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Developing a Core Outcome Set for Pediatric and Adult Acute and Chronic Pain Extended Reality Trials: Delphi Consensus-Building Process

Developing a Core Outcome Set for Pediatric and Adult Acute and Chronic Pain Extended Reality Trials: Delphi Consensus-Building Process

Acute pain (eg, injury, procedural pain, and medical treatments), recurrent pain (eg, headaches), and chronic pain (eg, musculoskeletal and complex regional pain syndrome) are common among adults and children and can have negative short- and long-term physical and mental health consequences. Poorly treated acute pain can transition to chronic pain, which affects 1 in 5 people [1-3] and has negative impacts on all aspects of quality of life [4], as well as high economic costs to families and society [5,6].

Courtney W Hess, Deirdre E Logan, Brittany N Rosenbloom, Giulia Mesaroli, Laura E Simons, Carley Ouellette, Cynthia Nguyen, Fahad Alam, Jennifer N Stinson

J Med Internet Res 2025;27:e58947

Digital Health Literacy in Adults With Low Reading and Writing Skills Living in Germany: Mixed Methods Study

Digital Health Literacy in Adults With Low Reading and Writing Skills Living in Germany: Mixed Methods Study

In addition, adults with low reading and writing skills are less likely to write emails or search for health-related information on the internet compared with adults with sufficient reading and writing skills [14].

Saskia Muellmann, Rebekka Wiersing, Hajo Zeeb, Tilman Brand

JMIR Hum Factors 2025;12:e65345

Relationship Between Within-Session Digital Motor Skill Acquisition and Alzheimer Disease Risk Factors Among the MindCrowd Cohort: Cross-Sectional Descriptive Study

Relationship Between Within-Session Digital Motor Skill Acquisition and Alzheimer Disease Risk Factors Among the MindCrowd Cohort: Cross-Sectional Descriptive Study

Since the number of cases of Alzheimer disease (AD) is expected to double in the next 2 decades [1], there is an urgent need for widespread screening of older adults for their individual AD risk profile, which has implications for clinical care and research. Current options, such as positron emission tomography for measuring tau and beta amyloid pathology, tend to be expensive and invasive and require advanced imaging facilities [2].

Andrew Hooyman, Matt J Huentelman, Matt De Both, Lee Ryan, Kevin Duff, Sydney Y Schaefer

JMIR Aging 2025;8:e67298

Primary Tumors of the Brain and Central Nervous System in Adults and Children in Sub-Saharan Africa: Protocol for a Scoping Review

Primary Tumors of the Brain and Central Nervous System in Adults and Children in Sub-Saharan Africa: Protocol for a Scoping Review

Late detection of cancers is common, with later reporting and higher reported case fatality rates among adults and children [4]. Furthermore, the SSA medical workforce in oncology, neurology, and neurosurgery is severely undercapacitated, further impeding the effective management of brain and CNS tumors. Although less common than other neoplasms, CNS tumors rank comparatively high as a cause of death due to their high case fatality rates.

Alhasan Ahmed Badeea Al-Fikri, Mesk Alhammadi, Chiedozie Arum, Mahima Kaur, Kayla Del Biondo, Ibrahim Bani, Victor Mudenda, Sten H Vermund

JMIR Res Protoc 2025;14:e66978

Exploring Climate Change’s Impact on the Cardiopulmonary Health of Adults Living in the Canton of Valais, Switzerland: Protocol for a Development and Usability Pilot Study

Exploring Climate Change’s Impact on the Cardiopulmonary Health of Adults Living in the Canton of Valais, Switzerland: Protocol for a Development and Usability Pilot Study

In recent years, several studies have been conducted on the various components of the relationship between health and climate change in Switzerland, particularly via the Swiss Study on Air Pollution and Lung and Health Diseases in Adults cohort [6]. A review of 22 studies by Cicci et al [7] highlighted positive associations between high temperatures and ischemic heart disease, acute myocardial infarction, the risk of congestive heart failure, and the number of emergency department (ED) consultations.

