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Prediction of Insulin Resistance in Nondiabetic Population Using LightGBM and Cohort Validation of Its Clinical Value: Cross-Sectional and Retrospective Cohort Study

Prediction of Insulin Resistance in Nondiabetic Population Using LightGBM and Cohort Validation of Its Clinical Value: Cross-Sectional and Retrospective Cohort Study

As a condition that can exist before the onset of type 2 diabetes, IR is not only one of the key mechanisms underlying the development of diabetes but also a major risk factor for various diseases [2]. According to the International Diabetes Federation, it is estimated that by 2045, there will be 783.2 million people affected globally, with the vast majority having type 2 diabetes [3]. Furthermore, IR is even more common.

Ting Peng, Rujia Miao, Hao Xiong, Yanhui Lin, Duzhen Fan, Jiayi Ren, Jiangang Wang, Yuan Li, Jianwen Chen

JMIR Med Inform 2025;13:e72238

Recommendations for Designing a Digital Health Tool for Blindness Prevention Among High-Risk Diabetic Retinopathy Patients: Qualitative Focus Group Study of Adults With Diabetes

Recommendations for Designing a Digital Health Tool for Blindness Prevention Among High-Risk Diabetic Retinopathy Patients: Qualitative Focus Group Study of Adults With Diabetes

One study tailored the design of a digital tool specifically for low-income Arabic individuals living in Israel, however, their intervention provided only diabetes-related dietary knowledge [18]. There is a clear and urgent need for content and features to improve DR screening rates and provide comprehensive diabetes-related support. Individuals with diabetes often describe the mental toll of living with diabetes. Adverse psychological experiences are documented in the literature.

Akua Frimpong, Alvaro Granados, Thomas Chang, Julia Fu, Shannan G Moore, Serina Applebaum, Bolatito Adepoju, Mahima Kaur, Vignesh Hari Krishnan, Amanda Levi, Terika McCall, Kristen Harris Nwanyanwu

JMIR Form Res 2025;9:e65893

The Use of AI-Powered Thermography to Detect Early Plantar Thermal Abnormalities in Patients With Diabetes: Cross-Sectional Observational Study

The Use of AI-Powered Thermography to Detect Early Plantar Thermal Abnormalities in Patients With Diabetes: Cross-Sectional Observational Study

Diabetes affects 1 in 10 adults worldwide (537 million) [1]. This number is predicted to rise to 643 million by 2030 and 783 million by 2045. In the Middle East and North Africa region, the prevalence is higher as it affects 1 in 6 adults (73 million) [1]. Despite advances in medical therapies, the prevalence of diabetes mellitus and diabetes-related complications continues to rise [2]. Diabetic foot problems are among the most debilitating complications of diabetes mellitus.

Meshari F Alwashmi, Mustafa Alghali, AlAnoud AlMogbel, Abdullah Abdulaziz Alwabel, Abdulaziz S Alhomod, Ibrahim Almaghlouth, Mohamad-Hani Temsah, Amr Jamal

JMIR Diabetes 2025;10:e65209

Evaluating Digital Health Solutions in Diabetes and the Role of Patient-Reported Outcomes: Targeted Literature Review

Evaluating Digital Health Solutions in Diabetes and the Role of Patient-Reported Outcomes: Targeted Literature Review

In Pub Med, the PROs name and “diabetes” were used to search for relevant results and in Clinical Trials.gov the PROs name and “type 1 diabetes” and “type 2 diabetes” were used. Then, to determine associations with DHS, PROs name and “diabetes” were used in conjunction with “mobile application,” “telemedicine,” “telehealth,” “health digital solutions,” and “e-health” in Pub Med.

Paco Cerletti, Michael Joubert, Nick Oliver, Saira Ghafur, Pasquale Varriale, Ophélie Wilczynski, Marlene Gyldmark

JMIR Diabetes 2025;10:e52909

The Effect of a Mobile App (eMOM) on Self-Discovery and Psychological Factors in Persons With Gestational Diabetes: Mixed Methods Study

The Effect of a Mobile App (eMOM) on Self-Discovery and Psychological Factors in Persons With Gestational Diabetes: Mixed Methods Study

Gestational diabetes mellitus (GDM) is an increasing issue in maternal health care as it affects approximately 14% of pregnant individuals globally [1]. GDM increases the risk of developing type 2 diabetes and cardiovascular diseases [2,3], and also predisposes the child to adulthood obesity and type 2 diabetes [4].

