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Wang et al [13] differentiated heat and cold patterns in rheumatoid arthritis through cluster and factor analyses to guide clinical medication. Wu et al [48] investigated TCM cold and hot constitutions using pulse wave parameters such as augmentation index and heart rate variability. Although some individual studies have applied artificial intelligence to differentiate cold and hot properties, most efforts have been limited to identifying the properties of Chinese herbal medicines.
JMIR Med Inform 2025;13:e64725
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