<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="review-article"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Pediatr Parent</journal-id><journal-id journal-id-type="publisher-id">pediatrics</journal-id><journal-id journal-id-type="index">30</journal-id><journal-title>JMIR Pediatrics and Parenting</journal-title><abbrev-journal-title>JMIR Pediatr Parent</abbrev-journal-title><issn pub-type="epub">2561-6722</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v9i1e98889</article-id><article-id pub-id-type="doi">10.2196/98889</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>AI and Chatbot-Supported Interventions for Physical Activity and Obesity-Related Lifestyle Behaviors: Scoping Review With Attention to Family Involvement</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Jiang</surname><given-names>Qianxia</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Chen</surname><given-names>Xiayu Summer</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Patel</surname><given-names>Dev</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Brazendale</surname><given-names>Keith</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Alejandro</surname><given-names>Sualba</given-names></name><degrees>BS</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><institution>Department of Health Sciences, University of Central Florida</institution><addr-line>4364 Scorpius St</addr-line><addr-line>Orlando</addr-line><addr-line>FL</addr-line><country>United States</country></aff><aff id="aff2"><institution>School of Social Work, University of Central Florida</institution><addr-line>Florida</addr-line><country>United States</country></aff><aff id="aff3"><institution>College of Medicine, University of Central Florida</institution><addr-line>Florida</addr-line><country>United States</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Balcarras</surname><given-names>Matthew</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Raeside</surname><given-names>Rebecca</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Kath</surname><given-names>Suraj</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Kwok</surname><given-names>Tyrone Tai-On</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Qianxia Jiang, PhD, Department of Health Sciences, University of Central Florida, 4364 Scorpius St, Orlando, FL, 32816, United States, 1 8609318880; <email>qianxia.jiang@ucf.edu</email></corresp></author-notes><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>24</day><month>7</month><year>2026</year></pub-date><volume>9</volume><elocation-id>e98889</elocation-id><history><date date-type="received"><day>20</day><month>04</month><year>2026</year></date><date date-type="rev-recd"><day>08</day><month>06</month><year>2026</year></date><date date-type="accepted"><day>23</day><month>06</month><year>2026</year></date></history><copyright-statement>&#x00A9; Qianxia Jiang, Xiayu Summer Chen, Dev Patel, Keith Brazendale, Sualba Alejandro. Originally published in JMIR Pediatrics and Parenting (<ext-link ext-link-type="uri" xlink:href="https://pediatrics.jmir.org">https://pediatrics.jmir.org</ext-link>), 24.7.2026. </copyright-statement><copyright-year>2026</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Pediatrics and Parenting, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://pediatrics.jmir.org">https://pediatrics.jmir.org</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://pediatrics.jmir.org/2026/1/e98889"/><abstract><sec><title>Background</title><p>AI-enabled chatbots and related conversational systems can facilitate human&#x2013;computer interaction through natural language, personalization, and automated support. In pediatric health promotion, these tools have the potential to provide scalable and flexible approaches to support physical activity (PA) and related lifestyle behavior change within family contexts. However, evidence regarding AI and chatbot-supported interventions for PA and obesity-related lifestyle behaviors among children and adolescents remains limited, and the extent to which these interventions involve parents, caregivers, or families has not been clearly characterized.</p></sec><sec><title>Objective</title><p>This scoping review aimed to provide an up-to-date overview of how AI and chatbot-supported interventions are designed, delivered, and evaluated for PA and obesity-related lifestyle behaviors among children and adolescents, with attention to technology characteristics, family involvement, delivery platforms, outcomes, and research gaps.</p></sec><sec sec-type="methods"><title>Methods</title><p>In accordance with PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guideline, 7 databases (PubMed, Web of Science, APA PsycINFO, Academic Search Complete, CINAHL Ultimate, IEEE Xplore, and Scopus) were searched through February 2026. Two reviewers independently conducted title and abstract screening, followed by full-text screening in Rayyan (Qatar Computing Research Institute). Eligible studies involved children, adolescents, or families; evaluated an AI-enabled chatbot, conversational agent, or related digital system; and addressed PA, exercise, sedentary behavior, screen time, obesity, overweight, or weight management. Diet, sleep, and other lifestyle outcomes were extracted when reported within otherwise eligible studies. Data were extracted and synthesized narratively in accordance with research objectives.</p></sec><sec sec-type="results"><title>Results</title><p>Of 2730 records identified, 14 studies met inclusion criteria. Most were published in 2023 or later (n=12, 85.7%) and spanned 10 countries. Mobile app delivery was most common (n=9, 64.3%). AI approaches included rule-based chatbots, hybrid personalization systems, generative AI, and single studies using recommender systems or computer vision. A total of 10 studies (71.4%) included a specific parent, caregiver, or family component. Common intervention features were personalized feedback (n=10, 71.4%), self-monitoring (n=9, 64.3%), and education (n=9, 64.3%). PA was the most common target behavior, often within broader obesity or healthy lifestyle interventions. Among 8 studies reporting direct PA or fitness outcomes, 4 showed significant improvement, 2 found no significant change, and 2 reported mixed or indirect findings. Feasibility, acceptability, usability, and engagement findings were generally favorable across studies, but cultural tailoring was reported in only one study.</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>AI and chatbot-supported interventions for pediatric PA and obesity-related lifestyle behaviors represent a rapidly emerging but still early-stage field. Family involvement varies considerably across interventions and should be more clearly conceptualized and evaluated in future studies.</p></sec></abstract><kwd-group><kwd>artificial intelligence</kwd><kwd>chatbot</kwd><kwd>family-based intervention</kwd><kwd>physical activity</kwd><kwd>pediatric obesity</kwd><kwd>lifestyle behaviors</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>Childhood physical inactivity (PA) and obesity are persistent, high-impact challenges across the life course and often cluster within families through shared environments, routines, and resources [<xref ref-type="bibr" rid="ref1">1</xref>]. World Health Organization (WHO) guidelines recommend that children and adolescents accumulate an average of at least 60 minutes per day of moderate-to-vigorous PA, while also reducing sedentary time [<xref ref-type="bibr" rid="ref2">2</xref>]. Yet recent global surveillance indicates that PA levels remain low across childhood and adolescence. Global Matrix 4.0 data from 57 countries suggest that only about 27%-33% of children and adolescents aged 5-17 years meet recommended activity levels [<xref ref-type="bibr" rid="ref3">3</xref>], and the WHO reports that 81% of adolescents aged 11-17 years are insufficiently active worldwide [<xref ref-type="bibr" rid="ref4">4</xref>].</p><p>Pediatric overweight and obesity also represent a growing global public health challenge. In 2022, more than 390 million children and adolescents aged 5-19 years worldwide were living with overweight, including more than 160 million living with obesity. The prevalence of overweight, including obesity, among children and adolescents aged 5&#x2010;19 years increased from 8% in 1990 to 20% in 2022, while the prevalence of obesity alone increased from 2% to 8% [<xref ref-type="bibr" rid="ref5">5</xref>]. Important regional differences are also evident. Latin America and the Caribbean, the Middle East and North Africa, and North America have among the highest prevalence of overweight, while the largest numbers of affected children and adolescents are concentrated in East Asia and the Pacific, Latin America and the Caribbean, and South Asia [<xref ref-type="bibr" rid="ref6">6</xref>]. These patterns reflect broader behavioral, environmental, and structural determinants of health and reinforce the need for accessible and scalable approaches to support healthy behaviors among children, adolescents, and families [<xref ref-type="bibr" rid="ref1">1</xref>].</p><p>Families play a central role in shaping children&#x2019;s health behaviors [<xref ref-type="bibr" rid="ref7">7</xref>]. Caregivers influence opportunities for PA through role modeling, encouragement, co-participation, transportation, and the organization of routines [<xref ref-type="bibr" rid="ref8">8</xref>]. Therefore, family-based approaches are widely recognized as an important strategy for supporting healthy lifestyle behaviors and pediatric obesity prevention and treatment [<xref ref-type="bibr" rid="ref7">7</xref>]. At the same time, participation in intensive family-based programs can be difficult to sustain because of barriers such as cost, scheduling demands, transportation, workforce limitations, and unequal access to care [<xref ref-type="bibr" rid="ref7">7</xref>]. These challenges are particularly relevant for underserved families and have increased interest in more flexible and scalable approaches to family-centered behavior change support.</p><p>Digital health and mHealth have rapidly expanded as a delivery channel for behavior change interventions, supported by widespread mobile device access and increasing interest from health systems in scalable, low-cost approaches [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref10">10</xref>]. Within this broader digital health landscape, conversational tools such as chatbots and virtual agents represent one emerging delivery format that may support health promotion through interactive communication, tailored prompts, and ongoing engagement [<xref ref-type="bibr" rid="ref9">9</xref>,<xref ref-type="bibr" rid="ref10">10</xref>]. However, for pediatric PA and relevant lifestyle behaviors, the literature remains scattered across diverse populations, platforms, intervention designs, and outcomes.</p><p>AI has further expanded the potential of digital health interventions for children and families by enabling more tailored, interactive, and responsive (ie, real-time) support [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref12">12</xref>]. In contrast to static digital content, AI-enabled systems such as chatbots and conversational agents may help deliver intervention components based on user input, preferences, or real-time data [<xref ref-type="bibr" rid="ref13">13</xref>]. In pediatric lifestyle interventions, these features may be especially relevant because children&#x2019;s PA and related behaviors are shaped by changing routines, developmental needs, and family context [<xref ref-type="bibr" rid="ref12">12</xref>]. However, the evidence base remains fragmented across platforms, target behaviors, and outcome measurement strategies [<xref ref-type="bibr" rid="ref14">14</xref>].</p><p>Despite growing interest in AI-enabled digital health tools, few studies have synthesized the current evidence on AI and chatbot-supported interventions for pediatric PA and obesity-related lifestyle behaviors while examining the extent and nature of family involvement [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref13">13</xref>]. Previous reviews have examined conversational agents in health care broadly, chatbot-supported lifestyle interventions across age groups, or the feasibility and acceptability of chatbots for nutrition and PA promotion among adolescents [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref13">13</xref>]. However, these reviews often aggregate adult and pediatric populations, emphasize individual-level interventions, or examine digital health more broadly without distinguishing AI-driven systems from traditional mobile apps [<xref ref-type="bibr" rid="ref10">10</xref>,<xref ref-type="bibr" rid="ref12">12</xref>]. Moreover, family engagement within digital interventions is inconsistently conceptualized and operationalized, ranging from passive caregiver monitoring to active, dyadic, or multigenerational participation [<xref ref-type="bibr" rid="ref12">12</xref>]. Questions also remain regarding cultural responsiveness, equity considerations, accessibility for underserved families, and safeguards related to data privacy, algorithmic bias, transparency, and accountability [<xref ref-type="bibr" rid="ref12">12</xref>]. To address these gaps, the present review focuses specifically on AI and chatbot-supported interventions for pediatric PA and related lifestyle behaviors, with particular attention to family engagement, technology characteristics, cultural tailoring, and implementation gaps.</p><p>Given the rapid evolution of AI technologies and the heterogeneity of study designs, including pilot feasibility trials, randomized controlled trials, and early-stage implementation studies, a scoping review is warranted. Thus, the objective of this scoping review was to map and characterize AI and chatbot-supported interventions targeting pediatric PA and obesity-related lifestyle behaviors. Priority areas of focus are (1) technology type and AI features, (2) delivery platforms and intervention components, (3) definition and operationalization of family engagement, (4) cultural tailoring and bilingual delivery strategies, and (5) the characteristics of the existing evidence base, including study designs, outcomes, and gaps to inform future research and equitable implementation.