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Understanding the Experiences of Patients With Pancreatic Cancer: Quantitative Analysis of the Pancreatic Cancer Action Network Patient Registry

Understanding the Experiences of Patients With Pancreatic Cancer: Quantitative Analysis of the Pancreatic Cancer Action Network Patient Registry

Another publication explored prediagnosis pain and symptom management, with data suggesting that patients who experience pain before their pancreatic cancer diagnosis had a higher likelihood of being diagnosed with metastatic disease, had more frequent and more intense symptoms, and faced more challenges with pain management throughout their experience with pancreatic cancer [8]. Pancreatic cancer is one of the deadliest cancer diagnoses.

Allison Rosenzweig, Sydney Rathjens, Kawther Abdilleh, Dennis Ladnier, Fatima Zelada-Arenas, Sudheer Doss, Lynn M Matrisian

J Particip Med 2025;17:e65046

The Effects of Acupoint Stimulation Combined With Transcutaneous Electrical Nerve Stimulation on Labor Pain: Protocol for a Stepped Wedge Cluster Randomized Controlled Trial

The Effects of Acupoint Stimulation Combined With Transcutaneous Electrical Nerve Stimulation on Labor Pain: Protocol for a Stepped Wedge Cluster Randomized Controlled Trial

Childbirth pain is widely regarded as one of the most intense forms of pain, often cited by women as the most severe pain they have ever experienced [1]. Approximately 60% of primiparous women report experiencing severe or extremely severe labor pain [2], with 74.2% scoring 8 or higher on the pain perception scale [3]. The intensity of labor pain can lead to anxiety, fear, and tension, which in turn diminishes pain tolerance and exacerbates the cycle of pain.

Yiyun Gu, Xiaojiao Wang, Chunxiang Zhu, Hui Min, Jialu Zhang, Liping Mao, Hua Gao, Hangyun Sun, Xinli Zhu, Chunyi Gu

JMIR Res Protoc 2025;14:e63050

Factors Influencing Virtual Reality as a Distraction Tool for Venipuncture in Children: Observational Pilot Feasibility Study

Factors Influencing Virtual Reality as a Distraction Tool for Venipuncture in Children: Observational Pilot Feasibility Study

VR utilizes the notion that attention is finite and can be diverted from pain and discomfort and therefore serves as effective cognitive distraction [2]. VR provides immersive engagement, isolating users from the real-world environment and associated pain and anxiety [1]. VR has been used as a nonpharmacological adjunct in pediatric care in a variety of clinical scenarios [3-9].

Chris Worth, Leyi Yang, Catherine Fullwood, Indraneel Banerjee

JMIR Serious Games 2025;13:e66656

Digital, Personalized Clinical Trials Among Older Adults, Lessons Learned From the COVID-19 Pandemic, and Directions for the Future: Aggregated Feasibility Data From Three Trials Among Older Adults

Digital, Personalized Clinical Trials Among Older Adults, Lessons Learned From the COVID-19 Pandemic, and Directions for the Future: Aggregated Feasibility Data From Three Trials Among Older Adults

Personalized trials conducted among older adult cohorts have demonstrated improvement in outcomes across a range of conditions, including chronic pain [30], depression [31], physical activity [32], cancer [33], and the experience of palliative care [34]. While a patient-focused structure in a personalized trial has always been appealing, the uptake for such trials in practice and research has been low [35].

Lindsay Arader, Danielle Miller, Alexandra Perrin, Frank Vicari, Ciaran P Friel, Elizabeth A Vrany, Ashley M Goodwin, Mark Butler

J Med Internet Res 2025;27:e54629

Cooperative Virtual Reality Gaming for Anxiety and Pain Reduction in Pediatric Patients and Their Caregivers During Painful Medical Procedures: Protocol for a Randomized Controlled Trial

Cooperative Virtual Reality Gaming for Anxiety and Pain Reduction in Pediatric Patients and Their Caregivers During Painful Medical Procedures: Protocol for a Randomized Controlled Trial

In this study, we investigate whether targeted distraction from anxiety- and pain-inducing medical procedures through cooperative VR gaming can reduce experienced pain and anxiety while fostering well-being for both the patients and their caregivers. A list of our hypotheses is presented in Textbox 1. Hence, the primary outcome of the study is a reduction in pain and anxiety ratings of the patient (hypothesis 1) as well as an improvement in the caregiver’s emotional experience (hypothesis 2).

