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The primary objectives of this pilot study were to evaluate the efficacy of this system in improving exercise capacity and adherence through continuous and interactive communication between health care providers and patients and to clarify the synergistic effects of OLC on the use of wearable devices. We hypothesized that the combination of wearable devices and OLC would result in greater improvements in exercise capacity and adherence than those achieved through the use of wearable devices alone.
JMIR Mhealth Uhealth 2025;13:e63797
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Exercise has been acknowledged as a nonpharmacological intervention modality for the treatment and prevention of musculoskeletal disorders, including osteoarthritis, osteoporosis, back pain, and rheumatoid arthritis [3]. Specifically, it has been empirically demonstrated that participating in appropriate physical exercise while being monitored by a physiotherapist effectively maintains physical health and athletic ability [4].
JMIR Mhealth Uhealth 2025;13:e63022
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Numerous studies have demonstrated the effectiveness of exercise interventions in preventing falls and improving physical function in older adults [8,9]. Each type of exercise (ie, resistance, aerobic, and balance training) has specific benefits, and incorporating high-challenge balance training in exercise programs is particularly emphasized for fall prevention [9,10].
JMIR Mhealth Uhealth 2025;13:e64458
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Participants will then be randomized by an independent investigator to either exercise intervention arm A or exercise intervention and control arm B using a computer-generated random number table.
After the baseline visit 1 examination, the A-arm will undergo 12 weeks of a progressive aerobic exercise intervention protocol, after which the clinical examination will be repeated.
JMIR Res Protoc 2025;14:e67570
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However, systematic reviews and meta-analyses reveal that current health promotion studies predominantly focus on single exercise modalities, yielding inconsistent effects on physical function and lacking in-depth exploration of multicomponent exercise interventions, particularly in practical applications and comprehensive outcome assessments [4,5,7].
Interact J Med Res 2025;14:e65213
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Intensity: moderate intensity exercise as indicated by a rating of perceived exertion of 5 to 7 on the Borg 0‐10 scale.
Time: as many minutes of exercise as possible that could be fit within students’ school schedules (eg, either within their physical education period or a study hall or gap period).
Type: VR exercise at home or in the school setting, at the choice of the caregiver and participant.
JMIR Form Res 2025;9:e65801
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Group 1 is the closed kinetic exercise group, group 2 is the proprioceptive exercise group, and group 3 is the control group. Participants in group 1 and group 2 will receive exercise training twice a week for 12 weeks for a total of 24 sessions of 45 minutes each. The control group will not receive any intervention. Exercise training will continue under the supervision of the physiotherapist. Patients will have completed their factor replacement on the day of exercise.
JMIR Res Protoc 2025;14:e66770
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Reference 73: Patients' acceptability of self-selected digital health services to support diet and exerciseexercise
J Med Internet Res 2025;27:e54629
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We also included a smaller intervention group of participants with PFOS
Participants randomized into the zone 2 physical activity arm complete a Cardiopulmonary Exercise Test (CPET) before starting their intervention. The CPET uses a mouthpiece and external sensors to measure the heart rate and other cardiovascular health indicators of the individual while they engage in mild exercise on a stationary bicycle.
JMIR Res Protoc 2025;14:e67120
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