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YAHR are difficult to identify and intervene with in medical clinics because most youth (about 60% of general adolescent population) do not access health care [8-10]. Adolescents typically fail to disclose their sexual behaviors to their families or their physicians, most often because they are never asked about risk [11-13].
JMIR Res Protoc 2019;8(8):e11165
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A set of 3 interrelated studies, known as the Comprehensive Adolescent Research and Engagement Studies (CARES), is being mounted to evaluate strategies to increase youth’s uptake, maintenance, and retention in the HIV Prevention and Treatment Continua [2-4].
Participants are acutely infected YLH, YLH with established HIV infection, and YHR. This paper summarizes the rationale behind these studies, including the recruitment, retention, assessment, and intervention strategies common across them.
JMIR Res Protoc 2019;8(1):e10759
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To further demonstrate the effectiveness of early antiretroviral therapy on infants, a large multicenter phase 3 trial, National Institute of Child Health and Development HIV Prevention Trials Network 040, conducted by our team of investigators revealed that c ART reduced intrapartum HIV transmission by 50% [19] in high-risk HIV-exposed infants whose mothers did not receive c ART during pregnancy.
JMIR Res Protoc 2019;8(1):e10807
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This paper fills in gaps in the literature by describing the EDC system from an ongoing HIV biobehavioral intervention trial, Adolescent Medicine Trials Network “Comprehensive Adolescent Research & Engagement Studies” (ATN CARES), and highlights the benefits and limitations of what current EDC systems can provide. We begin with an overview of EDC system functionality and highlight salient features for behavioral intervention trials.
JMIR Res Protoc 2018;7(12):e10777
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