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Twin-twin transfusion syndrome (TTTS) results from unbalanced vascular communications in a shared placenta between monochorionic diamniotic (MCDA) twins. Bidirectional vascular communications are present in up to 95% of MCDA twins and allow for a single, shared circulatory system [1]. However, in 9%‐15% of MCDA twins, unbalanced vascular communications produce a pathological state in which one fetus (the donor twin) overtransfuses the cotwin (the recipient) [2,3].
JMIR Pediatr Parent 2024;7:e60039
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This study is a national, German-wide prospective cohort study investigating twin siblings with at least one having a CHD. They are registered in the National Register for Congenital Heart Defects (NRCHD), the largest register for patients with CHD in Europe [17]. The inclusion takes place by written information sheets and an invitation to participate (see Figure 1).
JMIR Res Protoc 2021;10(5):e26404
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