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Study Design</title><p>A formal review protocol was not prospectively registered. Before screening began, the research team developed the review objectives, eligibility criteria, search strategy, screening procedures, and standardized data-extraction form. The complete database search strategies are provided in <xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>, and the completed PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist is provided in <xref ref-type="supplementary-material" rid="app2">Checklist 1</xref> [<xref ref-type="bibr" rid="ref15">15</xref>]. The review aimed to map and synthesize the existing literature on AI and chatbot-supported interventions targeting pediatric PA and obesity-related lifestyle behaviors, with particular attention to the extent and nature of family involvement.</p></sec><sec id="s2-2"><title>Search Strategy</title><sec id="s2-2-1"><title>Information Sources</title><p>A comprehensive literature search was conducted across 7 electronic databases, including PubMed, Web of Science, APA PsycINFO, Academic Search Complete, CINAHL Ultimate, IEEE Xplore, and Scopus. The final search was performed on February 8, 2026. Searches were limited to English-language peer-reviewed publications published within the past 10 years. This timeframe was selected to capture contemporary AI-enabled and chatbot-supported technologies relevant to current practice, given the rapid evolution of conversational-agent platforms, natural language processing, adaptive personalization, wearable integration, and generative AI. Earlier digital interventions may be less comparable with the systems currently used in pediatric health promotion. The search was limited to peer-reviewed publications indexed in the selected databases. A formal gray-literature search and supplementary backward or forward citation tracking were not conducted.</p></sec><sec id="s2-2-2"><title>Search Terms</title><p>Search strategies were developed to capture three primary domains: (1) AI-enabled conversational technologies, (2) PA and obesity-related outcomes, and (3) child and family populations. Terms for AI technologies included chatbot*, chat bot*, conversational agent*, virtual agent*, relational agent*, virtual assistant*, AI coach*, ChatGPT (OpenAI), large language model*, LLM*, and generative AI. Health-related terms included physical activity*, exercise*, obese*, obesity, overweight, weight management, obesity prevention, sedentary, and screen. Population terms included child*, adolescent*, youth, teen*, pediatric*, family*, parent*, caregiver*, family-based, and parent-based. Database-specific syntax adjustments were applied as needed, including title and abstract field restrictions and wildcard limits. The detailed search history was provided in supplementary material (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>).</p><p>Review articles, systematic reviews, scoping reviews, and meta-analyses were excluded during the search process where possible using database filters.</p></sec></sec><sec id="s2-3"><title>Eligibility Criteria</title><p>Eligibility criteria were guided by the population, intervention, comparator, outcomes, and study design (PICOS) framework. Studies were included if they: (P) involved children or adolescents aged 0&#x2010;18 years or parents, caregivers, or families supporting the health behaviors of a child or adolescent within this age range; (I) evaluated an AI-enabled chatbot, conversational agent, or related digital system designed to support PA or obesity-related lifestyle behaviors; (C) included any comparator, such as usual care or an alternative intervention, or no comparator; (O) reported outcomes related to PA or exercise, sedentary behavior or screen time, obesity, overweight, or weight management; and (S) reported empirical quantitative, qualitative, or mixed methods findings.</p><p>Studies were eligible if they involved children or adolescents or parents, caregivers, or families supporting the health behaviors of children or adolescents. Direct parent or caregiver involvement was not required because family involvement was examined as an analytic dimension rather than an eligibility criterion.</p><p>Studies were excluded if they described general digital health tools without an automated conversational, chatbot, AI-enabled, adaptive, or personalized support component, were purely technical development papers without behavioral outcomes, or were nonempirical publications such as editorials, commentaries, protocols, or review articles. Only studies published in English were included.</p></sec><sec id="s2-4"><title>Study Selection</title><p>All retrieved records were imported into Rayyan (Qatar Computing Research Institute), a web-based systematic review management platform [<xref ref-type="bibr" rid="ref16">16</xref>]. Rayyan was used to manage records, identify potential duplicates, and support blinded title and abstract screening. Potential duplicates identified through bibliographic metadata were manually reviewed and confirmed before removal. Final eligibility decisions were made by the reviewers rather than by the software. Title and abstract screening were conducted independently by 2 reviewers (DP and SA), who were blinded to each other&#x2019;s decisions during the initial screening phase. At this stage, records were excluded if they were clearly unrelated to pediatric, adolescent, or family populations; did not involve AI-enabled chatbots, conversational agents, or related automated digital systems; did not address PA, obesity, sedentary behavior, weight management, or related lifestyle behaviors; or were clearly nonempirical publications. Records were retained for full-text review when eligibility could not be determined from the title and abstract alone. Full-text screening was then conducted independently by 2 reviewers (DP and SA) using the complete eligibility criteria. At this stage, specific reasons for exclusion were recorded. Articles were excluded during full-text review if they did not report PA or related lifestyle outcomes, did not include children, adolescents, parents, caregivers, or families, did not include an AI-enabled or chatbot-supported intervention component, or provided insufficient information to determine eligibility. Disagreements were resolved through discussion, and unresolved disagreements were adjudicated by a third reviewer (QJ). Interrater reliability was assessed using Cohen kappa (&#x03BA;=0.81).</p></sec><sec id="s2-5"><title>Data Extraction and Synthesis</title><p>Data were extracted using a standardized form developed for this review. Extracted variables included publication and study characteristics (author, year, country, design, and sample size); participant characteristics (target population, age, sex, and family involvement); intervention characteristics (intervention type, delivery platform, duration, comparator, wearable or sensor use, and behavior change components); AI-related features (AI or automation role, intervention system or platform, reported AI technique or automation logic, input data type, and AI tasks or outputs); theoretical foundations; and reported outcomes, including feasibility, acceptability, usability, engagement, PA, and related lifestyle outcomes, secondary outcomes, and key findings. Extracted data were synthesized narratively to characterize the scope of the evidence and identify patterns across study design, intervention delivery, AI functionality, family engagement, and outcomes.</p></sec><sec id="s2-6"><title>Critical Appraisal</title><p>A formal critical appraisal or methodological quality assessment was not conducted. The purpose of this scoping review was to map the characteristics, applications, and gaps within an emerging and heterogeneous evidence base rather than to assess the certainty of evidence or estimate pooled intervention effects.</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><sec id="s3-1"><title>Overview</title><p><xref ref-type="fig" rid="figure1">Figure 1</xref> presents the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram. The initial database search identified 2730 records. After removing 363 duplicate records, 2367 unique articles remained for title and abstract screening. Of these, 2231 were excluded because they were clearly outside the review scope. A total of 136 full-text articles were assessed for eligibility. During full-text review, 122 articles were excluded for the following primary reasons: no PA or related lifestyle outcome, not child-, adolescent-, parent-, caregiver-, or family-focused, no AI-enabled or chatbot-supported component, or insufficient information to determine eligibility. Ultimately, 14 studies met the inclusion criteria and were included in the final sample (<xref ref-type="fig" rid="figure1">Figure 1</xref>).</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart for study selection process.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="pediatrics_v9i1e98889_fig01.png"/></fig></sec><sec id="s3-2"><title>Study Overview</title><p>A total of 14 original studies were included in this scoping review [<xref ref-type="bibr" rid="ref17">17</xref>-<xref ref-type="bibr" rid="ref30">30</xref>] (<xref ref-type="table" rid="table1">Table 1</xref>). The studies were published between 2021 and 2026, with 12 of the 14 published in 2023 or later. The 14 studies were conducted across 10 countries. The United States and South Korea were the most frequently represented settings (n=3 each), followed by one study each from Turkey, Spain, Italy, the United Kingdom, Belgium, Switzerland, Greece, and Canada. Although the included studies were geographically diverse, all were conducted in middle- or high-income contexts.</p><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>Characteristics of included studies.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Study and year</td><td align="left" valign="bottom">Country</td><td align="left" valign="bottom">Study design</td><td align="left" valign="bottom">Sample size</td></tr></thead><tbody><tr><td align="left" valign="top">Aydemir (2025) [<xref ref-type="bibr" rid="ref17">17</xref>]</td><td align="left" valign="top">Turkey</td><td align="left" valign="top">Pre-post feasibility study with intervention and control groups</td><td align="left" valign="top">26 parent-child dyads (13 intervention and 13 control)</td></tr><tr><td align="left" valign="top">de Arriba Mu&#x00F1;oz et al (2026) [<xref ref-type="bibr" rid="ref18">18</xref>]</td><td align="left" valign="top">Spain</td><td align="left" valign="top">Prospective single-arm observational pre-post study</td><td align="left" valign="top">40 families or pediatric patients</td></tr><tr><td align="left" valign="top">Emerson et al<break/>(2026) [<xref ref-type="bibr" rid="ref30">30</xref>]</td><td align="left" valign="top">United States</td><td align="left" valign="top">Three-phase qualitative adaptation study</td><td align="left" valign="top">22 total (phase 1: n=6; phase 2: n=4; phase 3: n=12)</td></tr><tr><td align="left" valign="top">Heerman et al<break/>(2024) [<xref ref-type="bibr" rid="ref19">19</xref>]</td><td align="left" valign="top">United States</td><td align="left" valign="top">Multicenter randomized clinical trial</td><td align="left" valign="top">900 parent-infant pairs</td></tr><tr><td align="left" valign="top">Larizza et al<break/>(2023) [<xref ref-type="bibr" rid="ref22">22</xref>]</td><td align="left" valign="top">Italy</td><td align="left" valign="top">App development+pilot usability or acceptability study</td><td align="left" valign="top">13 children</td></tr><tr><td align="left" valign="top">Moore et al<break/>(2024) [<xref ref-type="bibr" rid="ref23">23</xref>]</td><td align="left" valign="top">United Kingdom</td><td align="left" valign="top">Co-design study with mixed methods evaluation</td><td align="left" valign="top">9 co-design participants; 46 evaluation participants</td></tr><tr><td align="left" valign="top">Oh et al<break/>(2022) [<xref ref-type="bibr" rid="ref24">24</xref>]</td><td align="left" valign="top">South Korea</td><td align="left" valign="top">Randomized controlled trial</td><td align="left" valign="top">24 adolescents</td></tr><tr><td align="left" valign="top">Peuters et al<break/>(2024) [<xref ref-type="bibr" rid="ref25">25</xref>]</td><td align="left" valign="top">Belgium</td><td align="left" valign="top">Quasi-randomized controlled trial+process evaluation interviews</td><td align="left" valign="top">279 adolescents; interviews n=13</td></tr><tr><td align="left" valign="top">Stasinaki et al<break/>(2021) [<xref ref-type="bibr" rid="ref26">26</xref>]</td><td align="left" valign="top">Switzerland</td><td align="left" valign="top">Randomized controlled trial</td><td align="left" valign="top">41 recruited; analysis n=31 at baseline after exclusions or dropout</td></tr><tr><td align="left" valign="top">Tan et al<break/>(2026) [<xref ref-type="bibr" rid="ref27">27</xref>]</td><td align="left" valign="top">United States</td><td align="left" valign="top">Single-arm pilot feasibility study</td><td align="left" valign="top">172</td></tr><tr><td align="left" valign="top">Zarkogianni et al<break/>(2023) [<xref ref-type="bibr" rid="ref29">29</xref>]</td><td align="left" valign="top">Greece</td><td align="left" valign="top">Feasibility pilot trial</td><td align="left" valign="top">50 children</td></tr><tr><td align="left" valign="top">Kim et al<break/>(2025) [<xref ref-type="bibr" rid="ref20">20</xref>]</td><td align="left" valign="top">South Korea</td><td align="left" valign="top">User-centered design or development and usability study</td><td align="left" valign="top">Needs survey n=96; interviews n=30; UI usability n=76</td></tr><tr><td align="left" valign="top">Kang et al<break/>(2026) [<xref ref-type="bibr" rid="ref21">21</xref>]</td><td align="left" valign="top">South Korea</td><td align="left" valign="top">Descriptive comparative cross-sectional survey study</td><td align="left" valign="top">160 total (80 childhood or adolescent cancer survivors &#x003E;80 parents)</td></tr><tr><td align="left" valign="top">Willms and Liu<break/>(2024) [<xref ref-type="bibr" rid="ref28">28</xref>]</td><td align="left" valign="top">Canada</td><td align="left" valign="top">Autoethnographic feasibility case study or development paper</td><td align="left" valign="top">No human participants; content development case study</td></tr></tbody></table></table-wrap><p>Among included studies, 3 studies were randomized controlled trials [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref26">26</xref>], one was quasi-randomized [<xref ref-type="bibr" rid="ref25">25</xref>], one was a pre-post feasibility study with a comparison group [<xref ref-type="bibr" rid="ref17">17</xref>], and 3 were single-arm or uncontrolled pilot or pre-post studies [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref27">27</xref>]. The remaining 6 were noneffectiveness-focused designs, including one qualitative adaptation study [<xref ref-type="bibr" rid="ref30">30</xref>], one co-design mixed methods study [<xref ref-type="bibr" rid="ref23">23</xref>], 2 development or usability studies [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref28">28</xref>], one cross-sectional survey [<xref ref-type="bibr" rid="ref21">21</xref>], and one autoethnographic feasibility or development paper [<xref ref-type="bibr" rid="ref29">29</xref>]. Sample sizes ranged from 9 to 900 participants, with most studies enrolling relatively small samples; only one large, randomized trial included more than 500 participants [<xref ref-type="bibr" rid="ref19">19</xref>].