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Brain Mechanisms of Virtual Reality Breathing Versus Traditional Mindful Breathing in Pain Modulation: Observational Functional Near-infrared Spectroscopy Study

Within each trial of the 20 trials, the thermode temperature controlled by the controlling device increased from a baseline of 30 °C (86 °F) to a maximum temperature of 50 °C (122 °F), with an increase rate of 1 °C per second. We instructed participants to click the button on the mouse at the first detection of pain, as it stopped the temperature from increasing. The thermode temperature then returned to its baseline and gave the subject a 10-second rest period before the next thermal trial.

Xiao-Su Hu, Katherine Beard, Mary Catherine Sherbel, Thiago D Nascimento, Sean Petty, Eddie Pantzlaff, David Schwitzer, Niko Kaciroti, Eric Maslowski, Lawrence M Ashman, Stephen E Feinberg, Alexandre F DaSilva