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Impact of Conversational and Animation Features of a Mental Health App Virtual Agent on Depressive Symptoms and User Experience Among College Students: Randomized Controlled Trial

Impact of Conversational and Animation Features of a Mental Health App Virtual Agent on Depressive Symptoms and User Experience Among College Students: Randomized Controlled Trial

Cognitive behavioral therapy (CBT)-based mental health apps represent a viable option to improve access to mental health resources [3]. A form of CBT, brief cognitive behavioral therapy (b CBT) has been suggested for depressive individuals as a means of maintaining the user’s attention while not requiring large amounts of the user’s time or energy.

Stephanie Six, Elizabeth Schlesener, Victoria Hill, Sabarish V Babu, Kaileigh Byrne

JMIR Ment Health 2025;12:e67381

Adapting Cognitive Behavioral Therapy for Adolescents in Iraq via Mobile Apps: Qualitative Study of Usability and Outcomes

Adapting Cognitive Behavioral Therapy for Adolescents in Iraq via Mobile Apps: Qualitative Study of Usability and Outcomes

Among the various therapeutic approaches, cognitive behavioral therapy (CBT) has proven to be particularly effective in addressing common adolescent mental health issues like anxiety and depression [20-24]. CBT focuses on helping individuals identify and modify negative thought patterns and behaviors, making it well suited for delivery via mobile platforms that offer interactive and self-guided modules [25-28].

Radhwan Hussein Ibrahim, Marghoob Hussein Yaas, Mariwan Qadir Hamarash, Salwa Hazim Al-Mukhtar, Mohammed Faris Abdulghani, Osama Al Mushhadany

JMIR Pediatr Parent 2025;8:e67137

Psychological eHealth Interventions for Patients With Cardiovascular Diseases: Systematic Review and Meta-Analysis

Psychological eHealth Interventions for Patients With Cardiovascular Diseases: Systematic Review and Meta-Analysis

For ICBT interventions, most incorporated core CBT techniques like behavioral activation, worry management, and problem-solving. Specific areas such as psychoeducation [33,35] or the psychosocial aspects of implantable cardioverter defibrillators [38] were the focus of some interventions. Additionally, certain programs integrated additional therapeutic methods, including interpersonal therapy [37] or mindfulness [24].

Jing Jing Su, Rose Lin, Ladislav Batalik, Arkers Kwan Ching Wong, Sherry L Grace

J Med Internet Res 2025;27:e57368

Personalized Physician-Assisted Sleep Advice for Shift Workers: Algorithm Development and Validation Study

Personalized Physician-Assisted Sleep Advice for Shift Workers: Algorithm Development and Validation Study

CBT-i Coach is another phone app developed as a supplemental tool for face-to-face CBTI in which users can receive sleep education, customize sleep hygiene advice and relaxation activities, and practice personalized sleep restrictions [27]. In a pilot study, the app did not impair CBTI effectiveness and potentially improved patient adherence [28].

Yufei Shen, Alicia Choto Olivier, Han Yu, Asami Ito-Masui, Ryota Sakamoto, Motomu Shimaoka, Akane Sano

JMIR Form Res 2025;9:e65000

Development of a Voice-Activated Virtual Assistant to Improve Insomnia Among Young Adult Cancer Survivors: Mixed Methods Feasibility and Acceptability Study

Development of a Voice-Activated Virtual Assistant to Improve Insomnia Among Young Adult Cancer Survivors: Mixed Methods Feasibility and Acceptability Study

Cognitive behavioral therapy for insomnia (CBT-I) is the gold standard intervention recommended by the National Comprehensive Cancer Network (NCCN) to address insomnia in cancer survivor populations [18-20]. Previous studies have demonstrated the effectiveness of CBT-I among YACSs [21,22]. However, widespread accessibility to CBT-I remains challenging due to an insufficient number of trained providers, a lack of insurance coverage, and even language barriers [23,24].

Hunter Groninger, Hannah Arem, Lylian Ayangma, Lisa Gong, Eric Zhou, Daniel Greenberg

JMIR Form Res 2025;9:e64869

Generative AI–Enabled Therapy Support Tool for Improved Clinical Outcomes and Patient Engagement in Group Therapy: Real-World Observational Study

Generative AI–Enabled Therapy Support Tool for Improved Clinical Outcomes and Patient Engagement in Group Therapy: Real-World Observational Study

Cognitive behavioral therapy (CBT) has been shown to be a highly effective treatment for depression and anxiety disorders [4-6] and is the first line of treatment for these conditions in many therapy guidelines worldwide [7,8]. Nonetheless, CBT does not benefit everyone. In fact, a recent meta-analysis of 409 trials reported that 58% of patients do not respond to treatment [5]. Several reasons for unsuccessful therapy have been identified.

Johanna Habicht, Larisa-Maria Dina, Jessica McFadyen, Mona Stylianou, Ross Harper, Tobias U Hauser, Max Rollwage

J Med Internet Res 2025;27:e60435

A Web-Based Resource Informed by Cognitive Behavioral Therapy and Positive Psychology to Address Stress, Negative Affect, and Problematic Alcohol Use: A Usability and Descriptive Study

A Web-Based Resource Informed by Cognitive Behavioral Therapy and Positive Psychology to Address Stress, Negative Affect, and Problematic Alcohol Use: A Usability and Descriptive Study

Therefore, cognitive behavioral therapy (CBT) can be personalized with PPI components that target motivational and emotional factors. With a focus on increasing positive emotions, behaviors, and cognitions, PPI approaches align well with CBT principles and both can be leveraged with the objective to reduce stress with negative affect aimed at mitigating cravings for alcohol to self-medicate.

Ingrid Serck-Hanssen, Marit Solheim-Witt, Justin J Anker, Dawn E Sugarman

JMIR Form Res 2025;9:e63819

The Effects of Digital eHealth Versus Onsite 2-Day Group-Based Education in 255 Patients With Irritable Bowel Syndrome: Cohort Study

The Effects of Digital eHealth Versus Onsite 2-Day Group-Based Education in 255 Patients With Irritable Bowel Syndrome: Cohort Study

Approaches may include physical therapy, cognitive behavioral therapy (CBT), hypnotherapy, mindfulness and exposure therapy, and comprehensive dietary guidance by registered dietitians such as the low FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) diet. However, access to these treatment options is often limited due to lack of trained professionals, travel distances, and cost. Thus, more accessible treatment options are warranted.

Birgitte Berentsen, Camilla Thuen, Eline Margrete Randulff Hillestad, Elisabeth Kjelsvik Steinsvik, Trygve Hausken, Jan Gunnar Hatlebakk

JMIR Hum Factors 2025;12:e43618

Effectiveness of Cognitive Behavioral Therapy Provided Through a Web Application for Subthreshold Depression, Subthreshold Insomnia, and Subthreshold Panic: Open-Labeled 6-Arm Randomized Clinical Trial Pilot Study

Effectiveness of Cognitive Behavioral Therapy Provided Through a Web Application for Subthreshold Depression, Subthreshold Insomnia, and Subthreshold Panic: Open-Labeled 6-Arm Randomized Clinical Trial Pilot Study

With limited reports, cognitive behavioral therapy (CBT) has been shown to be effective for subthreshold symptoms. CBT, which is a type of psychological therapy, improves symptoms by understanding patterns of maladaptive thinking and behavior and correcting the vicious cycle that perpetuates symptoms. It has been shown to be effective in improving diagnosed depression, anxiety, and insomnia [12-14].

Kayoko Taguchi, Mirai Miyoshi, Yoichi Seki, Shiori Baba, Eiji Shimizu

JMIR Form Res 2025;9:e63139