</p></sec><sec id="s3-3"><title>Participant and Family Characteristics</title><p>The 14 studies targeted a broad range of pediatric populations, including infants, school-aged children, and adolescents (<xref ref-type="table" rid="table2">Table 2</xref>). Most studies focused on school-aged children or adolescents, whereas one large trial focused on infants from birth to 24 months [<xref ref-type="bibr" rid="ref19">19</xref>]. Several studies targeted specific clinical or high-need populations, including youth with autism spectrum disorder (n=2) [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref30">30</xref>], children or adolescents with obesity or overweight (n=5) [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref29">29</xref>], childhood or adolescent cancer survivors (n=1) [<xref ref-type="bibr" rid="ref21">21</xref>], and adolescents facing barriers to PA or living in under-resourced settings (n=2) [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref27">27</xref>].</p><table-wrap id="t2" position="float"><label>Table 2.</label><caption><p>Participant and family characteristics of included studies.</p></caption><table id="table2" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom" colspan="2">Study and<break/>Year</td><td align="left" valign="bottom">Target population or unit of Intervention</td><td align="left" valign="bottom">Population characteristics or special group</td><td align="left" valign="bottom">Child age</td><td align="left" valign="bottom">Parent age</td><td align="left" valign="bottom">Sex (female), n (%)</td><td align="left" valign="bottom">Language</td><td align="left" valign="bottom">Cultural tailoring</td></tr></thead><tbody><tr><td align="left" valign="top" colspan="2">Aydemir (2025) [<xref ref-type="bibr" rid="ref17">17</xref>]</td><td align="left" valign="top">Parent-child dyads</td><td align="left" valign="top">Children with autism spectrum disorder (ASD)</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention: mean 14.38 (SD 3.06)</p></list-item><list-item><p>Control: mean 13.92 (SD 3.52)</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intervention: mean 42.84 (SD 7.70)</p></list-item><list-item><p>Control: mean 44.07 (SD 7.95)</p></list-item></list></td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Children: intervention 6/13 (46%), control 8/13 (62%)</p></list-item><list-item><p>Parents: intervention 5/13 (38%), control 4/13 (31%)</p></list-item></list></td><td align="left" valign="top">Likely Turkish / ChatGPT (OpenAI)-supported text prompts</td><td align="left" valign="top">NR<sup><xref ref-type="table-fn" rid="table2fn1">a</xref></sup></td></tr><tr><td align="left" valign="top" colspan="2">de Arriba Mu&#x00F1;oz et al (2026) [<xref ref-type="bibr" rid="ref18">18</xref>]</td><td align="left" valign="top">Family (caregiver+ child or adolescent)</td><td align="left" valign="top">Children or adolescents with obesity receiving GLP-1<sup><xref ref-type="table-fn" rid="table2fn2">b</xref></sup> therapy</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Mean 14.05 (SD 1.04) years</p></list-item></list></td><td align="left" valign="top">NR</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>25/40 (62.5%)</p></list-item></list></td><td align="left" valign="top">Spanish</td><td align="left" valign="top">NR</td></tr><tr><td align="left" valign="top" colspan="2">Emerson et al<break/>(2026) [<xref ref-type="bibr" rid="ref30">30</xref>]</td><td align="left" valign="top">Youth with ASD and caregivers; providers or therapists</td><td align="left" valign="top">Youth with autism spectrum disorder at risk of obesity</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Youth with ASD; exact ages not reported in abstract</p></list-item></list></td><td align="left" valign="top">NR</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>NR</p></list-item></list></td><td align="left" valign="top">English</td><td align="left" valign="top">NR</td></tr><tr><td align="left" valign="top" colspan="2">Heerman et al (2024) [<xref ref-type="bibr" rid="ref19">19</xref>]</td><td align="left" valign="top">Parent-child dyads</td><td align="left" valign="top">Infants from racially and ethnically diverse US families</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Birth-24 months follow-up</p></list-item></list></td><td align="left" valign="top">Adults &#x2265;18 years</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Children: intervention: 243/449 (54.1%)</p></list-item><list-item><p>Control: 233/451 (51.7%) female</p></list-item></list></td><td align="left" valign="top">English and Spanish</td><td align="left" valign="top">Yes; all content translated into Spanish and assessed for cultural appropriateness</td></tr><tr><td align="left" valign="top" colspan="2">Larizza et al<break/>(2023) [<xref ref-type="bibr" rid="ref22">22</xref>]</td><td align="left" valign="top">Child and parent</td><td align="left" valign="top">Children with obesity</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Age: 6&#x2010;12 years</p></list-item><list-item><p>Mean 9.3 (SD 1.3) years</p></list-item></list></td><td align="left" valign="top">NR</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>5/13 (38.5%)</p></list-item></list></td><td align="left" valign="top">Italian context</td><td align="left" valign="top">NR</td></tr><tr><td align="left" valign="top" colspan="2">Moore et al<break/>(2024) [<xref ref-type="bibr" rid="ref23">23</xref>]</td><td align="left" valign="top">Adolescents</td><td align="left" valign="top">Adolescents facing barriers to physical activity</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>11&#x2010;13 years (co-design)</p></list-item><list-item><p>Adolescents in evaluation</p></list-item></list></td><td align="left" valign="top">NR</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Co-design group 5/9 (56%)</p></list-item></list></td><td align="left" valign="top">English</td><td align="left" valign="top">Personalization emphasized; no cultural tailoring reported</td></tr><tr><td align="left" valign="top" colspan="2">Oh et al<break/>(2022) [<xref ref-type="bibr" rid="ref24">24</xref>]</td><td align="left" valign="top">Adolescents</td><td align="left" valign="top">Adolescents with obesity</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>10&#x2010;17 years</p></list-item><list-item><p>Mean 13.2 (SD 3.6)</p></list-item></list></td><td align="left" valign="top">NR</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>4/24 (16.7%)</p></list-item></list></td><td align="left" valign="top">Korean context</td><td align="left" valign="top">NR</td></tr><tr><td align="left" valign="top" colspan="2">Peuters et al<break/>(2024) [<xref ref-type="bibr" rid="ref25">25</xref>]</td><td align="left" valign="top">Adolescents</td><td align="left" valign="top">General population adolescents aged 12&#x2010;15 during COVID-19 restrictions</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>12&#x2010;15 years</p></list-item></list></td><td align="left" valign="top">NR</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>NR</p></list-item></list></td><td align="left" valign="top">Dutch</td><td align="left" valign="top">Human-centered development; no explicit cultural tailoring</td></tr><tr><td align="left" valign="top" colspan="2">Stasinaki et al<break/>(2021) [<xref ref-type="bibr" rid="ref26">26</xref>]</td><td align="left" valign="top">Youth or adolescents</td><td align="left" valign="top">Youth with overweight or obesity receiving specialist obesity care</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>10&#x2010;18 years</p></list-item><list-item><p>Median baseline age 13.6 years (range 10.9 - 16.9)</p></list-item></list></td><td align="left" valign="top">NR</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>13/31 (41.9%)</p></list-item></list></td><td align="left" valign="top">German/Swiss context</td><td align="left" valign="top">NR</td></tr><tr><td align="left" valign="top" colspan="2">Tan et al<break/>(2026) [<xref ref-type="bibr" rid="ref27">27</xref>]</td><td align="left" valign="top">Children or adolescents</td><td align="left" valign="top">Primarily sixth-grade students in socioeconomically disadvantaged schools</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Mostly 12 years</p></list-item><list-item><p>Range 11&#x2010;15 years</p></list-item></list></td><td align="left" valign="top">NR</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>96/172 (55.8%)</p></list-item></list></td><td align="left" valign="top">English</td><td align="left" valign="top">NR</td></tr><tr><td align="left" valign="top" colspan="2">Zarkogianni et al<break/>(2023) [<xref ref-type="bibr" rid="ref29">29</xref>]</td><td align="left" valign="top">Child and parent</td><td align="left" valign="top">Overweight or obese children</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Mean 10.5 (SD 2.00) years</p></list-item></list></td><td align="left" valign="top">NR</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>26/50 (52%)</p></list-item></list></td><td align="left" valign="top">Greek context</td><td align="left" valign="top">NR</td></tr><tr><td align="left" valign="top" colspan="2">Kim et al<break/>(2025) [<xref ref-type="bibr" rid="ref20">20</xref>]</td><td align="left" valign="top">Adolescents + parents + school health teachers</td><td align="left" valign="top">Middle school adolescents in school-based health management context</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>First-year middle school students or adolescents</p></list-item></list></td><td align="left" valign="top">Range 30&#x2010;59 years</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Students 23/36 (65%)</p></list-item><list-item><p>Parents 25/40 (83%)</p></list-item><list-item><p>Teachers 30/30 (100%)</p></list-item></list></td><td align="left" valign="top">Korean</td><td align="left" valign="top">Designed for Korean school context</td></tr><tr><td align="left" valign="top" colspan="2">Kang et al<break/>(2026) [<xref ref-type="bibr" rid="ref21">21</xref>]</td><td align="left" valign="top">Childhood or adolescent cancer survivors and parents</td><td align="left" valign="top">Childhood or adolescent cancer survivors (aged 10&#x2010;16 years) recruited via the Korean Pediatric Cancer Foundation; survivor-parent perspectives</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Mean 12.1 (SD 2.0) years</p></list-item><list-item><p>Eligibility 10&#x2010;16 years</p></list-item></list></td><td align="left" valign="top">Mean 44.7 (SD 4.2) years</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>CACSs<sup><xref ref-type="table-fn" rid="table2fn3">c</xref></sup> 41/80 (51.2%);</p></list-item><list-item><p>Parent respondents 76/80 (95.0%)</p></list-item></list></td><td align="left" valign="top">Korean</td><td align="left" valign="top">South Korean childhood cancer survivorship context; no explicit cultural tailoring intervention because no chatbot program was deployed</td></tr><tr><td align="left" valign="top" colspan="2">Willms and Liu<break/>(2024) [<xref ref-type="bibr" rid="ref28">28</xref>]</td><td align="left" valign="top">Parents supporting child physical activity (intended target)</td><td align="left" valign="top">Family-based PA<sup><xref ref-type="table-fn" rid="table2fn4">d</xref></sup> content development for children aged 8&#x2010;12 and parents</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>Intended target: children 8&#x2010;12 years</p></list-item></list></td><td align="left" valign="top">NR</td><td align="left" valign="top"><list list-type="bullet"><list-item><p>NR</p></list-item></list></td><td align="left" valign="top">English</td><td align="left" valign="top">NR</td></tr></tbody></table><table-wrap-foot><fn id="table2fn1"><p><sup>a</sup>NR: not reported.</p></fn><fn id="table2fn2"><p><sup>b</sup>GLP-1: glucagon-like peptide-1. </p></fn><fn id="table2fn3"><p><sup>c</sup>CACS: childhood or adolescent cancer survivor.</p></fn><fn id="table2fn4"><p><sup>d</sup>PA: physical activity.