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Machine Learning–Based Prediction of Substance Use in Adolescents in Three Independent Worldwide Cohorts: Algorithm Development and Validation Study

Machine Learning–Based Prediction of Substance Use in Adolescents in Three Independent Worldwide Cohorts: Algorithm Development and Validation Study

Proposed by Lundberg and Lee, SHAP offers a unified framework for explaining the output of any ML model [25]. This technique visualizes the contribution of each feature to the model’s prediction for a specific instance, illustrating how each feature shifts the model’s output from the base value. All computations, model training, validation, and evaluation processes were executed using Python (version 3.12.4; Python Software Foundation).

Soeun Kim, Hyejun Kim, Seokjun Kim, Hojae Lee, Ahmed Hammoodi, Yujin Choi, Hyeon Jin Kim, Lee Smith, Min Seo Kim, Guillaume Fond, Laurent Boyer, Sung Wook Baik, Hayeon Lee, Jaeyu Park, Rosie Kwon, Selin Woo, Dong Keon Yon

J Med Internet Res 2025;27:e62805