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Testing the Impact of Intensive, Longitudinal Sampling on Assessments of Statistical Power and Effect Size Within a Heterogeneous Human Population: Natural Experiment Using Change in Heart Rate on Weekends as a Surrogate Intervention

Testing the Impact of Intensive, Longitudinal Sampling on Assessments of Statistical Power and Effect Size Within a Heterogeneous Human Population: Natural Experiment Using Change in Heart Rate on Weekends as a Surrogate Intervention

(E) Time-delay embedding of an individual with greater HR on weekdays. The median pairs of samples required to find a statistically significant difference between weekend night and weekday night HR at P A subset of 8798, 9964, and 12,018 individuals from the dataset of 46,217 individuals did not reach significance in any of the 100 runs of within-individual, within-individual temporal, or within-individual sequential sampling, respectively.

Severine Soltani, Varun K Viswanath, Patrick Kasl, Wendy Hartogensis, Stephan Dilchert, Frederick M Hecht, Ashley E Mason, Benjamin L Smarr

J Med Internet Res 2025;27:e60284

Developing the MyCancerGene Digital Health Portal to Improve Patients’ Understanding of Germline Cancer Genetic Test Results: Development, User, and Usability Testing Study

Developing the MyCancerGene Digital Health Portal to Improve Patients’ Understanding of Germline Cancer Genetic Test Results: Development, User, and Usability Testing Study

(Yes/No).” e“Do you think there would be any challenges with and/or barriers to using a Genetic Health Portal?” f“How likely is it that you would use a Genetic Health Portal?” g Indicates somewhat or very likely on a 5-point Likert scale. Table 4 presents patient feedback on why a GHP might be considered helpful, based on responses from 224 participants.

Phillip Trieu, Dominique Fetzer, Briana McLeod, Kathryn Schweickert, Lauren Gutstein, Brian Egleston, Susan Domchek, Linda Fleisher, Lynne Wagner, Kuang-Yi Wen, Cara Cacioppo, Jessica E Ebrahimzadeh, Dana Falcone, Claire Langer, Elisabeth Wood, Kelsey Karpink, Shelby Posen, Enida Selmani, Angela R Bradbury

JMIR Form Res 2025;9:e56282