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Primary Prevention of Stroke in Children With Sickle Cell Anemia in Nigeria: Protocol for a Mixed Methods Implementation Study in a Community Hospital

Primary Prevention of Stroke in Children With Sickle Cell Anemia in Nigeria: Protocol for a Mixed Methods Implementation Study in a Community Hospital

Without any intervention for primary stroke prevention, children with SCA have a 10% annual risk of developing a stroke [1]. In sub-Saharan Africa, about 11% of these children will develop a stroke before their 20th birthday [2]. In Nigeria, the country with the highest birth rate of newborns with SCA, over 150,000 births per year, there is a minimum estimate of 10,000 stroke episodes in children with SCA for the birth year cohort (assuming minimum mortality) [3].

Halima Bello-Manga, Lawal Haliru, Kudrat Abdulkareem Ahmed, Abdulkadir Musa Tabari, Bilkisu Usman Farouk, Gloria Yimi Bahago, Aisha Shuaibu Kazaure, Abdulrasheed Sani Muhammad, Samira Abubakar Gwarzo, Ana A Baumann, Michael R DeBaun, Allison A King

JMIR Res Protoc 2022;11(6):e37927

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Engaging Caregivers and Providers of Children With Sickle Cell Anemia in Shared Decision Making for Hydroxyurea: Protocol for a Multicenter Randomized Controlled Trial

Engaging Caregivers and Providers of Children With Sickle Cell Anemia in Shared Decision Making for Hydroxyurea: Protocol for a Multicenter Randomized Controlled Trial

Stakeholders will be coauthors of peer-reviewed publications, and the study results in a format suitable for a nonspecialist audience will be sent to the patients and caregivers.

Anna M Hood, Heather Strong, Cara Nwankwo, Yolanda Johnson, James Peugh, Constance A Mara, Lisa M Shook, William B Brinkman, Francis J Real, Melissa D Klein, Rogelle Hackworth, Sherif M Badawy, Alexis A Thompson, Jean L Raphael, Amber M Yates, Kim Smith-Whitley, Allison A King, Cecelia Calhoun, Susan E Creary, Connie M Piccone, Aimee K Hildenbrand, Steven K Reader, Lynne Neumayr, Emily R Meier, Amy E Sobota, Sohail Rana, Maria Britto, Kay L Saving, Marsha Treadwell, Charles T Quinn, Russell E Ware, Lori E Crosby

JMIR Res Protoc 2021;10(5):e27650

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Electronic Health Record–Embedded Individualized Pain Plans for Emergency Department Treatment of Vaso-occlusive Episodes in Adults With Sickle Cell Disease: Protocol for a Preimplementation and Postimplementation Study

Electronic Health Record–Embedded Individualized Pain Plans for Emergency Department Treatment of Vaso-occlusive Episodes in Adults With Sickle Cell Disease: Protocol for a Preimplementation and Postimplementation Study

The study protocol was also developed based on the Standard Protocol Items for Clinical Trials [29], a guideline for the minimum content of a clinical trial protocol, and the Standards for Reporting Implementation Studies [30], a guideline to improve the reporting of implementation studies. The study uses a preimplementation and postimplementation design in which the IPPs will be embedded in patient EHRs, with both provider and patient having access to view the E-IPPs.

Lingzi Luo, Allison A King, Yvonne Carroll, Ana A Baumann, Donald Brambilla, Christopher R Carpenter, Joseph Colla, Robert W Gibson, Siera Gollan, Greg Hall, Lisa Klesges, Abdullah Kutlar, Matthew Lyon, Cathy L Melvin, Sarah Norell, Martina Mueller, Michael B Potter, Rachel Richesson, Lynne D Richardson, Gery Ryan, Lauren Siewny, Marsha Treadwell, Leslie Zun, Janelle Armstrong-Brown, Lisa Cox, Paula Tanabe

JMIR Res Protoc 2021;10(4):e24818

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