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The objective of this study is to compare the efficacy and safety profiles of dienogest 1 mg/day and 2 mg/day in patients with endometriosis-associated dysmenorrhea over a 48-week treatment period. We hypothesize that dienogest can effectively alleviate menstrual pain in these patients without significant adverse effects.
JMIR Res Protoc 2025;14:e66246
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Menstruation is a physical symptom that occurs in women of reproductive age and can bring pain or cramps during the menstrual period (hereafter dysmenorrhea) and premenstrual syndrome (PMS), which includes symptoms experienced before the menstrual period. Menstruation significantly impacts women's daily lives when their academic and social activities are most active [1-5], with 85.4% experiencing dysmenorrhea, and 38.4% reporting reduced activity due to menstrual pain [6].
J Med Internet Res 2024;26:e53146
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Dysmenorrhea, or menstrual pain, is experienced by over 90% of adolescents who menstruate and has been associated with mental health symptoms, nonsuicidal self-injury, and decreased quality of life [1-3]. For a quarter of these youth, the severity of their pain prevents them from engaging in daily activities and contributes to school absenteeism [4]. Increasingly, it is recognized that persistent, unmanaged dysmenorrhea may lead to the development of chronic pain [5,6].
JMIR Pediatr Parent 2024;7:e54658
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International ResearchKit App for Women with Menstrual Pain: Development, Access, and Engagement
Primary dysmenorrhea is defined as menstrual pain in the absence of underlying pathology, with the pain commonly starting within 3 years of menarche (the first menstrual period) [8]. A characteristic symptom of primary dysmenorrhea is crampy, colicky spasms of pain below the belly button, occurring within 8 to 72 hours of menstruation and peaking within the first few days as menstrual flow increases [9].
JMIR Mhealth Uhealth 2020;8(2):e14661
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