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Temporal Dynamics of Subtle Cognitive Change: Validation of a User-Friendly Multidomain Digital Assessment Using an Alcohol Challenge

Temporal Dynamics of Subtle Cognitive Change: Validation of a User-Friendly Multidomain Digital Assessment Using an Alcohol Challenge

Moreover, the burden and cost of administering a full cognitive assessment would likely make such an approach unrealistic. One possible solution to this issue is the development of a digital platform with automated administration/scoring, designed for remote data collection—eliminating the need for participants to visit a clinic [18].

John Frederick Dyer, Florentine Marie Barbey, Ayan Ghoshal, Ann Marie Hake, Bryan J Hansen, Md Nurul Islam, Judith Jaeger, Rouba Kozak, Hugh Marston, Mark Moss, Viet Nguyen, Rebecca Louise Quinn, Leslie A Shinobu, Elizabeth Tunbridge, Brian Murphy, Niamh Kennedy

J Med Internet Res 2025;27:e55469

The Influence of Medical Culture and Key Factors on Mobile App Usage Frequency and Perceived Effectiveness in Physical Therapy: Cross-Sectional Study

The Influence of Medical Culture and Key Factors on Mobile App Usage Frequency and Perceived Effectiveness in Physical Therapy: Cross-Sectional Study

Conversely, a rigid or traditional medical culture can act as a barrier to the usage of new technologies and methods [4]. The role of medical culture extends beyond the attitudes of individual professionals, influencing how teams function and how institutions respond to emerging challenges in health care [5].

Khalid A Alahmari, Ravi Shankar Reddy

J Med Internet Res 2025;27:e68406

Comparison of Multimodal Deep Learning Approaches for Predicting Clinical Deterioration in Ward Patients: Observational Cohort Study

Comparison of Multimodal Deep Learning Approaches for Predicting Clinical Deterioration in Ward Patients: Observational Cohort Study

Overview of unstructured data processing for a single timestep. CUIs are extracted from clinical notes by c TAKES and assembled into a usable data structure that maps encounter ID to a list of CUIs associated with the timestep. A table of CUI-associated data is created, independent of patient data, containing preferred text, ICD codes, Sap BERT embedding, and cluster information.

Charles A Kotula, Jennie Martin, Kyle A Carey, Dana P Edelson, Dmitriy Dligach, Anoop Mayampurath, Majid Afshar, Matthew M Churpek

J Med Internet Res 2025;27:e75340

Relationship of Hair Cortisol Concentration With Perceived and Somatic Stress Indices: Cross-Sectional Pilot Study

Relationship of Hair Cortisol Concentration With Perceived and Somatic Stress Indices: Cross-Sectional Pilot Study

Since cortisol is incorporated into growing hair, hair is emerging as a novel matrix for measuring retrospective cortisol secretion over months [9,11,12]. Each 1 cm hair segment, beginning from the proximal end, approximates a month’s cortisol production.

Sharon H Bergquist, Danyang Wang, Brad Pearce, Alicia K Smith, Allison Hankus, David L Roberts, Miranda A Moore

JMIR Form Res 2025;9:e63811

Implications of Data Extraction and Processing of Electronic Health Records for Epidemiological Research: Observational Study

Implications of Data Extraction and Processing of Electronic Health Records for Epidemiological Research: Observational Study

Nivel-PCD: All insurance claims codes as recorded by the GP are received, however, when a dataset has been requested by the researcher, the codes are filtered by the data processor to include a selection of codes relevant to the study (in agreement with the researchers), on a database zone level. Contacts Defined as moments of contact between a GP and a patient. Based on unique dates on which an insurance claim code was recorded by the GP, that is, the maximum number of contacts per patient per day is 1.

Melissa H J van Essen, Robin Twickler, Yvette M Weesie, Ilgin G Arslan, Feikje Groenhof, Lilian L Peters, Isabelle Bos, Robert A Verheij

J Med Internet Res 2025;27:e64628

Feasibility and Usability of a Web-Based Peer Support Network for Care Partners of People With Serious Illness (ConnectShareCare): Observational Study

Feasibility and Usability of a Web-Based Peer Support Network for Care Partners of People With Serious Illness (ConnectShareCare): Observational Study

Addressing care partner needs is a pressing health, economic, and social imperative. There is a growing literature on web-based peer support networks for care partners of people with serious illness, and such networks typically contain a platform to exchange information and provide peer support [5].