</p></fn></table-wrap-foot></table-wrap><p>Ten [<xref ref-type="bibr" rid="ref17">17</xref>-<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref28">28</xref>-<xref ref-type="bibr" rid="ref30">30</xref>] of the 14 studies included a parent, caregiver, or family component in the target population or intervention design, such as parent-child dyads, family-based obesity management, or studies collecting both child and caregiver perspectives. The remaining 4 [<xref ref-type="bibr" rid="ref22">22</xref>-<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref27">27</xref>] were primarily youth-focused, although family influence was acknowledged as an important contextual factor. The degree of family involvement varied considerably, ranging from minimal parental support or consent to parent-mediated delivery, co-participation in activities, shared monitoring, and parent-facing intervention interfaces.</p><p>Reporting of demographic and contextual characteristics was inconsistent. Child age was available in all 14 studies. While parents&#x2019; age was reported in only 4 studies [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref19">19</xref>-<xref ref-type="bibr" rid="ref21">21</xref>]. Female participation or sex distribution was reported in 11 studies [<xref ref-type="bibr" rid="ref17">17</xref>-<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref29">29</xref>]. Among studies reporting child sex distribution, the proportion of female participants ranged from 16.7% to 65.0% [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref24">24</xref>]. Language or linguistic context could be identified in all 14 studies. However, cultural tailoring was reported in only one study [<xref ref-type="bibr" rid="ref19">19</xref>], and 4 additional studies [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref30">30</xref>] described some form of contextual, linguistic, developmental, or population-specific tailoring.</p></sec><sec id="s3-4"><title>Intervention Design and Delivery Characteristics</title><p>Intervention design and delivery characteristics were presented in <xref ref-type="table" rid="table3">Table 3</xref>. Mobile app&#x2013; or smartphone-based delivery was the most common format, appearing in 9 studies [<xref ref-type="bibr" rid="ref17">17</xref>-<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref24">24</xref>-<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref29">29</xref>]. Six studies [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref28">28</xref>-<xref ref-type="bibr" rid="ref30">30</xref>] incorporated a clearly web-based component, such as a dashboard, web platform, online interface, or browser-based system. Other delivery modes included chatbot-supported platforms, WhatsApp (Meta)-supported programming, SMS text messaging or responsive text messaging, serious games, metaverse-supported systems, and hybrid platforms integrating child-, parent-, and clinician-facing tools.</p><table-wrap id="t3" position="float"><label>Table 3.</label><caption><p>Intervention design and delivery characteristics.</p></caption><table id="table3" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom" colspan="2">Study and<break/>year</td><td align="left" valign="bottom">Intervention type</td><td align="left" valign="bottom">Platform or delivery mode</td><td align="left" valign="bottom">Intervention duration</td><td align="left" valign="bottom">Wearable or sensor used</td><td align="left" valign="bottom">Family involvement</td><td align="left" valign="bottom">Comparator or Control</td><td align="left" valign="bottom">Intervention components or behavior change features</td></tr></thead><tbody><tr><td align="left" valign="top" colspan="2">Aydemir (2025) [<xref ref-type="bibr" rid="ref17">17</xref>]</td><td align="left" valign="top">ChatGPT (OpenAI)-delivered, parent-mediated home PA<sup><xref ref-type="table-fn" rid="table3fn1">a</xref></sup> intervention</td><td align="left" valign="top">ChatGPT+parent training+WhatsApp (Meta) support</td><td align="left" valign="top">4 weeks; 40 min/session; 3 days/week</td><td align="left" valign="top">None</td><td align="left" valign="top">High; parents implemented activities and could involve siblings or family</td><td align="left" valign="top">Non-ChatGPT control group</td><td align="left" valign="top">Parent training; home PA plans; warm-up, main, or cool-down; co-participation; WhatsApp support; rewards</td></tr><tr><td align="left" valign="top" colspan="2">de Arriba Mu&#x00F1;oz et al (2026) [<xref ref-type="bibr" rid="ref18">18</xref>]</td><td align="left" valign="top">Family digital support program adjunct to semaglutide</td><td align="left" valign="top">Adhera Caring Digital Program mobile app (Adhera Health, Inc.)</td><td align="left" valign="top">10-month active intervention; interim results at 150 days</td><td align="left" valign="top">Fitbit Inspire 3 (Google LLC)</td><td align="left" valign="top">High; caregiver-focused education, behavior support, and monitoring</td><td align="left" valign="top">None</td><td align="left" valign="top">Education; motivational messaging; progress feedback; wearable monitoring; psychometrics</td></tr><tr><td align="left" valign="top" colspan="2">Emerson et al<break/>(2026) [<xref ref-type="bibr" rid="ref30">30</xref>]</td><td align="left" valign="top">Adaptation of WeChat (Tencent Holdings Limited) chatbot for ASD<sup><xref ref-type="table-fn" rid="table3fn3">c</xref></sup> accessibility</td><td align="left" valign="top">Text or email chatbot concept; interviews or focus groups</td><td align="left" valign="top">Not an intervention trial; exploratory qualitative study</td><td align="left" valign="top">Not central; some participants discussed Fitbit or Apple Watch use</td><td align="left" valign="top">High; family-centered care identified as essential</td><td align="left" valign="top">None</td><td align="left" valign="top">SMART<sup><xref ref-type="table-fn" rid="table3fn2">b</xref></sup> goals; SDOH<sup><xref ref-type="table-fn" rid="table3fn4">d</xref></sup> screening; health resources; adaptation recommendations; branching logic</td></tr><tr><td align="left" valign="top" colspan="2">Heerman et al<break/>(2024) [<xref ref-type="bibr" rid="ref19">19</xref>]</td><td align="left" valign="top">Digital obesity prevention added to primary care counseling</td><td align="left" valign="top">Responsive text messages+web dashboard+clinic counseling</td><td align="left" valign="top">24 months</td><td align="left" valign="top">None</td><td align="left" valign="top">High; parents were the direct intervention users</td><td align="left" valign="top">Clinic-only counseling group</td><td align="left" valign="top">Goal setting; self-monitoring; tailored feedback; dashboard; growth charts; health literacy materials</td></tr><tr><td align="left" valign="top" colspan="2">Larizza et al<break/>(2023) [<xref ref-type="bibr" rid="ref22">22</xref>]</td><td align="left" valign="top">mHealth<sup><xref ref-type="table-fn" rid="table3fn5">e</xref></sup> lifestyle improvement app</td><td align="left" valign="top">Smartphone app+physician or admin dashboard+chatbot</td><td align="left" valign="top">2-week home pilot after training</td><td align="left" valign="top">None</td><td align="left" valign="top">High; parents register child, enter data, monitor trends, support use</td><td align="left" valign="top">None</td><td align="left" valign="top">Goals; education; success stories; monthly questionnaires; diaries; badges; quizzes; avatar; chatbot</td></tr><tr><td align="left" valign="top" colspan="2">Moore et al<break/>(2024) [<xref ref-type="bibr" rid="ref23">23</xref>]</td><td align="left" valign="top">Conversational agent to overcome PA barriers</td><td align="left" valign="top">Web or text-based conversational agent</td><td align="left" valign="top">Prototype evaluation; not long-term intervention</td><td align="left" valign="top">None</td><td align="left" valign="top">Low or minimal</td><td align="left" valign="top">None</td><td align="left" valign="top">Barrier identification; confidence and motivation modules; social dialogue; links or resources; personalization</td></tr><tr><td align="left" valign="top" colspan="2">Oh et al<break/>(2022) [<xref ref-type="bibr" rid="ref24">24</xref>]</td><td align="left" valign="top">AI-based interactive home exercise exergame</td><td align="left" valign="top">Smartphone-based gesture-recognition game versus Nintendo Switch Ring Fit (Nintendo Co., Ltd.)</td><td align="left" valign="top">3 weeks; 30 min/session, 5 days/week</td><td align="left" valign="top">Camera or computer vision gesture recognition</td><td align="left" valign="top">Low or minimal</td><td align="left" valign="top">Nintendo Switch exercise game</td><td align="left" valign="top">Gamified exercise; real-time visual or auditory feedback; alarms; posture feedback</td></tr><tr><td align="left" valign="top" colspan="2">Peuters et al<break/>(2024) [<xref ref-type="bibr" rid="ref25">25</xref>]</td><td align="left" valign="top">Multicomponent healthy lifestyle or mental health app</td><td align="left" valign="top">LifeGoals (The University of Michigan) mobile app+Fitbit+videos+chatbot</td><td align="left" valign="top">12 weeks</td><td align="left" valign="top">Fitbit Charge 2/3 (intervention); Axivity accelerometers for measurement</td><td align="left" valign="top">Low or minimal direct family role</td><td align="left" valign="top">No-intervention control group</td><td align="left" valign="top">Goal setting; action or coping planning; self-monitoring; rewards; gamification; narrative videos; chatbot; information</td></tr><tr><td align="left" valign="top" colspan="2">Stasinaki et al<break/>(2021) [<xref ref-type="bibr" rid="ref26">26</xref>]</td><td align="left" valign="top">Conversational agent obesity management app+ reduced on-site counseling</td><td align="left" valign="top">PathMate2 mobile app+clinic visits</td><td align="left" valign="top">5.5-month intensive phase +6-month maintenance (12 mo total)</td><td align="left" valign="top">None mentioned for intervention</td><td align="left" valign="top">Moderate; family part of counseling context but youth-focused app</td><td align="left" valign="top">Standard multicomponent behavior change intervention</td><td align="left" valign="top">Daily chatbot counseling; step or activity challenges; meal photos; breathing exercises; goal setting; educational handouts</td></tr><tr><td align="left" valign="top" colspan="2">Tan et al<break/>(2026) [<xref ref-type="bibr" rid="ref27">27</xref>]</td><td align="left" valign="top">AI-assisted school-based health behavior chatbot or web app</td><td align="left" valign="top">Web-based app on school laptops</td><td align="left" valign="top">8 weeks</td><td align="left" valign="top">None</td><td align="left" valign="top">Low; parental consent but no active family component</td><td align="left" valign="top">None</td><td align="left" valign="top">SMART goals; self-monitoring; behavior logging; reflections; AI feedback; progress charts; daily reports; education</td></tr><tr><td align="left" valign="top" colspan="2">Zarkogianni et al<break/>(2023) [<xref ref-type="bibr" rid="ref29">29</xref>]</td><td align="left" valign="top">Family-based mHealth + AI+serious game obesity management platform</td><td align="left" valign="top">Serious game+child app+parent app+clinician app+activity tracker</td><td align="left" valign="top">3 months (12 wk)</td><td align="left" valign="top">Fitbit Ace 2</td><td align="left" valign="top">High; parent app, personalized messages to mothers, family-based intervention</td><td align="left" valign="top">Active control and intervention versions of platform in pilot sequence</td><td align="left" valign="top">Self-monitoring; serious games; personalized messages; meal plans; PA and sleep tracking; clinician/nutritionist support</td></tr><tr><td align="left" valign="top" colspan="2">Kim et al<break/>(2025) [<xref ref-type="bibr" rid="ref20">20</xref>]</td><td align="left" valign="top">Smart health care service design using metaverse, chatbot, wearable, and web or app ecosystem</td><td align="left" valign="top">Student app+parent app+teacher web+metaverse+chatbot+wearable</td><td align="left" valign="top">Development study; no intervention exposure period</td><td align="left" valign="top">Planned wearable device or smartwatch integration</td><td align="left" valign="top">High; parent app and parent participation central in service design</td><td align="left" valign="top">None</td><td align="left" valign="top">Tracking; personalized services; gamification; rewards; consultation; school and parent interfaces</td></tr><tr><td align="left" valign="top" colspan="2">Kang et al<break/>(2026) [<xref ref-type="bibr" rid="ref21">21</xref>]</td><td align="left" valign="top">Cross-sectional assessment of healthy lifestyle practices and acceptability of AI chatbot use for future lifestyle management; no active intervention delivered</td><td align="left" valign="top">Online web-based survey (Google Forms); chatbot was discussed conceptually, not deployed</td><td align="left" valign="top">Cross-sectional survey</td><td align="left" valign="top">None</td><td align="left" valign="top">High for assessment purposes; survivor and parent perspectives were both collected to inform future family-tailored chatbot support</td><td align="left" valign="top">Survivors versus parents (comparative groups); no intervention control</td><td align="left" valign="top">Healthy lifestyle assessment across 7 domains; chatbot awareness or acceptability assessment; open-ended unmet-need responses analyzed with topic modeling</td></tr><tr><td align="left" valign="top" colspan="2">Willms and Liu<break/>(2024) [<xref ref-type="bibr" rid="ref28">28</xref>]</td><td align="left" valign="top">JITAI<sup><xref ref-type="table-fn" rid="table3fn6">f</xref></sup> content development using ChatGPT</td><td align="left" valign="top">ChatGPT-3+ Pathverse no-code mobile app builder</td><td align="left" valign="top">10-week planned JITAI; development process over 2 months</td><td align="left" valign="top">Intended JITAI used child MVPA<sup><xref ref-type="table-fn" rid="table3fn7">g</xref></sup> minutes as decision input; no specific wearable evaluated in case study</td><td align="left" valign="top">High; parent supports child PA</td><td align="left" valign="top">None</td><td align="left" valign="top">Tailored lessons; decision-tree personalization; family PA challenges</td></tr></tbody></table><table-wrap-foot><fn id="table3fn1"><p><sup>a</sup>PA: physical activity.