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Virtual Reality for the Prevention and Cessation of Nicotine Vaping in Youths: Protocol for a Randomized Controlled Trial

Virtual Reality for the Prevention and Cessation of Nicotine Vaping in Youths: Protocol for a Randomized Controlled Trial

E-cigarette use is associated with a variety of mental health issues, including depression, internalizing problems, perceived stress, and suicidality [4-6]. Moreover, the percentage of high school students experiencing persistent feelings of sadness or hopelessness (for at least 2 consecutive weeks) increased from 28% in 2011 to 42% in 2021 [7,8].

Belinda Borrelli, Daniel Weinstein, Romano Endrighi, Nikki Ling, Kathleen Koval, Lisa M Quintiliani, Kaitlyn Konieczny

JMIR Res Protoc 2025;14:e71961

Postpartum Depression and Maternal-Infant Bonding Experiences in Social Media Videos: Qualitative Content Analysis

Postpartum Depression and Maternal-Infant Bonding Experiences in Social Media Videos: Qualitative Content Analysis

Yet, recent studies on the operationalization of the MIB find the construct, content, and structural validity of MIB measures, including measures validated in women with postpartum depression, to be insufficient [10,11]. A lack of diverse samples in measurement development may contribute to this issue [11]. Most qualitative studies focus on maternal depression more broadly rather than the MIB in mothers with depression.

Kunmi Sobowale, Jamie Sarah Castleman, Sophia Yingruo Zhao

JMIR Infodemiology 2025;5:e59125

Peer Relationships Are a Direct Cause of the Adolescent Mental Health Crisis: Interpretable Machine Learning Analysis of 2 Large Cohort Studies

Peer Relationships Are a Direct Cause of the Adolescent Mental Health Crisis: Interpretable Machine Learning Analysis of 2 Large Cohort Studies

In the United States, after a years-long decline, rising depression among adolescents has been reported since about 2010 [6], accompanied by an increase in suicide rates in this age group [7]. While prevalence rates for externalizing mental health problems among children and adolescents in Germany were declining before the COVID-19 pandemic, emotional problems also increased here between 2003‐2006 and 2014‐2017, especially among girls [8].

Heiner Stuke, Robert Schlack, Michael Erhart, Anne Kaman, Ulrike Ravens-Sieberer, Christopher Irrgang

JMIR Public Health Surveill 2025;11:e60125

Digital Integrated Interventions for Comorbid Depression and Substance Use Disorder: Narrative Review and Content Analysis

Digital Integrated Interventions for Comorbid Depression and Substance Use Disorder: Narrative Review and Content Analysis

Early sessions include clinical assessment, diagnostic feedback, case formulation covering the development and maintenance of the conditions, psychoeducation about the relationship between depression and substance use, and MI to elicit behavior change planning.

Geneva K Jonathan, Qiuzuo Guo, Heyli Arcese, A Eden Evins, Sabine Wilhelm

JMIR Ment Health 2025;12:e67670

Addressing the Stigma of Mental Illness in Black Families and Communities in Ontario, Canada: Protocol for a Mixed Methods Study

Addressing the Stigma of Mental Illness in Black Families and Communities in Ontario, Canada: Protocol for a Mixed Methods Study

An online survey will be used to assess participants’ mental health status using the Depression, Anxiety, and Stress Scale-21 Items (DASS-21) [60], stigma of mental illness using the Community Attitudes toward the Mentally Ill (CAMI) scale [61], discrimination using the Everyday Discrimination Scale (EDS) [62], and mental health literacy using the Mental Health Literacy Questionnaire-Short Version for Adults (MHLq-SVa) [63].

Joseph Adu, Josephine P H Wong, Priscilla Boakye, Sebastian Gyamfi, Egbe B Etowa, Mark Fordjour Owusu

JMIR Res Protoc 2025;14:e66851

Effectiveness and Implementation Outcomes of an mHealth App Aimed at Promoting Physical Activity and Improving Psychological Distress in the Workplace Setting: Cluster-Level Nonrandomized Controlled Trial

Effectiveness and Implementation Outcomes of an mHealth App Aimed at Promoting Physical Activity and Improving Psychological Distress in the Workplace Setting: Cluster-Level Nonrandomized Controlled Trial

In 2019, an estimated 301 million working-age adults experienced anxiety, while approximately 280 million had depression [1]. Furthermore, many workers report subclinical symptoms such as psychological distress [2-4]. These mental health concerns lead to increased absenteeism, deteriorating quality of life, and overall well-being [5]. The global economic burden of mental health conditions is estimated at approximately US $1 trillion annually, primarily due to productivity losses [1,6,7].

