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Adherence to Therapy Using Neurostimulation Devices in the Treatment of Pediatric Attention-Deficit/Hyperactivity Disorder: Extraclinical Study

Adherence to Therapy Using Neurostimulation Devices in the Treatment of Pediatric Attention-Deficit/Hyperactivity Disorder: Extraclinical Study

The standard of care for pediatric ADHD varies with age and intensity of symptoms but is likely to include a combination of school accommodations, behavioral therapy, and medication [2,7,8]. For very young patients and/or patients with less-inhibiting symptoms, behavioral therapy is likely to be considered first [9].

Allyson Calandro, Saurabh Biswas, Anthony Guiseppi-Elie

JMIR Neurotech 2025;4:e68736

Scalable Precision Psychiatry With an Objective Measure of Psychological Stress: Prospective Real-World Study

Scalable Precision Psychiatry With an Objective Measure of Psychological Stress: Prospective Real-World Study

Thus, the only assumption used by the algorithm is that the forms of therapy that are most effective for a given patient at one point in time will reliably predict the forms of therapy that will be most effective for the same patient at a later point in time. A total of 3 types of pre- and postsession data were available to provide an evaluation of historical efficacy: ∆OSL, ∆SRS, and ∆SRM (as explained above within the “Materials and Variables” section).

Helena Wang, Norman Farb, Bechara Saab

J Med Internet Res 2025;27:e56086

Evaluating the Quality of Psychotherapy Conversational Agents: Framework Development and Cross-Sectional Study

Evaluating the Quality of Psychotherapy Conversational Agents: Framework Development and Cross-Sectional Study

In May 2024, we indexed both sites using the search feature to emulate what an end-user may experience with the following search terms: “therapy,” “anxiety,” “depression,” “mental health,” “therapist,” and “psychologist.” We excluded GPTs that emulated a human (such as a GPT that impersonates Sigmund Freud), those geared toward mental health care professionals (eg, a GPT that helps clinicians write medical notes), and those focused on sex or that were sex therapy related.

Kunmi Sobowale, Daniel Kevin Humphrey

JMIR Form Res 2025;9:e65605

Effectiveness of Information and Communication Technology–Based Cognitive Behavioral Therapy Using the Smart Sleep App on Insomnia in Older Adults: Randomized Controlled Trial

Effectiveness of Information and Communication Technology–Based Cognitive Behavioral Therapy Using the Smart Sleep App on Insomnia in Older Adults: Randomized Controlled Trial

The most common treatments for insomnia include medications and cognitive behavioral therapy for insomnia (CBT-I) [6]. Pharmacological treatments are widely used for insomnia in clinical settings. However, pharmacotherapy may not be appropriate for older people or those with various comorbidities because of drug-drug interactions and side effects [7].

ChanHee Kim, Yeonhee Lee, Seung-Gul Kang, Seon-Heui Lee

J Med Internet Res 2025;27:e67751

Effectiveness of Digital Behavioral Activation Interventions for Depression and Anxiety: Systematic Review and Meta-Analysis

Effectiveness of Digital Behavioral Activation Interventions for Depression and Anxiety: Systematic Review and Meta-Analysis

Various psychotherapeutic treatments help alleviate symptoms of depression and anxiety, including psychosocial education, mindfulness, and cognitive behavioral therapy (CBT) [10]. CBT is a widely used and effective behavioral treatment shown to reduce depression symptoms and anxiety [11-13]. CBT is a structured, goal-oriented talk therapy that helps individuals recognize how their beliefs may influence their actions, unlearn negative thoughts, and replace them with healthier thinking patterns and habits.

