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Effectiveness and Cost-Effectiveness of Blended Cognitive Behavioral Therapy in Clinically Depressed Adolescents: Protocol for a Pragmatic Quasi-Experimental Controlled Trial

Effectiveness and Cost-Effectiveness of Blended Cognitive Behavioral Therapy in Clinically Depressed Adolescents: Protocol for a Pragmatic Quasi-Experimental Controlled Trial

They have a substantial effect on well-being, a high burden of disease, and a high risk of recurrence and chronicity [1,2]. At the age of 18 years, more than 15% of adolescents have suffered from a major depressive disorder [3]. Depression shows high comorbidity with other mental health diagnoses and increased social problems, decreased academic performance, increased school dropouts, more substance abuse, and an increased risk of suicide attempts and suicide [1,2,4].

Sanne P A Rasing, Yvonne A J Stikkelbroek, Heleen Riper, Maja Dekovic, Maaike H Nauta, Carmen D Dirksen, Daan H M Creemers, Denise H M Bodden

JMIR Res Protoc 2019;8(10):e13434