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Feasibility, Acceptability, and Protective Efficacy of Seasonal Malaria Chemoprevention Implementation in Nampula Province, Mozambique: Protocol for a Hybrid Effectiveness-Implementation Study

Feasibility, Acceptability, and Protective Efficacy of Seasonal Malaria Chemoprevention Implementation in Nampula Province, Mozambique: Protocol for a Hybrid Effectiveness-Implementation Study

The study will be powered to have an 80% chance of detecting a significant reduction in RDT-confirmed malaria incidence at the 5% confidence level using a chi-square test comparing two independent proportions in a cluster randomized design. We are aiming to detect a significant reduction in malaria incidence from 0.2 to 0.12 clinical episodes per child per high-transmission season, corresponding to the SMC round.

Kevin Baker, Pedro Aide, Craig A Bonnington, Christian Rassi, Sol Richardson, Arantxa Roca-Feltrer, Maria Rodrigues, Mercia Sitoe, Ivan Alejandro Pulido Tarquino, Sonia Enosse, Caitlin McGugan, Eva Amelia de Carvalho, Francisco Saute, Alfredo Gabriel Mayor Aparicio, Baltazar Candrinho

JMIR Res Protoc 2022;11(9):e36403

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Article has an altmetric score of 4

Assessment of the Feasibility, Acceptability, and Impact of Implementing Seasonal Malaria Chemoprevention in Nampula Province, Mozambique: Protocol for a Hybrid Effectiveness-Implementation Study

Assessment of the Feasibility, Acceptability, and Impact of Implementing Seasonal Malaria Chemoprevention in Nampula Province, Mozambique: Protocol for a Hybrid Effectiveness-Implementation Study

Exclusion criteria include the presence of a severe, chronic illness and a history of a significant adverse reaction to SP or AQ. Selected children will be treated appropriately and retained during the trial. In the control district, communities bordering the intervention district will be avoided because of potential unintended leakage of SPAQ across the district boundary.

Alexandra Nicholas Wharton-Smith, Kevin Baker, Arantxa Roca-Feltrer, Maria Rodrigues, Sol Richardson, Craig A Bonnington, Christian Rassi, Madeleine Marasciulo, Sonia Enosse, Francisco Saute, Pedro Aide, Eusebio Macete, Baltazar Candrinho

JMIR Res Protoc 2021;10(9):e27855

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Article has an altmetric score of 13