</p></fn><fn id="table3fn2"><p><sup>b</sup>SMART: Specific, Measurable, Achievable, Relevant, and Time-bound.</p></fn><fn id="table3fn3"><p><sup>c</sup>ASD: autism spectrum disorder..</p></fn><fn id="table3fn4"><p><sup>d</sup>SDOH: Social determinants of health</p></fn><fn id="table3fn5"><p><sup>e</sup>mHealth: mobile health.</p></fn><fn id="table3fn6"><p><sup>f</sup>JITAI: Just-in-Time Adaptive Intervention.</p></fn><fn id="table3fn7"><p><sup>g</sup>MVPA: moderate to vigorous physical activity.</p></fn></table-wrap-foot></table-wrap><p>Nine studies [<xref ref-type="bibr" rid="ref17">17</xref>-<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref24">24</xref>-<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref29">29</xref>] reported a defined intervention or exposure period, with durations ranging from 2 weeks to 24 months. Four studies [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref27">27</xref>] had relatively short intervention periods of 2-4 weeks, 3 [<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref29">29</xref>] lasted approximately 8-12 weeks, and 2 [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>] extended beyond 5 months, including one 24-month randomized trial and one 12-month obesity management program. The remaining 5 studies [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref30">30</xref>] were qualitative, developmental, survey-based, or case-based and therefore did not involve a conventional intervention period.</p><p>Most interventions were multicomponent and incorporated established behavior change strategies. Self-monitoring or tracking components were present in 9 studies [<xref ref-type="bibr" rid="ref18">18</xref>-<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref25">25</xref>-<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref29">29</xref>], personalized feedback or adaptive content in 10 studies [<xref ref-type="bibr" rid="ref17">17</xref>-<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref25">25</xref>-<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref30">30</xref>], and education or informational support in 9 studies [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref21">21</xref>-<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref25">25</xref>-<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref30">30</xref>]. Goal setting or challenge-based components were identified in 7 studies [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref25">25</xref>-<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref30">30</xref>], gamification or reward-related elements in 7 studies [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref24">24</xref>-<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref29">29</xref>], and social support, co-participation, or human-supported features in 8 studies [<xref ref-type="bibr" rid="ref17">17</xref>-<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref30">30</xref>]. Reminders or prompts were described as a distinct feature in 4 studies [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref27">27</xref>]. Although all studies were relevant to PA, only 5 [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref28">28</xref>] focused primarily on PA or exercise promotion; the remaining 9 [<xref ref-type="bibr" rid="ref18">18</xref>-<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref30">30</xref>] embedded PA within broader obesity-management, lifestyle, rehabilitation, or healthy living interventions.</p><p>Wearable devices, sensor-based inputs, or objective digital monitoring were reported in 6 studies [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref27">27</xref>-<xref ref-type="bibr" rid="ref29">29</xref>]. These included Fitbit (Google LLC) devices, accelerometers, computer vision&#x2013;based gesture recognition, smartphone- or app-linked monitoring, and planned smartwatch integration. However, most studies still relied partly or primarily on self-reported behavior, questionnaires, or user-entered information.</p></sec><sec id="s3-5"><title>AI Features and Functional Characteristics</title><p>The included studies varied substantially in the sophistication and reporting of their AI and automation features (<xref ref-type="table" rid="table4">Table 4</xref>). To improve clarity, we distinguished the named intervention system or platform from the reported AI technique or automation logic. Three studies [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref28">28</xref>] used generative AI or large language model&#x2013;based approaches directly in intervention delivery or content development. Several studies used scripted, predefined, or automated chatbots and tailoring functions based on structured pathways, branching logic, or automated rules [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref30">30</xref>]. Moore et al [<xref ref-type="bibr" rid="ref23">23</xref>] described natural language understanding for intent recognition and dialogue routing. The study by de Arriba Mu&#x00F1;oz et al [<xref ref-type="bibr" rid="ref18">18</xref>] used a hybrid personalization engine, Zarkogianni et al [<xref ref-type="bibr" rid="ref29">29</xref>] used a machine learning&#x2013;based recommendation system, Oh et al [<xref ref-type="bibr" rid="ref24">24</xref>] used computer vision and deep learning for gesture recognition, and Kim et al [<xref ref-type="bibr" rid="ref20">20</xref>] described a broader integrated chatbot-supported digital health ecosystem.</p><table-wrap id="t4" position="float"><label>Table 4.</label><caption><p>AI features and functional characteristics of the included interventions.</p></caption><table id="table4" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Study</td><td align="left" valign="bottom">Year</td><td align="left" valign="bottom">AI or automation role</td><td align="left" valign="bottom">Intervention system or platform</td><td align="left" valign="bottom">Reported AI technique or automation logic</td><td align="left" valign="bottom">Input data type</td><td align="left" valign="bottom">AI task</td><td align="left" valign="bottom">AI contribution/claimed benefit</td><td align="left" valign="bottom">AI explainability/transparency reported</td></tr></thead><tbody><tr><td align="left" valign="top">Aydemir [<xref ref-type="bibr" rid="ref17">17</xref>]</td><td align="left" valign="top">2025</td><td align="left" valign="top">Generates individualized home physical activity plans and answers parent follow-up questions</td><td align="left" valign="top">ChatGPT-4 (OpenAI)</td><td align="left" valign="top">Generative AI using a large language model</td><td align="left" valign="top">Parent text prompts; child age; and ASD<sup><xref ref-type="table-fn" rid="table4fn2">b</xref></sup> status</td><td align="left" valign="top">Text generation; PA<sup><xref ref-type="table-fn" rid="table4fn1">a</xref></sup> recommendation; instructional clarification</td><td align="left" valign="top">Low-cost, home-based, scalable PA guidance for ASD families</td><td align="left" valign="top">Limited; prompts described but model logic not detailed</td></tr><tr><td align="left" valign="top">de Arriba Mu&#x00F1;oz et al [<xref ref-type="bibr" rid="ref18">18</xref>]</td><td align="left" valign="top">2026</td><td align="left" valign="top">Personalizes caregiver support content</td><td align="left" valign="top">Adhera AI Precision Digital Companion (Adhera Health, Inc)</td><td align="left" valign="top">Hybrid personalization engine; specific algorithm not fully reported</td><td align="left" valign="top">App engagement data; psychometrics; wearable metrics; clinical data</td><td align="left" valign="top">Personalization; feedback; progress support</td><td align="left" valign="top">Complement pharmacotherapy with scalable caregiver support and monitoring</td><td align="left" valign="top">Limited</td></tr><tr><td align="left" valign="top">Emerson et al [<xref ref-type="bibr" rid="ref30">30</xref>]</td><td align="left" valign="top">2026</td><td align="left" valign="top">Delivers health prompts, screening questions, and resources</td><td align="left" valign="top">WE CHAT (Wellness Education to Create Healthy Habits and Actions to Thrive)</td><td align="left" valign="top">Predefined chatbot pathways or branching logic; underlying algorithm not fully reported</td><td align="left" valign="top">User responses to prompts; provider recommendations for adaptation</td><td align="left" valign="top">Goal support; screening; resource/referral prompts</td><td align="left" valign="top">Potential to support obesity prevention for youth with ASD if adapted for variability and caregiver burden</td><td align="left" valign="top">Moderate; logic and use described conceptually</td></tr><tr><td align="left" valign="top">Heerman et al [<xref ref-type="bibr" rid="ref19">19</xref>]</td><td align="left" valign="top">2024</td><td align="left" valign="top">Provides automated tailoring and adaptive feedback</td><td align="left" valign="top">Greenlight Plus digital platform (Vanderbilt University Medical Center)</td><td align="left" valign="top">Automated tailoring using predefined logic; no machine learning model or large language model reported</td><td align="left" valign="top">Parent surveys; goal progress self-ratings; child anthropometrics</td><td align="left" valign="top">Tailored messaging; adaptive feedback; dashboard tracking</td><td align="left" valign="top">Frequent asynchronous support and scalable tailored obesity prevention</td><td align="left" valign="top">Moderate; tailored logic described</td></tr><tr><td align="left" valign="top">Larizza et al [<xref ref-type="bibr" rid="ref22">22</xref>]</td><td align="left" valign="top">2023</td><td align="left" valign="top">Collects responses and provides practical advice through a virtual coach</td><td align="left" valign="top">V-care app (University of Pavia) with Google Dialogflow chatbot</td><td align="left" valign="top">Task-oriented conversational agent using Dialogflow natural language processing and predefined workflows</td><td align="left" valign="top">Profile, questionnaires, quizzes, daily/weekly behavior diary, BMI updates</td><td align="left" valign="top">Questionnaire administration; coaching; advice; engagement</td><td align="left" valign="top">Increase compliance and reduce dropout in pediatric obesity management</td><td align="left" valign="top">Good technical description of architecture; limited algorithmic detail beyond workflow</td></tr><tr><td align="left" valign="top">Moore et al [<xref ref-type="bibr" rid="ref23">23</xref>]</td><td align="left" valign="top">2024</td><td align="left" valign="top">Identifies physical activity barriers and delivers tailored relational support</td><td align="left" valign="top">Phyllis conversational agent (Sheffield Hallam University); Google Dialogflow and MindBehind (MindBehind Inc) engine</td><td align="left" valign="top">Natural language understanding for intent recognition and dialogue routing</td><td align="left" valign="top">Open-text user barrier input; conversation responses</td><td align="left" valign="top">Intent recognition; routing; tailored dialogue; persuasive coaching</td><td align="left" valign="top">On-demand personalized support to overcome PA barriers</td><td align="left" valign="top">Moderate; NLU<sup><xref ref-type="table-fn" rid="table4fn3">c</xref></sup> training and <italic>F</italic><sub>1</sub>-score reported</td></tr><tr><td align="left" valign="top">Oh et al [<xref ref-type="bibr" rid="ref24">24</xref>]</td><td align="left" valign="top">2022</td><td align="left" valign="top">Recognizes body movements and provides exergame feedback</td><td align="left" valign="top">Super Kids Adventure (Funrehab)</td><td align="left" valign="top">Computer vision and deep learning using a convolutional neural network (CNN)</td><td align="left" valign="top">Video/image-based body movement data</td><td align="left" valign="top">Gesture recognition; exercise scoring; real-time feedback</td><td align="left" valign="top">Low-cost motivational home exercise alternative</td><td align="left" valign="top">Basic model type reported (CNN), limited technical detail</td></tr><tr><td align="left" valign="top">Peuters et al [<xref ref-type="bibr" rid="ref25">25</xref>]</td><td align="left" valign="top">2024</td><td align="left" valign="top">Delivers automated chatbot support and behavior-change content</td><td align="left" valign="top">#LIFEGOALS mobile app chatbot</td><td align="left" valign="top">Scripted or predefined chatbot support; underlying algorithm not fully reported</td><td align="left" valign="top">Self-report survey data; Fitbit (Google LLC)/self-monitoring data; accelerometer data</td><td align="left" valign="top">Support messages; information delivery; self-regulation support</td><td align="left" valign="top">Engage adolescents in healthy lifestyle behavior change and mental health promotion</td><td align="left" valign="top">Limited</td></tr><tr><td align="left" valign="top">Stasinaki et al [<xref ref-type="bibr" rid="ref26">26</xref>]</td><td align="left" valign="top">2021</td><td align="left" valign="top">Delivers daily conversational coaching and challenges</td><td align="left" valign="top">PathMate2 (Pathmate Technologies AG) mobile app</td><td align="left" valign="top">Scripted or predefined conversational coaching and challenge-delivery logic; underlying algorithm not fully reported</td><td align="left" valign="top">Chat interactions; challenge completion; self-reported meal photos and exercises</td><td align="left" valign="top">Conversational coaching; reminders; challenge monitoring</td><td align="left" valign="top">Low-threshold obesity support with fewer clinic visits</td><td align="left" valign="top">Moderate; app functions described</td></tr><tr><td align="left" valign="top">Tan et al [<xref ref-type="bibr" rid="ref27">27</xref>]</td><td align="left" valign="top">2026</td><td align="left" valign="top">Provides personalized feedback for self-management</td><td align="left" valign="top">ProudMe Tech (ProudMe Technologies); GPT-4 (OpenAI) API</td><td