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Advancing Real-World Evidence Through a Federated Health Data Network (EHDEN): Descriptive Study

Clair Blacketer, Martijn J Schuemie, Maxim Moinat, Erica A Voss, Montse Camprubi, Peter R Rijnbeek, Patrick B Ryan

J Med Internet Res 2025;27:e74119

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Federated Analysis With Differential Privacy in Oncology Research: Longitudinal Observational Study Across Hospital Data Warehouses

Théo Ryffel, Perrine Créquit, Maëlle Baillet, Jason Paumier, Yasmine Marfoq, Olivier Girardot, Thierry Chanet, Ronan Sy, Louise Bayssat, Julien Mazières, Vincent Vuiblet, Julien Ancel, Maxime Dewolf, François Margraff, Camille Bachot, Jacek Chmiel

JMIR Med Inform 2025;13:e59685

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Using Linked Health Service Data in Multimodal Modeling of Kidney Transplant Waitlist Outcomes: Protocol for the Maximizing Organ Donor Utility Systemwide (MODUS) Study

Brenda Maria Rosales, Karan Shah, Nicole De La Mata, Heather Baldwin, James Hedley, Philip Clayton, Melanie Wyld, Patrick Kelly, Kate Wyburn, Rachael Morton, Angela Webster, MODUS Study Group

JMIR Res Protoc 2025;14:e67588

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Gait Disturbances in Older Adults With Cerebral Small Vessel Disease: Mixed Methods Study Using Smartphone Sensors and Video Analysis

Xiaojun Lai, Li-Yan Qiao, Pei-Luen Patrick Rau, Yankuan Liu

JMIR Form Res 2025;9:e58864

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Patient Portal Registrations at a Swiss Tertiary Referral Hospital Over the Course of the COVID-19 Pandemic: Retrospective Data Analysis

Anita D Linke, Amanda Franklin-Ryan, Angela Horn, Patrick E Beeler, Balthasar L Hug

J Med Internet Res 2025;27:e56961

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Evaluating the Effectiveness of a Mobile HIV Prevention App to Increase HIV and Sexually Transmitted Infection Testing and Pre-Exposure Prophylaxis Initiation Among Rural Men Who Have Sex With Men in the Southern United States: Protocol for a Randomized Controlled Trial

Jeb Jones, Georgia Manley, Tiffany R Glynn, Kristin M Wall, Stefan D Baral, E Danny Harris, David Benkeser, Patrick S Sullivan

JMIR Res Protoc 2025;14:e69540

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A Human-Centered Approach for a Student Mental Health and Well-Being Mobile App: Protocol for Development, Implementation, and Evaluation

Moreover, Patrick et al [27] argue that traditional research methods and approaches to digital health interventions overall are inadequate for the increasingly data-rich environment of digital health. They propose an “agile science” approach that emphasizes rapid iteration, ongoing computational modeling, and iterative personalization that dynamically address the complexity inherent in human existence.

Maryam Gholami, David Wing, Manas Satish Bedmutha, Job Godino, Anahi Ibarra, Byron Fergerson, Nicole May, Christopher A Longhurst, Nadir Weibel, Anne Duffy, Heidi Rataj, Karandeep Singh, Kevin Patrick