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Opportunities and Challenges in Using Electronic Health Record Systems to Study Postacute Sequelae of SARS-CoV-2 Infection: Insights From the NIH RECOVER Initiative

Opportunities and Challenges in Using Electronic Health Record Systems to Study Postacute Sequelae of SARS-CoV-2 Infection: Insights From the NIH RECOVER Initiative

For example, Rao et al [28] leveraged PEDSnet’s geographical and clinical breadth to identify risk factors such as age, severity of acute COVID-19 infection, and comorbid conditions. Potential biological variables that are well-defined in EHRs and therefore, more reliably available for application in adjusted analyses include age, sex, BMI, and blood pressure, and, indeed, these variables have been shown to confound the evaluation of causal pathways for long COVID [49-51].

Hannah L Mandel, Shruti N Shah, L Charles Bailey, Thomas Carton, Yu Chen, Shari Esquenazi-Karonika, Melissa Haendel, Mady Hornig, Rainu Kaushal, Carlos R Oliveira, Alice A Perlowski, Emily Pfaff, Suchitra Rao, Hanieh Razzaghi, Elle Seibert, Gelise L Thomas, Mark G Weiner, Lorna E Thorpe, Jasmin Divers, RECOVER EHR Cohort

J Med Internet Res 2025;27:e59217