Kazuhiro Watanabe, Mitsuhiro Sato, Shoichi Okusa, Akizumi Tsutsumi

JMIR Mhealth Uhealth 2025;13:e70473

Impact of a Digital Decision Aid When Choosing Between Face-to-Face and Guided Internet-Based Psychological Interventions for Depression Among Chinese-Speaking Participants in Hong Kong: Randomized Controlled Trial

Impact of a Digital Decision Aid When Choosing Between Face-to-Face and Guided Internet-Based Psychological Interventions for Depression Among Chinese-Speaking Participants in Hong Kong: Randomized Controlled Trial

Depression is prevalent and a leading cause of disability, mortality, loss of productivity, and health care expenditure [1]. Psychological interventions not only are effective for the treatment of depression [2] but are also considered a first-line treatment for major depression [3]. Psychological interventions are also the preferred treatment method for most people with depression [4].

Larry Auyeung, Winnie WS Mak, Ella Zoe Tsang, Philo Liu Yang

J Med Internet Res 2025;27:e54727

Cognitive Behavioral Immersion for Depression: Protocol for a Three-Arm Randomized Controlled Trial of Peer-Based Coaching in the Metaverse

Cognitive Behavioral Immersion for Depression: Protocol for a Three-Arm Randomized Controlled Trial of Peer-Based Coaching in the Metaverse

Approximately 280 million people worldwide are experiencing depression [1], and nearly half of those people also experience comorbid anxiety [2]. Symptoms of either disorder can cause substantial distress and impair functioning across all domains of life. Worse yet, the prevalence and severity of these disorders are growing [3].

Noah Robinson, Francisco N Ramos, Steven D Hollon, Gloria T Han, Iony D Ezawa

JMIR Res Protoc 2025;14:e65970

Interventions to Foster Mental Health and Reintegration in Individuals Who Are Unemployed: Systematic Review

Interventions to Foster Mental Health and Reintegration in Individuals Who Are Unemployed: Systematic Review

Numerous studies have shown that the prevalence rates of clinically relevant mental health problems, such as symptoms of depression, anxiety disorders, and psychosomatic illnesses, are increased in the unemployed population compared with the employed population [6,7]. While the point prevalence of depression in the general population ranges between 6.38% [8] and 12.9% [9], an aggregate increased prevalence of 24% persists for individuals who are unemployed [7].

Sophia Helen Adam, Florian Junne, Svenja Schlachter, Miriam Mehler, Harald Gündel, Nicolas Rüsch, Jörn von Wietersheim, Katrin Elisabeth Giel, Stephan Zipfel, Rebecca Erschens

JMIR Public Health Surveill 2025;11:e65698

Virtual Versus In-Person Intensive Outpatient Treatment for Eating Disorders During the COVID-19 Pandemic in United States–Based Treatment Facilities: Naturalistic Study

Virtual Versus In-Person Intensive Outpatient Treatment for Eating Disorders During the COVID-19 Pandemic in United States–Based Treatment Facilities: Naturalistic Study

The COVID-19 pandemic exacerbated almost every mental health disorder, including anxiety, depression [1], and eating disorders (EDs) [2]. EDs are associated with high rates of morbidity and mortality [3], and poor quality of life [4]. Schlegl et al [2] found that while 70% of patients with EDs reported an increase in symptoms after the onset of COVID-19, access to in-person therapy decreased by 37% at the same time. Only 26% of patients surveyed used videoconferencing for therapy.

Dan V Blalock, Philip S Mehler, Deborah M Michel, Alan Duffy, Daniel Le Grange, Anne M O'Melia, Renee D Rienecke

J Med Internet Res 2025;27:e66465