Aricca D Van Citters, Megan M Holthoff, Colleen Young, Sarah M Eck, Amelia M Cullinan, Stephanie Carney, Elizabeth A O'Donnell, Joel R King, Malavika Govindan, David Gustafson, Stephanie C Tomlin, Anne B Holmes, Ann D Bradley, Brant J Oliver, Matthew M Wilson, Eugene C Nelson, Amber E Barnato, Kathryn B Kirkland

JMIR Form Res 2025;9:e70206

Smartphone Ecological Momentary Assessment and Wearable Activity Tracking in Pediatric Depression: Cohort Study

Smartphone Ecological Momentary Assessment and Wearable Activity Tracking in Pediatric Depression: Cohort Study

Exclusion criteria for individuals with MDD included a severe neurodevelopmental disorder or other impairment that impacts the participant’s ability to provide the required information for the study (eg, symptom reports), a substance or medication-induced affective disorder, an affective disorder secondary to a medical condition, and a current Axis I psychotic or bipolar disorder.

Jimena Unzueta Saavedra, Emma A Deaso, Margot Austin, Laura Cadavid, Rachel Kraff, Emma E M Knowles

JMIR Form Res 2025;9:e66187

Chatbot for the Return of Positive Genetic Screening Results for Hereditary Cancer Syndromes: Prompt Engineering Project

Chatbot for the Return of Positive Genetic Screening Results for Hereditary Cancer Syndromes: Prompt Engineering Project

Prior results from the BRIDGE (Broadening the Reach, Impact, and Delivery of Genetic Services) trial showed equivalence between a technology-based chatbot approach and standard of care in the completion of pretest genetics education and completion of genetic testing among unaffected primary care patients meeting criteria for cancer genetic evaluation [20].

Emma Coen, Guilherme Del Fiol, Kimberly A Kaphingst, Emerson Borsato, Jackilen Shannon, Hadley Smith, Aaron Masino, Caitlin G Allen

JMIR Cancer 2025;11:e65848

Caregivers’ Perceptions of Clinical Symptoms, Disease Management, and Quality of Life Impact in Cases of Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Cross-Sectional Online Survey

Caregivers’ Perceptions of Clinical Symptoms, Disease Management, and Quality of Life Impact in Cases of Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: Cross-Sectional Online Survey

However, CDD has a distinct genetic cause and symptom profile, as severe developmental delay is exhibited from birth and seizure onset occurs earlier, and it was thus established as a separate clinical condition in 2013 [3-5]. CDD is caused by pathogenic variants in the X-linked gene CDKL5, which plays a key role in normal brain development and function [6].

Sam Amin, Carol-Anne Partridge, Helen Leonard, Jenny Downs, Helen Allvin, Valentine Ficara, Emilie Pain, Minna A Korolainen

JMIR Form Res 2025;9:e72489

Information Needs for Opioid Use Disorder Treatment Using Buprenorphine Product: Qualitative Analysis of Suboxone-Focused Reddit Data

Information Needs for Opioid Use Disorder Treatment Using Buprenorphine Product: Qualitative Analysis of Suboxone-Focused Reddit Data

To develop a more comprehensive understanding of these challenges, it is essential to analyze posts that involve multiple, overlapping themes and reflect the complexity of real-world experiences. We address this research gap by proposing a theme-driven framework that provides a labeled dataset. A comprehensive analysis is performed on this dataset, covering multiple themes of TINs and capturing Reddit post data from thousands of affected individuals.

Madhusudan Basak, Omar Sharif, Sarah E Lord, Jacob T Borodovsky, Lisa A Marsch, Sandra A Springer, Edward V Nunes, Charles D Brackett, Luke J Archibald, Sarah M Preum

J Med Internet Res 2025;27:e68886