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Clinical Prediction Models Incorporating Blood Test Trend for Cancer Detection: Systematic Review, Meta-Analysis, and Critical Appraisal

Clinical Prediction Models Incorporating Blood Test Trend for Cancer Detection: Systematic Review, Meta-Analysis, and Critical Appraisal

A total of 6 (29%) of the 14 external validations assessed discrimination, with all using the c-statistic. Birks et al [21] externally validated Colon Flag at multiple time intervals between the most recent blood test and diagnosis in a UK sample, reporting c-statistic=0.844 at 3‐6 months, which reduced to 0.751 at 23‐36 months [21]. Kinar et al [27] also externally validated the Colon Flag using UK data and reported a similar c-statistic (0.81) at 3‐6 months before colorectal cancer diagnosis [27].

Pradeep S Virdee, Kiana K Collins, Claire Friedemann Smith, Xin Yang, Sufen Zhu, Nia Roberts, Jason L Oke, Clare Bankhead, Rafael Perera, FD Richard Hobbs, Brian D Nicholson

JMIR Cancer 2025;11:e70275

Associations Among Minority Stress, Allostatic Load, and Drug and Alcohol Use in Sexual Minorities: Protocol for the Queer Health Study—a Longitudinal Feasibility Evaluation

Associations Among Minority Stress, Allostatic Load, and Drug and Alcohol Use in Sexual Minorities: Protocol for the Queer Health Study—a Longitudinal Feasibility Evaluation

Biomarkers will include immune functioning indicators (IL-1β, -6, and -8, tumor necrosis factor-alpha, C-reactive protein, serum amyloid A, vascular cell adhesion molecule 1, and intercellular cell adhesion molecule 1), metabolic functioning indicators (glycosylated hemoglobin, high-density lipoprotein, and low-density lipoprotein cholesterol, and triglycerides), adiposity (BMI, body fat percent, and waist-to-hip ratio), and blood pressure.

Nathan Grant Smith, Tzuan A Chen, Robert-Paul Juster, Ezemenari M Obasi, Jacob S Crocker

JMIR Res Protoc 2025;14:e73070

Research Dissemination Strategies in Pediatric Emergency Care Using a Professional Twitter (X) Account: A Mixed Methods Developmental Study of a Logic Model Framework

Research Dissemination Strategies in Pediatric Emergency Care Using a Professional Twitter (X) Account: A Mixed Methods Developmental Study of a Logic Model Framework

development (R) Acquisition of external graphics designer (G) Selection of software and metrics (J) Learning to work with existing technologies for scheduling and publishing (AF) Sudden unexpected team member change (U) Outputs Extracting key teaching points from top PECARN articles into tweet (X) Tweet frequency established at the same time each week (3 times per week) (AH) Tweet visual structure: Intentional or strategic polls, emojis, bullet points, and multimedia such as images and videos (AA, AB, AC, C,

Gwendolyn C Hooley, Julia N Magana, Jason M Woods, Shyam Sivasankar, Lauren VonHoltz, Anita R Schmidt, Todd P Chang, Michelle Lin

JMIR Form Res 2025;9:e59481