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The Brain and Early Experience Study: Protocol for a Prospective Observational Study
For tests of mediation (encompassing the main effects as mediated by prenatal and postnatal experiences), the sample has power (>0.99) to detect single mediated effects when both the a and b paths are of medium size (R2=0.13). The study has power (>0.89) to detect a mediated effect when both a and b paths are of small to medium size (R2=0.075). However, the power to detect a mediated effect drops to 0.45 when either a or b paths are of small size (R2=0.02), even if the other path is of medium size.
JMIR Res Protoc 2022;11(6):e34854
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