Eric Jia, Jushawn Macon, Michelle Doering, Joanna Abraham

J Med Internet Res 2025;27:e68054

Mindfulness-Based Cognitive Therapy for Life (MBCT-L) Versus Stress Reduction Psychoeducation (SRP) for the Improvement of Mental Well-Being in Health Care and Other Public Sector Staff: Protocol for the Well at Work Randomized Controlled Trial

Mindfulness-Based Cognitive Therapy for Life (MBCT-L) Versus Stress Reduction Psychoeducation (SRP) for the Improvement of Mental Well-Being in Health Care and Other Public Sector Staff: Protocol for the Well at Work Randomized Controlled Trial

Mindfulness-Based Cognitive Therapy for Life (MBCT-L) [9] is a newer, third-wave intervention, which is increasingly being implemented in the NHS and other public sector services. MBCT-L borrows its premises from the standard Mindfulness-Based Cognitive Therapy (MBCT) variant [10,11], which is a NICE-recommended treatment option for recurrent and mild to moderate acute depression [12], and is also included in clinical guidelines as a relapse prevention option in other countries [13-15].

Elena Nixon, Shireen Patel, Priya Patel, James Roe, Neil Nixon, Tim Sweeney, Paul Bernard, Clara Strauss, Michael P Craven, Sam Malins, Rob Goodwin, Laurence Astill Wright, Boliang Guo, Richard Morriss

JMIR Res Protoc 2025;14:e67695

Impact of Tai Chi Therapy on Fatigue and Cognitive Function in Individuals With Chronic Fatigue Syndrome: Protocol for a Pilot Randomized Controlled Trial

Impact of Tai Chi Therapy on Fatigue and Cognitive Function in Individuals With Chronic Fatigue Syndrome: Protocol for a Pilot Randomized Controlled Trial

In recent years, exercise therapy has emerged as a research hot spot in CFS treatment, showing notable benefits in symptom improvement. Traditional Qigong, in particular, offers several advantages, including the regulation of the body, breath, and mind. Previous studies [17,18] have shown that Qigong can relieve both overall fatigue and psychological fatigue, making it an effective treatment for CFS.

Bin Wang, Xiaodong Zhang, Ping Lu, Pingping Sun, Tianxiang He

JMIR Res Protoc 2025;14:e65958

Expert and Interdisciplinary Analysis of AI-Driven Chatbots for Mental Health Support: Mixed Methods Study

Expert and Interdisciplinary Analysis of AI-Driven Chatbots for Mental Health Support: Mixed Methods Study

Wysa, on the other hand, is explicitly presented as a “clinically validated AI” capable of engaging people in “warm and friendly conversations” informed by “cognitive-behavioral techniques dialectical behavioral therapy, meditation, breathing, yoga, motivational interviewing, and microactions to help you build mental resilience skills and feel better” [37]. As of 2024, Wysa makes clear its limitations, stating it cannot help in crisis or in cases of severe mental health concerns [44].

Kayley Moylan, Kevin Doherty

J Med Internet Res 2025;27:e67114

Assessment of an App-Based Sleep Program to Improve Sleep Outcomes in a Clinical Insomnia Population: Randomized Controlled Trial

Assessment of an App-Based Sleep Program to Improve Sleep Outcomes in a Clinical Insomnia Population: Randomized Controlled Trial

Consequently, behavioral and psychological interventions, such as cognitive behavioral therapy for insomnia (CBT-I) [15] and mindfulness [16,17], have gained popularity for treating sleep disturbances and insomnia, with a robust body of literature supporting their efficacy [15-18].

Walter Staiano, Christine Callahan, Michelle Davis, Leah Tanner, Chelsea Coe, Sarah Kunkle, Ulrich Kirk

JMIR Mhealth Uhealth 2025;13:e68665

The Efficacy of Digital Interventions on Adherence to Oral Systemic Anticancer Therapy Among Patients With Cancer: Systematic Review and Meta-Analysis

The Efficacy of Digital Interventions on Adherence to Oral Systemic Anticancer Therapy Among Patients With Cancer: Systematic Review and Meta-Analysis

Oral systemic anticancer therapy (SACT) has become increasingly accessible over the past 10 years, comprising 25% of oncology prescriptions globally [8] due to the advantages of being noninvasive, less intrusive, and more convenient [9]. However, they are prone to nonadherence as patients take medicines away from the medical setting. Many patients struggle to adhere to daily oral SACTs, with an adherence rate varying from 16% to 100% based on the settings and types of medicine [10].

Wan-Chuen Liao, Fiona Angus, Jane Conley, Li-Chia Chen

JMIR Cancer 2025;11:e64208