Sini Määttänen, Saila Koivusalo, Hanna Ylinen, Seppo Heinonen, Mikko Kytö

JMIR Mhealth Uhealth 2025;13:e60855

Enhancing Antidiabetic Drug Selection Using Transformers: Machine-Learning Model Development

Enhancing Antidiabetic Drug Selection Using Transformers: Machine-Learning Model Development

Diabetes affects 529 million people worldwide, with 1 in every 10 adults experiencing the condition [1]. Patients with diabetes receive care from primary care physicians, not endocrinologists, in many areas including the United States, Europe [2], and Japan [3]. This is particularly concerning in the United States, where the endocrinologist shortage is significant: the population-to-endocrinologist ratio within 20 miles was 29,887:1 for adults aged 18‐64.

Hisashi Kurasawa, Kayo Waki, Tomohisa Seki, Eri Nakahara, Akinori Fujino, Nagisa Shiomi, Hiroshi Nakashima, Kazuhiko Ohe

JMIR Med Inform 2025;13:e67748

The Relationship Between Sleep Disorders and Combination of Diabetes and Sarcopenia in Adults Aged 45 Years or Older: 10-Year Nationwide Prospective Cohort Study

The Relationship Between Sleep Disorders and Combination of Diabetes and Sarcopenia in Adults Aged 45 Years or Older: 10-Year Nationwide Prospective Cohort Study

In addition to psychological [5], environmental [6], lifestyle [7] factors, chronic diseases, such as diabetes [8] and sarcopenia [9] are found to be closely related to sleep disorders. According to the International Diabetes Federation report, a total of 537 million adults worldwide had diabetes in 2021, which is expected to increase by 46% to 783 million by 2045 [10].

Shugang Li, Yimi Wang, Linzhi Li, Hao Wu

JMIR Aging 2025;8:e66372

Estimating the Risk of Lower Extremity Complications in Adults Newly Diagnosed With Diabetic Polyneuropathy: Retrospective Cohort Study

Estimating the Risk of Lower Extremity Complications in Adults Newly Diagnosed With Diabetic Polyneuropathy: Retrospective Cohort Study

Up to 50% of the more than 38 million Americans who have diabetes experience some peripheral nerve damage, known as diabetic polyneuropathy [1,2]. Distal symmetric polyneuropathy, the most common type of diabetic polyneuropathy, is frequently characterized as pain, tingling, and numbness that starts in the extremities. Motor and autonomic involvement, also seen in those with diabetic polyneuropathy, can lead to foot deformity.

Alyce S Adams, Catherine Lee, Gabriel Escobar, Elizabeth A Bayliss, Brian Callaghan, Michael Horberg, Julie A Schmittdiel, Connie Trinacty, Lisa K Gilliam, Eileen Kim, Nima S Hejazi, Lin Ma, Romain Neugebauer

JMIR Diabetes 2025;10:e60141

Metabolic Flexibility to Predict Lifestyle Interventions Outcomes (MEPHISTO): Protocol for Predictive Validation Study and Randomized Controlled Trial

Metabolic Flexibility to Predict Lifestyle Interventions Outcomes (MEPHISTO): Protocol for Predictive Validation Study and Randomized Controlled Trial

Obesity has reached pandemic proportions and is a major risk factor for type 2 diabetes (T2 D), cardiovascular disease, and other metabolic disorders. Prevention progression to T2 D in individuals with obesity through effective lifestyle interventions is a public health priority Substantial and sustained weight loss achieved through lifestyle modifications is a key strategy to reduce the risk of T2 D and improve metabolic health [1,2].

Monika Ludlova, Kateřina Koudelková, Jitka Pallova, Barbora Koudelkova, Michaela Siklova, Monika Cahova, Tomas Vetrovsky, Michal Steffl, Jan Gojda

JMIR Res Protoc 2025;14:e67570

The Effectiveness of a Custom AI Chatbot for Type 2 Diabetes Mellitus Health Literacy: Development and Evaluation Study

The Effectiveness of a Custom AI Chatbot for Type 2 Diabetes Mellitus Health Literacy: Development and Evaluation Study

Diabetes is a highly prevalent chronic disease, with an estimated 537 million people worldwide living with diabetes [1]. Type 2 diabetes mellitus (T2 DM) accounts for approximately 90% of this number. Diabetes is associated with a number of serious complications and is the most common cause of kidney failure requiring dialysis, lower limb amputation, and blindness in working-age adults.

Anthony Kelly, Eoin Noctor, Laura Ryan, Pepijn van de Ven

J Med Internet Res 2025;27:e70131