Omar Portela Dos Santos, Paulo Jorge Pereira Alves, Henk Verloo

JMIR Res Protoc 2025;14:e67128

Multilevel Intervention to Increase Patient Portal Use in Adults With Type 2 Diabetes Who Access Health Care at Community Health Centers: Single Arm, Pre-Post Pilot Study

Multilevel Intervention to Increase Patient Portal Use in Adults With Type 2 Diabetes Who Access Health Care at Community Health Centers: Single Arm, Pre-Post Pilot Study

In adults with diabetes, greater portal use of secure messaging with providers led to improved glycemic control (measured based on hemoglobin A1c [Hb A1c] levels) compared to nonusers [9-12]. Other trials have demonstrated significant reductions in Hb A1c through diabetes self-management education or support (DSMS) via the portal [13-15]. Thus, fostering communication with providers and diabetes self-management support are promising features of portals for adults with diabetes.

Robin Whittemore, Sangchoon Jeon, Samuel Akyirem, Helen N C Chen, Joanna Lipson, Maritza Minchala, Julie Wagner

JMIR Form Res 2025;9:e67293

Acceptability and Effectiveness of a Fully Web-Based Nutrition and Exercise Program for Individuals With Chronic Disease During COVID-19: Randomized Controlled Trial

Acceptability and Effectiveness of a Fully Web-Based Nutrition and Exercise Program for Individuals With Chronic Disease During COVID-19: Randomized Controlled Trial

Inclusion criteria included adults (aged 18 years and older) with an internet-connected device in their home and the ability to read, write, and speak English. Individuals were eligible if they had cancer (completed an initial course of chemotherapy or radiotherapy but could be on maintenance therapy); had undergone a lung or liver transplant; or had chronic lung disease. All had to graduate from an exercise rehabilitation program before the COVID-19 public health restrictions.

Puneeta Tandon, Kathleen P Ismond, Graeme Purdy, Christofer Cruz, Evelyn Etruw, Kirsten Suderman, Ashley Hyde, Michael Stickland, John C Spence, Dale C Lien, Rahima Bhanji, Carla M Prado, Antonio Miguel-Cruz, Anil A Joy, Maryna Yaskina, Margaret L McNeely

J Med Internet Res 2025;27:e57537

Comparison of Outcomes Between Staged and Same-Day Circumferential Spinal Fusion for Adult Spinal Deformity: Systematic Review and Meta-Analysis

Comparison of Outcomes Between Staged and Same-Day Circumferential Spinal Fusion for Adult Spinal Deformity: Systematic Review and Meta-Analysis

Population: Adults with ASD Intervention: Staged CF surgery Comparison: Same-day CF surgery Outcomes: Perioperative outcomes (estimated blood loss [EBL], operative time, and length of hospital stay), adverse events, infection rates, and hospital readmissions or reoperations Studies that do not differ in surgical timing (staged vs same day), nonhuman or adolescent patient populations, reviews, conference abstracts, single-case studies, or technical notes were excluded from the analysis.

Mert Marcel Dagli, Ryan William Turlip, Felix C Oettl, Mohamed Emara, Jaskeerat Gujral, Daksh Chauhan, Hasan S Ahmad, Gabrielle Santangelo, Connor Wathen, Yohannes Ghenbot, John D Arena, Joshua L Golubovsky, Ben J Gu, John H Shin, Jang Won Yoon, Ali K Ozturk, William C Welch

Interact J Med Res 2025;14:e67290

Usage Trends and Data Sharing Practices of Healthcare Wearable Devices Among US Adults: Cross-Sectional Study

Usage Trends and Data Sharing Practices of Healthcare Wearable Devices Among US Adults: Cross-Sectional Study

This study aims to answer the following questions: How has wearable device usage among US adults changed since 2019, and what factors are associated with wearable use in the postpandemic era? What are the key sociodemographic, health, and technological factors that influence US adults’ willingness to share health data from wearable devices with health care providers, and with their family and friends?

Ranganathan Chandrasekaran, Muhammed Sadiq T, Evangelos Moustakas

J Med Internet Res 2025;27:e63879

Virtual Reality Interventions and Chronic Pain: Scoping Review

Virtual Reality Interventions and Chronic Pain: Scoping Review

Chronic pain affects 50 million US adults [1], and treatments have limited long-term efficacy, significant side effects, or limited accessibility [2-5]. As a result of the continuing opioid overdose crisis, numerous clinical and research guidelines have recommended further study of nonpharmacological options [6-8]. Virtual reality (VR) treatments have the potential to immerse participants within a virtual environment to confer health benefits to users.

Michael E Ding, Hajar Traiba, Hector R Perez

J Med Internet Res 2025;27:e59922