Stefan Liszio, Franziska Bäuerlein, Jens Hildebrand, Carolin van Nahl, Maic Masuch, Oliver Basu

JMIR Res Protoc 2025;14:e63098

Predicting Clinical Outcomes at the Toronto General Hospital Transitional Pain Service via the Manage My Pain App: Machine Learning Approach

Predicting Clinical Outcomes at the Toronto General Hospital Transitional Pain Service via the Manage My Pain App: Machine Learning Approach

Pain interference refers to the impact pain has on engagement in daily activities and participation [22]. It is related to the perceived severity of pain [23] and is considered a key aspect of the pain experience and a primary outcome in many clinical trials [24]. It is an informative measure from a clinical treatment and pain management standpoint that focuses on patients’ daily functioning rather than pain intensity itself [25-27].

James Skoric, Anna M Lomanowska, Tahir Janmohamed, Heather Lumsden-Ruegg, Joel Katz, Hance Clarke, Quazi Abidur Rahman

JMIR Med Inform 2025;13:e67178

Mobile App-Based Interactive Care Plan for Migraine: Survey Study of Usability and Improvement Opportunities

Mobile App-Based Interactive Care Plan for Migraine: Survey Study of Usability and Improvement Opportunities

level of interest and motivation to track on a daily basis, respondents were somewhat or very interested in tracking personal observations or comments in free text (41/52, 78.8%), medication treatment (43/52, 82.7%), response to medication (39/56, 69.6%), class of medication treatment chosen from a list (36/52, 69.2%), functional impairment graded mild, moderate, or severe (39/56, 69.6%), type of function impaired including work, school, family, personal (35/53, 66%), headache day (40/54, 74.1%), and headache pain

Nathan P Young, Jennifer I Stern, Stephanie J Steel, Jon O Ebbert

JMIR Form Res 2025;9:e66763

Creation of the ECHO Idaho Podcast: Tutorial and Pilot Assessment

Creation of the ECHO Idaho Podcast: Tutorial and Pilot Assessment

The purpose of this paper was to present the development and implementation process of the ECHO Idaho “Something for the Pain” podcast’s inaugural season, as well as to discuss the preliminary findings regarding the reach of the podcast, lessons learned, and proposed future uses of this innovative platform.

Ryan Wiet, Madeline P Casanova, Jonathan D Moore, Sarah M Deming, Russell T Baker Jr

JMIR Med Educ 2025;11:e55313

Behavioral Therapy–Based Digital Interventions for Treating Osteoarthritis: Systematic Review and Meta-Analysis

Behavioral Therapy–Based Digital Interventions for Treating Osteoarthritis: Systematic Review and Meta-Analysis

Some have confirmed that CBT is beneficial for pain improvement [20-22] and that BCT could enhance physical activity compliance in patients with lower extremity OA [23-25], while others have argued that CBT has no effect on patients who catastrophize about pain or has only a small positive effect on pain [12,26]. The increased prevalence of OA has resulted in increasing demand for therapists [27].

Beiyao Zhu, Dian Zhu, Xiao'ao Xue, Hongyi Yang, Shurong Zhang

J Med Internet Res 2025;27:e56227

Neurobiological Mechanisms of Enhanced Pain-Relieving Transcutaneous Electrical Nerve Stimulation via Visuo-Tactile Stimulation in Immersive Virtual Reality: Randomized Controlled Trial

Neurobiological Mechanisms of Enhanced Pain-Relieving Transcutaneous Electrical Nerve Stimulation via Visuo-Tactile Stimulation in Immersive Virtual Reality: Randomized Controlled Trial

The application of transcutaneous electrical nerve stimulation (TENS) has been widely used for pain management, such as postoperative pain, labor pain, and chronic neck pain [1-3]. Low-intensity and high-frequency (50-100 Hz) electrical pulses, a form of TENS, can activate large-diameter A fibers and inhibit the nociceptive volley transmitted via small-diameter A and C fibers that innervate spatially adjacent skin areas [4].

Chenxi Wang, Lanqi Gao, Chuan Zhang, Jun Li, Jixin Liu

J Med Internet Res 2025;27:e63137