align="left" valign="top">GPT-assisted chatbot using generative AI</td><td align="left" valign="top">Self-reported goals, behavior logs, reflections, interaction logs</td><td align="left" valign="top">Feedback generation; supportive prompting; text analysis for evaluation</td><td align="left" valign="top">Scalable, low-cost personalized behavioral counseling for students</td><td align="left" valign="top">Partial; app functions described but limited model detail</td></tr><tr><td align="left" valign="top">Zarkogianni et al [<xref ref-type="bibr" rid="ref29">29</xref>]</td><td align="left" valign="top">2023</td><td align="left" valign="top">Generates personalized messages and recommendations based on user profiles</td><td align="left" valign="top">ENDORSE (ENDORSE Consortium) platform</td><td align="left" valign="top">Machine learning&#x2013;based recommendation and personalization system, including genetic algorithm components</td><td align="left" valign="top">Tracker data; serious game interactions; clinical/nutrition data; user profile</td><td align="left" valign="top">Personalization; recommendation; risk/behavior profiling</td><td align="left" valign="top">Coordinated family-clinician ecosystem for personalized obesity management</td><td align="left" valign="top">Moderate; AI-based model described at high level</td></tr><tr><td align="left" valign="top">Kim et al [<xref ref-type="bibr" rid="ref20">20</xref>]</td><td align="left" valign="top">2025</td><td align="left" valign="top">Provides chatbot-supported health guidance and personalized service delivery</td><td align="left" valign="top">MUZZIM smart health service concept</td><td align="left" valign="top">Integrated chatbot-supported digital health ecosystem; specific technical approach not fully reported</td><td align="left" valign="top">Health information, wearable/lifelog data, user needs, app inputs</td><td align="left" valign="top">Guidance; personalization; integrated monitoring</td><td align="left" valign="top">Support sustainable adolescent health habits through school-family digital ecosystem</td><td align="left" valign="top">Conceptual only</td></tr><tr><td align="left" valign="top">Kang et al [<xref ref-type="bibr" rid="ref21">21</xref>]</td><td align="left" valign="top">2026</td><td align="left" valign="top">Examines the acceptability of a proposed chatbot for future lifestyle management support</td><td align="left" valign="top">No chatbot was deployed or named</td><td align="left" valign="top">Proposed generative AI chatbot concept; no live AI system evaluated</td><td align="left" valign="top">Survey responses on healthy lifestyle practices, chatbot awareness, and open-ended unmet healthy lifestyle needs</td><td align="left" valign="top">Conceptual health education, lifestyle guidance, interaction, and support for future survivorship care</td><td align="left" valign="top">Potential to provide tailored, interactive, real-time support for holistic survivorship healthy lifestyle management</td><td align="left" valign="top">Not applicable because no live AI system was tested</td></tr><tr><td align="left" valign="top">Willms and Liu [<xref ref-type="bibr" rid="ref28">28</xref>]</td><td align="left" valign="top">2024</td><td align="left" valign="top">Generates intervention content for a just-in-time adaptive intervention</td><td align="left" valign="top">ChatGPT-3 and Pathverse (Pathverse Ltd) no-code mobile app builder</td><td align="left" valign="top">Generative AI using a large language model for content development; predefined decision rules for intervention tailoring</td><td align="left" valign="top">Researcher prompts with theory, target behavior, and intervention structure</td><td align="left" valign="top">Content generation</td><td align="left" valign="top">Rapid, scalable creation of tailored mHealth<sup><xref ref-type="table-fn" rid="table4fn4">d</xref></sup>/JITAI<sup><xref ref-type="table-fn" rid="table4fn5">e</xref></sup> content</td><td align="left" valign="top">Prompting process described; acknowledged hallucination/privacy limits</td></tr></tbody></table><table-wrap-foot><fn id="table4fn1"><p><sup>a</sup>PA: physical activity.</p></fn><fn id="table4fn2"><p><sup>b</sup>ASD: autism spectrum disorder.</p></fn><fn id="table4fn3"><p><sup>c</sup>NLU: natural language understanding.</p></fn><fn id="table4fn4"><p><sup>d</sup>mHealth: mobile health.</p></fn><fn id="table4fn5"><p><sup>e</sup>JITAI: Just-in-Time Adaptive Intervention.</p></fn></table-wrap-foot></table-wrap><p>Across studies, the most common role of AI was to support personalization and automated interaction rather than diagnosis or prediction. Tailored feedback, adaptive support, or personalized recommendations were described in 10 studies [<xref ref-type="bibr" rid="ref17">17</xref>-<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref25">25</xref>-<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref29">29</xref>]. Chatbot-based or conversational coaching features were present in 8 studies [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref21">21</xref>-<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref25">25</xref>-<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref29">29</xref>], activity generation or exercise recommendation in 4 studies [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref29">29</xref>], and monitoring or self-management support in 6 studies [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref29">29</xref>].</p><p>Input data were most commonly participant- or caregiver-entered, including text prompts, questionnaires, goal selections, behavior logs, profile information, or interaction history. Six studies [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref27">27</xref>-<xref ref-type="bibr" rid="ref29">29</xref>] incorporated wearable, sensor, image, or other objectively tracked data as part of the AI-supported system. Technical reporting of AI methods was often limited. Seven studies [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref27">27</xref>-<xref ref-type="bibr" rid="ref30">30</xref>] provided only limited, conceptual, or partial descriptions of AI logic or architecture, whereas 6 [<xref ref-type="bibr" rid="ref17">17</xref>-<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref25">25</xref>] provided at least moderate detail about system workflow, personalization logic, or model type. One study [<xref ref-type="bibr" rid="ref21">21</xref>] did not evaluate a live AI system but instead assessed attitudes toward a proposed future chatbot.</p></sec><sec id="s3-6"><title>Theory, Implementation, and Outcome Findings</title><p>Theoretical frameworks were identified in most studies (<xref ref-type="table" rid="table5">Table 5</xref>), including Social Cognitive Theory [<xref ref-type="bibr" rid="ref19">19</xref>]; the capability, opportunity, motivation, and behavior (COM-B) model; the Theoretical Domains Framework [<xref ref-type="bibr" rid="ref23">23</xref>]; the Health Action Process Approach; the Elaboration Likelihood Model; Persuasive Systems Design [<xref ref-type="bibr" rid="ref25">25</xref>]; Self-Determination Theory [<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref29">29</xref>]; the Health Promotion Model; the Technology Acceptance Model [<xref ref-type="bibr" rid="ref21">21</xref>], and the Multi-Process Action Control (M-PAC) model [<xref ref-type="bibr" rid="ref28">28</xref>]. Other studies referenced broader approaches such as cognitive-behavioral principles, family-centered care, or user-centered design, whereas Aydemir [<xref ref-type="bibr" rid="ref17">17</xref>] and Oh et al [<xref ref-type="bibr" rid="ref24">24</xref>] did not report an explicit theoretical framework.</p><table-wrap id="t5" position="float"><label>Table 5.</label><caption><p>Theoretical foundations, implementation outcomes, and behavioral/health outcomes.</p></caption><table id="table5" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom" colspan="2">Study and year</td><td align="left" valign="bottom">Theoretical framework</td><td align="left" valign="bottom">Feasibility/acceptability/usability/engagement</td><td align="left" valign="bottom">Primary PA<sup><xref ref-type="table-fn" rid="table5fn1">a</xref></sup> outcomes</td><td align="left" valign="bottom">Secondary outcomes</td><td align="left" valign="bottom">Key findings/effect Size</td></tr></thead><tbody><tr><td align="left" valign="top" colspan="2">Aydemir (2025) [<xref ref-type="bibr" rid="ref17">17</xref>]</td><td align="left" valign="top">NR<sup><xref ref-type="table-fn" rid="table5fn2">b</xref></sup></td><td align="left" valign="top">High parent satisfaction; 92% participated in WhatsApp (Meta) discussions</td><td align="left" valign="top">Leisure Time Exercise Questionnaire (LTEQ)</td><td align="left" valign="top">Parent feasibility feedback</td><td align="left" valign="top">LTEQ increased from 6.69 to 34.00 in intervention versus 7.46-7.23 in control; interaction <italic>F</italic>=353.07; <italic>P</italic>&#x003C;.001; &#x03B7;p&#x00B2;=.936</td></tr><tr><td align="left" valign="top" colspan="2">de Arriba Mu&#x00F1;oz et al<break/>(2026) [<xref ref-type="bibr" rid="ref18">18</xref>]</td><td align="left" valign="top">Cognitive-behavioral principles</td><td align="left" valign="top">SUS<sup><xref ref-type="table-fn" rid="table5fn3">c</xref></sup> score 72; exploratory trends between higher engagement and better fat loss</td><td align="left" valign="top">Wearable-recorded PA/biometric metrics collected, but main reported outcomes were clinical obesity measures</td><td align="left" valign="top">BMI, weight, body fat %, muscle mass %, waist circumference, usability, and engagement</td><td align="left" valign="top">At Day 150: BMI &#x2013;4.51 kg/m&#x00B2;; weight &#x2013;11.42 kg; body fat &#x2013;5.63%; waist &#x2013;8.69 cm; muscle mass 4.47% (all <italic>P</italic>&#x003C;.001)</td></tr><tr><td align="left" valign="top" colspan="2">Emerson et al<break/>(2026) [<xref ref-type="bibr" rid="ref30">30</xref>]</td><td align="left" valign="top">Family-centered care- or user-centered adaptation</td><td align="left" valign="top">Qualitative evidence of interest and need; branching logic and family support emphasized</td><td align="left" valign="top">NR</td><td align="left" valign="top">Feasibility, acceptability, accessibility needs, and adaptation recommendations</td><td align="left" valign="top">No efficacy outcomes; key themes were ASD<sup><xref ref-type="table-fn" rid="table5fn4">d</xref></sup> variability, perceived value of mHealth<sup><xref ref-type="table-fn" rid="table5fn5">e</xref></sup>, family-centered care, and interdisciplinary support</td></tr><tr><td align="left" valign="top" colspan="2">Heerman et al<break/>(2024) [<xref ref-type="bibr" rid="ref19">19</xref>]</td><td align="left" valign="top">Social Cognitive Theory; health literacy-informed design</td><td align="left" valign="top">High retention: 86.3% primary outcome at 24 months</td><td align="left" valign="top">No direct PA primary outcome; PA support behaviors embedded in program</td><td align="left" valign="top">Weight-for-length trajectory; BMI <italic>z</italic> score; overweight/obesity prevalence</td><td align="left" valign="top">Weight-for-length at 24 mo was lower by &#x2013;0.33 kg/m (95% CI &#x2013;0.57 to &#x2013;0.09); BMI <italic>z</italic> score &#x2212;0.19; obesity 7.4% versus 12.7% (aRR<sup><xref ref-type="table-fn" rid="table5fn6">f</xref></sup> 0.56)</td></tr><tr><td align="left" valign="top" colspan="2">Larizza et al<break/>(2023) [<xref ref-type="bibr" rid="ref22">22</xref>]</td><td align="left" valign="top">Psychological/behavioral change theories; goal-based behavioral intervention</td><td align="left" valign="top">Overall friendliness 85%; perceived utility 100%; chatbot acceptable to 69%; all average scores &#x003E;3/5</td><td align="left" valign="top">No quantitative PA outcome reported in pilot</td><td align="left" valign="top">Usability, acceptability, friendliness, and utility</td><td align="left" valign="top">High usability and perceived utility; chatbot section scored lower than other features but remained &#x003E;3/5</td></tr><tr><td align="left" valign="top" colspan="2">Moore et al<break/>(2024) [<xref ref-type="bibr" rid="ref23">23</xref>]</td><td align="left" valign="top">COM-B<sup><xref ref-type="table-fn" rid="table5fn7">g</xref></sup>; Theoretical domains framework; behavior change techniques; theory of planned behavior for confidence module</td><td align="left" valign="top">61 conversations; positive UX<sup><xref ref-type="table-fn" rid="table5fn8">h</xref></sup>; 73% definite intention to use; <italic>F</italic><sub>1</sub>-score about 80%</td><td align="left" valign="top">Perceived confidence and motivation to engage in PA</td><td align="left" valign="top">Acceptability, usability, recommendation likelihood, and barrier coverage</td><td align="left" valign="top">Significant increase in self-reported confidence and motivation after interacting with Phyllis (Sheffield Hallam University); 73% would use future version</td></tr><tr><td align="left" valign="top" colspan="2">Oh et al<break/>(2022) [<xref ref-type="bibr" rid="ref24">24</xref>]</td><td align="left" valign="top">NR</td><td align="left" valign="top">Postquestionnaire on motivation, fun, perceived exercise effectiveness</td><td align="left" valign="top">Calorie expenditure; VO<sub>2</sub>max<sup><xref ref-type="table-fn" rid="table5fn9">i</xref></sup>; 6MWT<sup><xref ref-type="table-fn" rid="table5fn10">j</xref></sup>; RPE<sup><xref ref-type="table-fn" rid="table5fn11">k</xref></sup>; BMI</td><td align="left" valign="top">Motivation, fun, and perceived exercise effectiveness</td><td align="left" valign="top">SUKIA (Funrehab) showed superior calorie consumption, VO<italic><sub>2</sub></italic>max, and RPE versus Nintendo Switch (Nintendo Co, Ltd); authors report better cardiopulmonary function and energy expenditure</td></tr><tr><td align="left" valign="top" colspan="2">Peuters et al<break/>(2024) [<xref ref-type="bibr" rid="ref25">25</xref>]</td><td align="left" valign="top">Health action process approach; elaboration