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Exploratory Impact of iCARE Nigeria, a Combined mHealth and Peer Navigation Intervention, on Depressive Symptoms and Substance Use Among Youth Living With HIV in Nigeria: Single-Arm Trial

Exploratory Impact of iCARE Nigeria, a Combined mHealth and Peer Navigation Intervention, on Depressive Symptoms and Substance Use Among Youth Living With HIV in Nigeria: Single-Arm Trial

Studies conducted in sub-Saharan Africa have reported prevalence rates of depression or probable depression among youth living with HIV ranging from 4.4% to 30.2% [1,8-12] compared to 5.8% to 20% among seronegative youth [11,12]. Substance use has also been found to co-exist with mental health problems in youth living with HIV [13], although this relationship is understudied among youth living with HIV in sub-Saharan Africa.

Olusegun Ayomikun Ogunmola, Rita Frinue Tamambang, Kehinde Kuti, Lisa M Kuhns, Olutosin Awolude, Adedotun Adetunji, Bibilola Oladeji, Oladayo Olaleye, Adeola Mary Oyerinde, Robert Garofalo, Babafemi Taiwo, Olayinka Olusola Omigbodun

JMIR Form Res 2025;9:e71141

Effect of a Family-Centered Empowerment Model–Based Intervention on the Caregiving Capacity and Preparedness of Caregivers of Children With Malignant Neoplasms: Protocol for a Quasi-Experimental Study

Effect of a Family-Centered Empowerment Model–Based Intervention on the Caregiving Capacity and Preparedness of Caregivers of Children With Malignant Neoplasms: Protocol for a Quasi-Experimental Study

Additionally, the study aims to examine the effects of the empowerment intervention on caregivers’ self-efficacy as well as their levels of depression, anxiety, and stress. This study has the following research hypotheses: Statistically significant differences in caregiver preparedness and caregiving capacity will occur after the FCEM intervention program.

Xiaowan Li, Yanhua Yang, Qiurong Chen, JingJing Ma, Feng Lu, Xiaoli Luo

JMIR Res Protoc 2025;14:e73304

Generative AI–Powered Mental Wellness Chatbot for College Student Mental Wellness: Open Trial

Generative AI–Powered Mental Wellness Chatbot for College Student Mental Wellness: Open Trial

Rates of depression, anxiety, and suicidal ideation have surged among college students since the COVID-19 pandemic [1,2]. From 2013 to 2021, the past-year prevalence rate of depression, anxiety, and suicidal ideation has increased by 134.6%, 109.5%, and 64%, respectively, among college students [3]. More than ever before, college counseling centers are unable to meet the increasing mental health needs of their students [4,5].

Jazmin A Reyes-Portillo, Amy So, Kelsey McAlister, Christine Nicodemus, Ashleigh Golden, Colleen Jacobson, Jennifer Huberty

JMIR Form Res 2025;9:e71923

Costs and Outcomes of a Therapist-Guided Internet-Delivered Cognitive Behavioral Therapy: Multicenter Observational Study

Costs and Outcomes of a Therapist-Guided Internet-Delivered Cognitive Behavioral Therapy: Multicenter Observational Study

The following questionnaires were included in the analysis: The 9-item Patient Health Questionnaire (PHQ-9) [42]: The PHQ-9 is a 9-item instrument that measures depression severity on a scale of 0 (“not at all”) to 3 (“nearly every day”) based on the major depression criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Total scores range from 0 to 27, with higher scores indicating more severe depression.

Zareen Abbas Khan, Jørn Heggelund, Stian Lydersen, Kristian Kidholm, Henrik Pedersen, Imre Janszky, Tine Nordgreen, Vidar Halsteinli

J Med Internet Res 2025;27:e73067

Online Peer Support for Long-Term Conditions: Protocol for a Feasibility Randomized Controlled Trial

Online Peer Support for Long-Term Conditions: Protocol for a Feasibility Randomized Controlled Trial

Other studies on specific conditions such as cancer [25] have documented small to moderate reductions in depression, providing early evidence for the benefits of online peer support. Typically, online peer support communities are condition specific, overlooking the opportunity for people living with any long-term condition to reciprocate support based on their shared experience of living with a long-term condition.

