Older Adults With and Without Mild Cognitive Impairment Using the myRhythmWatch Platform: Feasibility and Correlation Study

Twenty-four-hour sleep/wake characteristics, which are objectively measurable using accelerometer-containing devices, are related to both dementia biomarkers and dementia risk. Prior studies have shown that sleep/wake rhythm disruption, including fragmentation of 24-hour sleep/wake rhythms, temporally precedes the incidence of mild cognitive impairment (MCI) and dementia [1,2]. Even among adults with normal cognition, rhythm fragmentation correlates with greater brain amyloid deposition [3,4].

Caleb D Jones, Rachel Wasilko, Gehui Zhang, Katie L Stone, Swathi Gujral, Juleen Rodakowski, Stephen F Smagula

JMIR Aging 2025;8:e67294

Effectiveness of Digital Lifestyle Interventions on Depression, Anxiety, Stress, and Well-Being: Systematic Review and Meta-Analysis

Effectiveness of Digital Lifestyle Interventions on Depression, Anxiety, Stress, and Well-Being: Systematic Review and Meta-Analysis

To be included in this systematic review and meta-analysis, studies needed to meet the following criteria: (1) involve adults (aged ≥18 years) of any health status and (2) include a digitally delivered lifestyle intervention targeting physical activity, diet, sleep, or any combination thereof.

Jacinta Brinsley, Edward J O'Connor, Ben Singh, Grace McKeon, Rachel Curtis, Ty Ferguson, Georgia Gosse, Iris Willems, Pieter-Jan Marent, Kimberley Szeto, Joseph Firth, Carol Maher

J Med Internet Res 2025;27:e56975

Development of a Voice-Activated Virtual Assistant to Improve Insomnia Among Young Adult Cancer Survivors: Mixed Methods Feasibility and Acceptability Study

Development of a Voice-Activated Virtual Assistant to Improve Insomnia Among Young Adult Cancer Survivors: Mixed Methods Feasibility and Acceptability Study

Participants were instructed to engage with the prototype system twice daily for 14 days, including entering sleep logs, receiving smart speaker–delivered education about relevant content (eg, sleep hygiene, relaxation strategies), and reviewing personalized data regarding screen time use.

Hunter Groninger, Hannah Arem, Lylian Ayangma, Lisa Gong, Eric Zhou, Daniel Greenberg

JMIR Form Res 2025;9:e64869

Monitoring Sleep Quality Through Low α-Band Activity in the Prefrontal Cortex Using a Portable Electroencephalogram Device: Longitudinal Study

Monitoring Sleep Quality Through Low α-Band Activity in the Prefrontal Cortex Using a Portable Electroencephalogram Device: Longitudinal Study

Sleep is a fundamental behavior closely related to daily life, and sleep quality plays a crucial role in human health [1-4]. Poor sleep quality often leads to various types of physical ailments [5-7]. Previous studies have conducted systematic research across different species (flies [8], rodents [9-14], cats [15,16], nonhuman primates [17], and humans [18-21]) to characterize the neural mechanisms across multiple stages of sleep.

Chuanliang Han, Zhizhen Zhang, Yuchen Lin, Shaojia Huang, Jidong Mao, Weiwen Xiang, Fang Wang, Yuping Liang, Wufang Chen, Xixi Zhao

J Med Internet Res 2025;27:e67188

Associations Between Sleep Duration and Activity of Daily Living Disability Among Older Adults in China: Cross-Sectional Study

Associations Between Sleep Duration and Activity of Daily Living Disability Among Older Adults in China: Cross-Sectional Study

This report emphasizes that sleep loss is an extremely important risk factor for mental health issues. At present, the relationship between sleep duration and ADL disability has received much attention [13]. A longitudinal observational study suggested that short sleep duration during inpatient rehabilitation might be against greater functional ability at discharge among individuals with acute stroke [14].

Huimin Fan, Weijie Yu, Hongguo Rong, Xiaokun Geng

Interact J Med Res 2025;14:e65075