likelihood model; persuasive systems design</td><td align="left" valign="top">High nonusage attrition: 18% never used app; 30% stopped by week 2; interviews highlighted rewards and self-regulation as helpful</td><td align="left" valign="top">PA (ENMO<sup><xref ref-type="table-fn" rid="table5fn12">l</xref></sup>/MVPA<sup><xref ref-type="table-fn" rid="table5fn13">m</xref></sup>) and sedentary behavior from accelerometers</td><td align="left" valign="top">HRQoL<sup><xref ref-type="table-fn" rid="table5fn14">n</xref></sup>, mood, peer support, sleep quality, sleep routine, and breakfast</td><td align="left" valign="top">Beneficial effects for PA (<italic>&#x03C7;</italic>&#x00B2;=4.36; <italic>P</italic>=.04), sedentary behavior (<italic>&#x03C7;</italic>&#x00B2;=6.44; <italic>P</italic>=.01), sleep quality (<italic>&#x03C7;</italic>&#x00B2;=6.11; <italic>P</italic>=.01), and mood (<italic>P</italic>=.02); effects moderated by COVID restrictions</td></tr><tr><td align="left" valign="top" colspan="2">Stasinaki et al<break/>(2021) [<xref ref-type="bibr" rid="ref26">26</xref>]</td><td align="left" valign="top">Behavior change techniques; obesity counseling framework (no single explicit theory emphasized)</td><td align="left" valign="top">Average daily app usage 71.5%; no side effects observed</td><td align="left" valign="top">Physical capacities (strength, agility, and endurance) via modified Dordel-Koch test</td><td align="left" valign="top">BMI-SDS<sup><xref ref-type="table-fn" rid="table5fn15">o</xref></sup>, fat mass, muscle mass, waist-to-height ratio, BP<sup><xref ref-type="table-fn" rid="table5fn16">p</xref></sup>, pulse, and stress markers</td><td align="left" valign="top">BMI-SDS decreased significantly in controls at 5.5 months, not in PathMate2 (PathMate Technologies GmbH); both groups improved muscle mass, strength, and agility by 12 months; PathMate2 reduced fat mass at T1/T2</td></tr><tr><td align="left" valign="top" colspan="2">Tan et al<break/>(2026) [<xref ref-type="bibr" rid="ref27">27</xref>]</td><td align="left" valign="top">Self-Determination Theory; Self-Regulation Theory</td><td align="left" valign="top">Mean 8.9 behavior entries, 30 reflections, 33.5 AI feedback messages; 63.8% of daily goals achieved</td><td align="left" valign="top">Self-reported PA hours</td><td align="left" valign="top">Screen time, fruit/vegetable intake, sleep, engagement, and sentiment</td><td align="left" valign="top">PA did not significantly change (2.5-2.4 h/day; <italic>P</italic>=.20); screen time decreased by 0.93 h/day (<italic>P</italic>&#x003C;.001); fruit/veg intake decreased by 0.50 servings (<italic>P</italic>=.02); sleep unchanged</td></tr><tr><td align="left" valign="top" colspan="2">Zarkogianni et al<break/>(2023) [<xref ref-type="bibr" rid="ref29">29</xref>]</td><td align="left" valign="top">Self-Determination Theory</td><td align="left" valign="top">Adherence tracked by usage frequency; activity tracker use correlated with BMI improvement</td><td align="left" valign="top">Activity tracker usage / PA patterns (minutes of activity; steps/day)</td><td align="left" valign="top">BMI <italic>z</italic> score, diet quality, screen time, sleep duration, and usability/adherence</td><td align="left" valign="top">Mean BMI <italic>z</italic> score reduction &#x2013;0.21 (SD 0.26); <italic>P</italic>&#x003C;.001; tracker usage correlated with BMI <italic>z</italic> score improvement (<italic>r</italic>=&#x2212;0.355<italic>; P</italic>=.02)</td></tr><tr><td align="left" valign="top" colspan="2">Kim et al<break/>(2025) [<xref ref-type="bibr" rid="ref20">20</xref>]</td><td align="left" valign="top">MASUN<sup><xref ref-type="table-fn" rid="table5fn17">q</xref></sup> framework/user-centered design methodology</td><td align="left" valign="top">Students/parents prioritized PA and sleep tracking; reward systems rated promising; teachers rated effectiveness/usefulness/usability highly</td><td align="left" valign="top">NR</td><td align="left" valign="top">User needs, usability ratings, and preferred features</td><td align="left" valign="top">No efficacy outcomes; stakeholders favored PA measurement, rewards, and integrated monitoring across student-parent-teacher interfaces</td></tr><tr><td align="left" valign="top" colspan="2">Kang et al<break/>(2026) [<xref ref-type="bibr" rid="ref21">21</xref>]</td><td align="left" valign="top">Health Promotion Model and Technology Acceptance Model</td><td align="left" valign="top">Positive perceptions of chatbot use in both groups; mean A-uC<sup><xref ref-type="table-fn" rid="table5fn18">r</xref></sup> scores were above 4/5 overall, with parents showing higher intention to use</td><td align="left" valign="top">No intervention PA outcome; PA was one healthy lifestyle subdomain and a commonly reported unmet need</td><td align="left" valign="top">Overall healthy lifestyle score and subdomains; awareness of chatbot use (perceived usefulness/ease, value, empathy, reliability, professionalism, intention to use); topic-modeled unmet needs</td><td align="left" valign="top">No significant group differences in overall healthy lifestyle score (CACSs<sup><xref ref-type="table-fn" rid="table5fn19">s</xref></sup> mean 3.16, SD 0.80 vs parents mean 3.18, SD 0.36; <italic>P</italic>=.74) or PA subscale (mean 2.55, SD 0.89 vs mean 2.53, SD 0.81, <italic>P</italic>=.91). Parents had higher intention to use chatbots (mean 4.21, SD 0.68 vs mean 3.94; SD 0.90; <italic>P</italic>=.03). Common unmet areas were exercise, healthy diet, and regular lifestyle.</td></tr><tr><td align="left" valign="top" colspan="2">Willms and Liu<break/>(2024) [<xref ref-type="bibr" rid="ref28">28</xref>]</td><td align="left" valign="top">Multi-Process Action Control (M-PAC)</td><td align="left" valign="top">Researchers found ChatGPT acceptable and easy to use for producing 13 lessons</td><td align="left" valign="top">NR</td><td align="left" valign="top">Feasibility, acceptability, and ease of use of AI-generated content process</td><td align="left" valign="top">ChatGPT (OpenAI) was judged acceptable and easy to use for creating 13 PA JITAI<sup><xref ref-type="table-fn" rid="table5fn20">t</xref></sup> lessons, but expert review remained essential due to the risk of inaccurate references/content</td></tr></tbody></table><table-wrap-foot><fn id="table5fn1"><p><sup>a</sup>PA: physical activity.</p></fn><fn id="table5fn2"><p><sup>b</sup>NR: Not Reported</p></fn><fn id="table5fn3"><p><sup>c</sup>SUS: system usability scale. </p></fn><fn id="table5fn4"><p><sup>d</sup>ASD: autism spectrum disorder.</p></fn><fn id="table5fn5"><p><sup>e</sup>mHealth: mobile health.</p></fn><fn id="table5fn6"><p><sup>f</sup>aRR: adjusted risk ratio.</p></fn><fn id="table5fn7"><p><sup>g</sup>COM-B: capability, opportunity, motivation, and behavior.</p></fn><fn id="table5fn8"><p><sup>h</sup>UX: user experience.</p></fn><fn id="table5fn9"><p><sup>i</sup>VO&#x2082;max: maximal oxygen uptake.</p></fn><fn id="table5fn10"><p><sup>j</sup>6MWT: 6-minute walk test.</p></fn><fn id="table5fn11"><p><sup>k</sup>RPE: rating of perceived exertion.</p></fn><fn id="table5fn12"><p><sup>l</sup>ENMO: Euclidean norm minus one.</p></fn><fn id="table5fn13"><p><sup>m</sup>MVPA: moderate to vigorous physical activity.</p></fn><fn id="table5fn14"><p><sup>n</sup>HRQoL: Health-related quality of life.</p></fn><fn id="table5fn15"><p><sup>o</sup>BMI-SDS: body mass index standard deviation score.</p></fn><fn id="table5fn16"><p><sup>p</sup>BP: blood pressure.</p></fn><fn id="table5fn17"><p><sup>q</sup>MASUN: Method of App Selection based on User Needs.</p></fn><fn id="table5fn18"><p><sup>r</sup>A-uC: Awareness of the Use of Chatbots.</p></fn><fn id="table5fn19"><p><sup>s</sup>CACS: childhood or adolescent cancer survivor.</p></fn><fn id="table5fn20"><p><sup>t</sup>JITAI: Just-in-Time Adaptive Intervention.</p></fn></table-wrap-foot></table-wrap><p>Outcome assessment approaches varied across studies (<xref ref-type="table" rid="table5">Table 5</xref>). Six studies [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref27">27</xref>,<xref ref-type="bibr" rid="ref29">29</xref>] included an objective or performance-based PA-related measure, such as accelerometer-assessed activity, Fitbit-derived metrics, step counts, calorie expenditure, physical fitness testing, or device-recorded movement patterns. Four studies [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref26">26</xref>] relied primarily on self-report or parent-report PA-related measures, including exercise questionnaires, activity hours, or perceived confidence and motivation for PA. The remaining 4 studies [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref30">30</xref>] did not directly assess intervention-related PA outcomes.</p><p>The studies frequently examined outcomes beyond PA alone. Anthropometric or weight-related outcomes, including BMI, BMI <italic>z</italic> score, body fat, waist circumference, or obesity-related indicators, were reported in 6 studies [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref29">29</xref>]. Diet- or nutrition-related outcomes were reported in 4 studies [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref29">29</xref>], screen time or sedentary behavior in 3 studies [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref27">27</xref>], and sleep-related outcomes in 3 studies [<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref25">25</xref>]. Psychosocial, motivational, quality-of-life, and usability-related outcomes were also commonly reported, suggesting that many AI-supported family-based interventions were conceptualized as broader healthy lifestyle or obesity-management programs rather than narrowly focused PA interventions.</p><p>Among the 8 studies that reported direct PA-, exercise-, movement-, or fitness-related outcomes, 4 [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref23">23</xref>-<xref ref-type="bibr" rid="ref25">25</xref>] reported significant improvements in PA participation, exercise performance, movement-related behavior, or fitness-related indicators. Two studies [<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref27">27</xref>] reported little or no statistically significant improvement in PA despite favorable findings for engagement or other health outcomes. One study [<xref ref-type="bibr" rid="ref18">18</xref>] collected wearable-based PA data but reported stronger clinical obesity-related effects than PA-specific effects, and one additional study [<xref ref-type="bibr" rid="ref19">19</xref>] described PA-related findings as part of a broader multibehavior framework without demonstrating a clearly significant PA effect.</p><p>All 14 original studies reported at least one feasibility-, acceptability-, usability-, or engagement-related outcome (<xref ref-type="table" rid="table5">Table 5</xref>). Five studies [<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref21">21</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref28">28</xref>,<xref ref-type="bibr" rid="ref30">30</xref>] were primarily qualitative, developmental, survey-based, or case-based in design and therefore emphasized user preferences, accessibility needs, perceived usefulness, desired features, implementation barriers, or design priorities rather than behavioral efficacy. These studies generally reported favorable perceptions of AI-supported tools, particularly when interventions were viewed as personalized, interactive, and supportive of family routines or youth autonomy.</p><p>Among the intervention-oriented studies, quantitative implementation indicators were commonly reported. Examples included high parent satisfaction and 92% participation in WhatsApp discussions in one parent-mediated ChatGPT study [<xref ref-type="bibr" rid="ref17">17</xref>]; a System Usability Scale score of 72 in one obesity-management intervention [<xref ref-type="bibr" rid="ref18">18</xref>]; 86.3% retention at 24 months in the large primary care trial; 85% friendliness, 100% perceived utility, and 69% acceptability in one pediatric obesity app pilot [<xref ref-type="bibr" rid="ref22">22</xref>]; 61 total chatbot conversations and 73% definite intention to use in one conversational-agent co-design study [<xref ref-type="bibr" rid="ref23">23</xref>]; average daily app usage of 71.5% in one obesity management trial [<xref ref-type="bibr" rid="ref26">26</xref>]; and a mean of 8.9 (SD 7.6) behavior entries, 30 reflections, and 33.5 AI feedback interactions in one school-based chatbot study [<xref ref-type="bibr" rid="ref27">27</xref>]. One quasi-randomized trial reported substantial nonuse attrition, with 18% of participants never using the app and 30% stopping use by week 2 [<xref ref-type="bibr" rid="ref25">25</xref>].</p></sec></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><sec id="s4-1"><title>Principal Findings</title><p>This scoping review explored the emerging evidence on AI and chatbot-supported interventions targeting PA and obesity-related lifestyle behaviors among children and adolescents, with attention to family involvement. Across the 14 studies included, the evidence indicates that AI-supported interventions are being used in increasingly diverse ways to support PA, obesity management, and related health behaviors in pediatric populations, but the literature remains varied in terms of intervention design, AI capabilities, family involvement, and outcome measurement.</p></sec><sec id="s4-2"><title>Complex AI Features Across Studies</title><p>Across the included studies, AI features span a continuum of complexity, from rule-based scripted chatbots and automated tailoring systems (eg, structured coaching or tailored text messaging) to hybrid systems that incorporated limited natural language understanding or personalization. AI was most commonly used to support personalization, user interaction, and ongoing behavioral support, rather than for diagnostic, predictive, or decision-making purposes. Many studies provided only high-level or conceptual descriptions of system functionality, with limited detail on model architecture, training data, validation procedures, or performance across subgroups. This lack of transparency makes it difficult to assess reproducibility, evaluate potential bias, or determine whether AI-driven personalization meaningfully contributes to outcomes beyond standard digital tailoring approaches. These gaps are particularly important given the increasing integration of more complex AI systems, which introduce additional concerns related to accuracy, safety, and algorithmic bias. Future research should adopt AI-specific reporting standards and explicitly document how AI outputs are validated, monitored, and updated over time across diverse populations.