Grace Lavelle, Hannah Grace Jones, Ewan Carr, Elly Aylwin-Foster, Vanessa Lawrence, Alan Simpson, Matthew Hotopf

JMIR Res Protoc 2025;14:e71513

Revisiting the Semantic Severity of Anxiety and Depression: Computational Linguistic Study of Normalization and Pathologization

Revisiting the Semantic Severity of Anxiety and Depression: Computational Linguistic Study of Normalization and Pathologization

Building on these findings, Xiao et al [14] analyzed the severity of anxiety and depression in academic abstracts and a diverse collection of American texts, expecting a similar decrease in documenting vertical concept creep. However, the severity increased for both terms and across both text collections, indicating that anxiety and depression are becoming more pathologized rather than normalized.

Vojtech Pisl, Ana-Maria Bucur, Ioana R Podina

J Med Internet Res 2025;27:e73950

Development of a Cocreated Decision Aid for Patients With Depression—Combining Data-Driven Prediction With Patients’ and Clinicians’ Needs and Perspectives: Mixed Methods Study

Development of a Cocreated Decision Aid for Patients With Depression—Combining Data-Driven Prediction With Patients’ and Clinicians’ Needs and Perspectives: Mixed Methods Study

The proposed “Instrument for Shared Decision-Making in Depression (I-SHARED)” CDS tool aims to provide patients and clinicians with (1) thorough, systematic information regarding symptoms, medical history, contextual factors, and potentially worthwhile treatment strategies in a digital report (patient summary) and (2) objective information regarding treatment options to guide depression treatment decisions.

Kaying Kan, Frederike Jörg, Klaas J Wardenaar, Frank J Blaauw, Maarten F Brilman, Ellen Visser, Dennis Raven, Dwayne Meijnckens, Erik Buskens, Danielle C Cath, Bennard Doornbos, Robert A Schoevers, Talitha L Feenstra

J Particip Med 2025;17:e67170

Breath-Focused Mindfulness and Compassion Training in Parent-Child Dyads: Pilot Intervention Study

Breath-Focused Mindfulness and Compassion Training in Parent-Child Dyads: Pilot Intervention Study

The Centers for Disease Control and Prevention estimates a 5% prevalence of depression in US children [1]. Depression in children is comorbid with anxiety and attention deficit [2-5] and may be associated with poor academic performance and school dropout, foretelling poor overall quality of life for these children [6,7]. In serious cases, children with depression can be susceptible to the grave risk of suicide [8].

Satish Jaiswal, Jason Nan, Seth Dizon, Jessica O Young, Suzanna R Purpura, James K Manchanda, Dhakshin Ramanathan, Dennis J Kuo, Jyoti Mishra

JMIR Form Res 2025;9:e69607

The Impact of an Adaptive mHealth Intervention on Improving Patient-Provider Health Care Communication: Secondary Analysis of the DIAMANTE Trial

The Impact of an Adaptive mHealth Intervention on Improving Patient-Provider Health Care Communication: Secondary Analysis of the DIAMANTE Trial

Treatment and care for depression and diabetes, two highly prevalent and often co-occurring conditions [1,2], are often siloed. Individuals with diabetes have an increased risk of developing comorbid depression compared to individuals without diabetes [3].

Lynn Leng, Marvyn R Arévalo Avalos, Adrian Aguilera, Courtney R Lyles

JMIR Mhealth Uhealth 2025;13:e64296

Exploring the Impact of Online Mental Health Resources During the COVID-19 Pandemic on Lesbian, Gay, Bisexual, Transgender, Queer, and Questioning Adults Compared to Heterosexual Adults: Pretest-Posttest Survey Analyses

Exploring the Impact of Online Mental Health Resources During the COVID-19 Pandemic on Lesbian, Gay, Bisexual, Transgender, Queer, and Questioning Adults Compared to Heterosexual Adults: Pretest-Posttest Survey Analyses

Previous analyses on the sample of all respondents found significant levels of COVID-19 stressors, depression, and anxiety for adults (both English and Spanish speaking), and greater use of the website was associated with a reduction in depression for the overall sample [43]. However, the previous analyses and reports did not present findings on LGBTQ+ participants separately or in relation to non-LGBTQ+ peers.

Natalia Ramos, Skylar Jones, Lily Zhang, Miriam Nuño, Benita Ramsey, Dannie Ceseña, Alyssa Mireles, Kenneth Wells

JMIR Form Res 2025;9:e67082