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A call has been made to understand the moderators and mediators involved in predicting benefits from psychological treatments [6], in particular, to determine factors that could be targeted in different or alternative interventions that could be offered to those at risk of low treatment response [7].
JMIR Pediatr Parent 2023;6:e42399
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To examine both forms of cognitive activity, measured as worry and work-related rumination, as potential mediators of interventional effects on the primary outcome at T2, parallel multiple mediation analysis was conducted using the PROCESS software for SPSS (model 4), with bias-corrected bootstraps based on 10,000 bootstrap samples [68]. To establish temporal precedence, the postintervention scores of the mediators and 6-month follow-up scores for the primary outcome were used.
J Med Internet Res 2020;22(1):e13346
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To investigate mediators of treatment outcome, at least 3 measurement moments are needed to establish a timeline of mediators and outcomes.
Research on Web-based CBT to treat depressive symptoms in PLWH is scarce. As far as we know, no studies were conducted on mediators of Web-based CBT for depressive symptoms in PLWH, although potential mediators of CBT (face-to-face and Web-based) for people with depressive symptoms in general have been investigated in the last decade.
JMIR Ment Health 2019;6(8):e12711
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