</p></sec><sec id="s4-3"><title>Delivery Platforms and Intervention Components</title><p>Regarding the delivery platform and intervention components, most interventions embed common behavior change functions, including self-monitoring, goal setting, education, feedback, and rewards, within various platforms. These platforms range from low-burden text messaging and web dashboards to multiapp family&#x2013;clinician ecosystems, wearable-linked systems, higher-complexity immersive environments, and sensor-rich exercise apps. Engagement strategies also include gamification, relational dialogue, narrative content, and school- or family-embedded routines. Within this structure, AI primarily serves as a delivery and personalization mechanism that shaped how these components were implemented. AI enabled more dynamic forms of support, such as routine coaches, on-demand assistants, and interactive educational or motivational agents [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref28">28</xref>]. In this sense, AI modifies the timing, intensity, and responsiveness of intervention delivery rather than fundamentally changing its core behavioral content.</p></sec><sec id="s4-4"><title>Extent and Operationalization of Family Engagement</title><p>A central contribution to this review is the characterization of family involvement, which was important but inconsistently operationalized. In some studies, parents were critical to implementation, such as delivering activities at home, receiving caregiver education, or interacting with the digital system directly [<xref ref-type="bibr" rid="ref17">17</xref>-<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref29">29</xref>]. In others, youth were the primary users and family influence was acknowledged but not fully integrated into the intervention structure [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref27">27</xref>]. This variability suggests that the field has not yet converged on a clear definition of what constitutes a &#x201C;family-based&#x201D; AI intervention. Importantly, most studies do not measure family engagement systematically enough to test whether caregiver involvement mediates or moderates intervention effects. More precise conceptualization of whether caregivers are intended as co-users, facilitators, role models, or targets of behavior change may improve both intervention design and interpretation of outcomes.</p></sec><sec id="s4-5"><title>Limited Cultural Tailoring and Bilingual Intervention</title><p>With respect to cultural tailoring and bilingual delivery, evidence remains limited. One large randomized clinical trial embedded bilingual delivery (English/Spanish) and cultural appropriateness processes in a racially and ethnically diverse population [<xref ref-type="bibr" rid="ref19">19</xref>]. Although all studies could be situated within identifiable linguistic or contextual settings, specific cultural adaptation was rare, and the evidence base was entirely in middle- and high-income countries. This limits the transferability of current findings to lower-resource contexts and to culturally diverse family populations whose routines, values, digital access, and barriers to health behavior change may differ substantially. The lack of consistent reporting on cultural tailoring, bilingual adaptation, and structural access issues also limits understanding of how well current interventions align with the realities of underserved families. These limitations introduce broader concerns in digital health that technologies may inadvertently reinforce inequities if they are developed primarily in well-resourced settings without sufficient adaptation for different social and cultural contexts [<xref ref-type="bibr" rid="ref31">31</xref>].</p></sec><sec id="s4-6"><title>Exploratory Feasibility and Efficacy Findings</title><p>Consistent with the aims of this review, PA emerged as the most prominent target behavior, either as a primary intervention focus or as part of broader multibehavior lifestyle and obesity-management programs. Several studies focused directly on PA promotion, home exercise, or movement-related confidence and performance [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref24">24</xref>,<xref ref-type="bibr" rid="ref27">27</xref>], whereas others addressed PA within broader interventions targeting obesity prevention, rehabilitation, or healthy lifestyle routines [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref29">29</xref>]. This pattern likely reflects both the importance of PA in pediatric health promotion and the broader reality that children&#x2019;s movement behaviors are closely associated with diet, sleep, sedentary behavior, and family routines. Rather than treating PA as an isolated outcome, many of the included studies positioned it within a more comprehensive family lifestyle framework.</p><p>The reviewed studies also indicate that AI-supported interventions were generally more consistent in demonstrating feasibility, acceptability, and engagement than in behavioral efficacy. These findings align with previous youth-focused syntheses emphasizing that chatbots and AI-supported tools are often perceived as appealing and acceptable when they are interactive, personalized, and low burden [<xref ref-type="bibr" rid="ref12">12</xref>]. However, the current review also found that favorable usability does not necessarily translate into sustained engagement or robust changes in PA participation, exercise performance, calorie expenditure, cardiopulmonary function, or confidence and motivation for PA [<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref23">23</xref>-<xref ref-type="bibr" rid="ref25">25</xref>], and some broader obesity-management or prevention interventions also showed favorable changes in clinical or anthropometric outcomes [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref19">19</xref>,<xref ref-type="bibr" rid="ref29">29</xref>]. At the same time, findings were not uniform across studies. Tan et al [<xref ref-type="bibr" rid="ref27">27</xref>] did not detect significant changes in PA, and Stasinaki et al [<xref ref-type="bibr" rid="ref26">26</xref>] did not show clear superiority of the conversational-agent intervention over the comparison condition for BMI-SD score (BMI-SDS). Moreover, many included studies were feasibility, pilot, or developmental studies rather than adequately powered effectiveness trials. These findings suggest that while AI-supported interventions show promise, the current evidence remains stronger for feasibility and acceptability than for clinically meaningful and sustained improvements in PA and related outcomes.</p></sec><sec id="s4-7"><title>Implications for Practice and Research</title><p>This review highlights several implications for intervention design, implementation, and future research. In practice, AI-supported family interventions may be most useful when integrated into broader family-based, school-based, or clinical programs rather than positioned as isolated tools. Their strengths appear to lie in delivering tailored education, self-monitoring support, reminders, coaching, and feedback in ways that are flexible, scalable, and responsive to daily family routines. However, the findings also indicate that intervention success likely depends on more than the presence of AI alone. Additional attention to developmental appropriateness, caregiver roles, response quality, burden of use, and contextual relevance will be essential to sustaining engagement and producing meaningful behavior change.</p><p>Future research and program development should prioritize family-centered co-design, more rigorous comparative and longitudinal study designs, and greater consistency and transparency in reporting AI features, personalization logic, and behavior change techniques. More culturally and linguistically responsive adaptation is also needed, particularly for diverse and underserved family populations. Additional work should examine implementation outcomes such as reach, adoption, maintenance, scalability, and cost, alongside behavioral and clinical outcomes. Emerging approaches such as generative AI, wearable-integrated personalization, and adaptive feedback systems may offer added value, but their safety, accuracy, transparency, and practical benefit require more careful evaluation in pediatric settings. Continued interdisciplinary collaboration will play an important role in ensuring that AI-supported family interventions are not only innovative but also ethical, accessible, and equitable.</p></sec><sec id="s4-8"><title>Limitations</title><p>Several limitations should be acknowledged. First, the number of included studies was small, and the evidence base was highly heterogeneous. Further, the included studies varied widely in population, intervention modality, duration, AI sophistication, and measured outcomes, which limits comparability. In addition, many studies were pilots, feasibility studies, or usability-focused investigations rather than adequately powered trials. Further, reporting of demographic, contextual, and technical AI details was often incomplete, making it difficult to assess generalizability or identify active intervention ingredients. The search was limited to English-language publications; therefore, relevant studies published in other languages may not have been captured, which may have introduced selection bias. Further, the search was limited to peer-reviewed publications indexed in the selected databases and did not include a formal gray-literature search or supplementary citation tracking. Therefore, relevant evidence reported in theses, reports, conference materials, policy documents, unpublished sources, or publications not indexed in the selected databases may not have been captured. A formal critical appraisal or methodological quality assessment was not conducted; therefore, the methodological rigor of the included studies was not evaluated.</p></sec><sec id="s4-9"><title>Conclusion</title><p>In conclusion, this scoping review found that AI and chatbot-supported interventions for pediatric PA and obesity-related lifestyle behaviors are a rapidly emerging but still early-stage field. The existing literature suggests that these interventions are generally feasible, acceptable, and promising as scalable tools for supporting healthy behavior change among children and families. However, evidence for effectiveness, particularly for PA outcomes, remains mixed and limited by methodological heterogeneity, short follow-up, and inconsistent outcomes. The review also highlights important gaps in family-based design, cultural tailoring, equity, and evaluation of advanced AI capabilities. Future research should prioritize rigorous trials, clearer conceptualization of family engagement, objective outcome measurement, and culturally responsive development to ensure that AI-supported interventions are not only innovative but also effective, equitable, and meaningful for diverse families.</p></sec></sec></body><back><ack><p>Declaration of Generative AI and AI-Assisted Technologies in the Manuscript Preparation Process.</p><p>During the preparation of this manuscript, the authors used ChatGPT (OpenAI) for proofreading, language editing, and reformatting of author-written text. Generative AI was not used to generate original manuscript content or to conduct the literature search, study screening, data extraction, analysis, or interpretation. The authors reviewed and approved all revisions and take full responsibility for the content of the manuscript.</p></ack><notes><sec><title>Funding</title><p>This work was supported by the University of Central Florida (UCF) Center for Behavioral Health Research and Training (CBHRT) Seed Grant, 2025&#x2013;2026 cycle. The funding source had no role in the study design; collection, analysis, or interpretation of data; writing of the manuscript; or decision to submit the manuscript for publication.</p></sec><sec><title>Data Availability</title><p>The data extracted for this scoping review are available from the corresponding author upon reasonable request.</p></sec></notes><fn-group><fn fn-type="con"><p>Conceptualization: QJ, XSC</p><p>Data curation: DP, SA</p><p>Formal analysis: QJ</p><p>Funding acquisition: QJ</p><p>Investigation: DP, SA</p><p>Methodology: QJ, XSC</p><p>Project administration: QJ</p><p>Supervision: QJ, KB</p><p>Writing &#x2013; original draft: QJ, XSC</p><p>Writing &#x2013; review &#x0026; editing: QJ, XSC, DP, SA, KB</p><p>All authors read and approved the final manuscript.</p></fn><fn fn-type="conflict"><p>None declared.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">BMI-SDS</term><def><p>BMI-SD score</p></def></def-item><def-item><term id="abb2">COM-B</term><def><p>capability, opportunity, motivation, and behavior</p></def></def-item><def-item><term id="abb3">M-PAC</term><def><p>Multi-Process Action Control</p></def></def-item><def-item><term id="abb4">PA</term><def><p>physical activity</p></def></def-item><def-item><term id="abb5">PICOS</term><def><p>population, intervention, comparator, outcomes, and study design</p></def></def-item><def-item><term id="abb6">PRISMA</term><def><p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</p></def></def-item><def-item><term id="abb7">PRISMA-ScR</term><def><p>Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews</p></def></def-item><def-item><term id="abb8">WHO</term><def><p>World Health Organization</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group 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