<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="review-article"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Pediatr Parent</journal-id><journal-id journal-id-type="publisher-id">pediatrics</journal-id><journal-id journal-id-type="index">30</journal-id><journal-title>JMIR Pediatrics and Parenting</journal-title><abbrev-journal-title>JMIR Pediatr Parent</abbrev-journal-title><issn pub-type="epub">2561-6722</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v9i1e83228</article-id><article-id pub-id-type="doi">10.2196/83228</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Screen Time, Child Depression, and Anxiety During the COVID-19 Pandemic: Systematic Review and Meta-Analysis</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Yoshizawa</surname><given-names>Marissa</given-names></name><degrees>PsyD, MSW</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Rafeedie</surname><given-names>Jennifer</given-names></name><degrees>PsyD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Tang</surname><given-names>Jasmyn J</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Lei</surname><given-names>Bryan T</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Durazo-Arvizu</surname><given-names>Ramon</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Azucar</surname><given-names>Danny</given-names></name><degrees>PhD, MPH</degrees><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Hudson</surname><given-names>Sharon</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Rao</surname><given-names>Sheela</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Imagawa</surname><given-names>Karen Kay</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Deavenport-Saman</surname><given-names>Alexis</given-names></name><degrees>DrPH, MPH</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib></contrib-group><aff id="aff1"><institution>Department of Pediatrics, Children's Hospital Los Angeles</institution><addr-line>4650 Sunset Blvd MS53</addr-line><addr-line>Los Angeles</addr-line><addr-line>CA</addr-line><country>United States</country></aff><aff id="aff2"><institution>Department of Pediatrics, Keck School of Medicine, University of Southern California</institution><addr-line>Los Angeles</addr-line><addr-line>CA</addr-line><country>United States</country></aff><aff id="aff3"><institution>Division of General Internal Medicine and Health Services, David Geffen School of Medicine, University of California Los Angeles</institution><addr-line>Los Angeles</addr-line><addr-line>CA</addr-line><country>United States</country></aff><aff id="aff4"><institution>Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles</institution><addr-line>Los Angeles</addr-line><addr-line>CA</addr-line><country>United States</country></aff><aff id="aff5"><institution>AltaMed Institute for Health Equity</institution><addr-line>Los Angeles</addr-line><addr-line>CA</addr-line><country>United States</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Badawy</surname><given-names>Sherif</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Pratomo</surname><given-names>Hadi</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Wu</surname><given-names>Yin</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Marissa Yoshizawa, PsyD, MSW, Department of Pediatrics, Children's Hospital Los Angeles, 4650 Sunset Blvd MS53, Los Angeles, CA, 90027, United States, 1 323 361 5734, 1 323 361 1383; <email>myoshizawa@chla.usc.edu</email></corresp></author-notes><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>1</day><month>4</month><year>2026</year></pub-date><volume>9</volume><elocation-id>e83228</elocation-id><history><date date-type="received"><day>05</day><month>09</month><year>2025</year></date><date date-type="rev-recd"><day>12</day><month>01</month><year>2026</year></date><date date-type="accepted"><day>25</day><month>01</month><year>2026</year></date></history><copyright-statement>&#x00A9; Marissa Yoshizawa, Jennifer Rafeedie, Jasmyn J Tang, Bryan T Lei, Ramon Durazo-Arvizu, Danny Azucar, Sharon Hudson, Sheela Rao, Karen Kay Imagawa, Alexis Deavenport-Saman. Originally published in JMIR Pediatrics and Parenting (<ext-link ext-link-type="uri" xlink:href="https://pediatrics.jmir.org">https://pediatrics.jmir.org</ext-link>), 1.4.2026. </copyright-statement><copyright-year>2026</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Pediatrics and Parenting, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://pediatrics.jmir.org">https://pediatrics.jmir.org</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://pediatrics.jmir.org/2026/1/e83228"/><abstract><sec><title>Background</title><p>In response to the COVID-19 pandemic, governments around the world enforced stay-at-home orders and social distancing guidelines that amplified the use of screen time among pediatric populations. Excessive screen time may negatively impact mental health by increasing depression and anxiety.</p></sec><sec><title>Objective</title><p>The first aim was to conduct a systematic review of articles examining screen time and mental health outcomes among children and adolescents during the COVID-19 pandemic from 2020 to 2023. The second aim was to determine the combined effect sizes for the associations of screen time and depression and/or anxiety among children and adolescents during the COVID-19 pandemic from 2020 to 2023 and whether gender or age influenced outcomes.</p></sec><sec sec-type="methods"><title>Methods</title><p>Bibliographic databases were searched including MEDLINE (Ovid), Embase (Elsevier), Cochrane Library (Wiley), CINAHL Complete (EBSCO), and PsycINFO (EBSCO). There were a total of 6462 nonduplicate studies that were screened. Study inclusion criteria included children ages 0 to &#x003C;18 years, the effects of screen time on children during the COVID-19 pandemic, screen time and depression and/or anxiety, articles written in English, and articles, including quantitative and qualitative studies, published between 2020 and 2023. A total of 452 articles underwent full-text review with 23 articles meeting criteria for final article extraction.</p></sec><sec sec-type="results"><title>Results</title><p>A total of 23 studies totaling 29,581 children and adolescents were included in the study. Results showed that most studies reported a positive association between screen time and depression and/or anxiety (<italic>r</italic>=0.175, 95% CI 0.124-0.226, <italic>P</italic>&#x003C;.001 and <italic>r</italic>=0.157, 95% CI 0.0994-0.214, <italic>P</italic>&#x003C;.001, respectively) during COVID-19. Meta-regression revealed that screen time measured in problematic use of electronic devices had a 0.15 higher correlation with anxiety compared to screen time measured in duration of electronic device use.</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>During the COVID-19 pandemic, children and adolescents with higher levels of screen time had increased depression and/or anxiety. Findings suggest the need for ongoing parent, professional, and self-monitoring of youth screen behaviors and habits as well as activities that promote social connectedness during global or national health emergencies.</p></sec></abstract><kwd-group><kwd>screen time</kwd><kwd>anxiety</kwd><kwd>depression</kwd><kwd>COVID-19 pandemic</kwd><kwd>children</kwd><kwd>adolescents</kwd><kwd>mental health</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>The global COVID-19 pandemic impacted children&#x2019;s screen time. As numerous restrictions were put on children and adolescents during COVID-19, regular screen usage increased due to the closure of regular outdoor activities and increase in online learning. A meta-analysis of over 29,000 children showed a 52% increase in screen time, particularly for those aged 12&#x2010;18 years [<xref ref-type="bibr" rid="ref1">1</xref>]. Excessive screen time increased, with adolescents reported to have almost 6 hours per day of screen use, mainly spent on watching shows, movies, and playing games [<xref ref-type="bibr" rid="ref2">2</xref>]. One-third of adolescents aged 13&#x2010;17 years reported using social media &#x201C;almost constantly&#x201D; [<xref ref-type="bibr" rid="ref3">3</xref>]. Children at 9.5 years of age who were surveyed during the COVID-19 pandemic reported an average increase in recreational screen time of 11 hours per week compared to the 1 hour per week increase reported in prepandemic surveys conducted at ages 5 and 8 years [<xref ref-type="bibr" rid="ref4">4</xref>].</p><p>The COVID-19 pandemic also exacerbated the preexisting mental health challenges of children and adolescents [<xref ref-type="bibr" rid="ref5">5</xref>]. A meta-analysis covering over 80,000 youths globally found that the prevalence of anxiety and depression doubled during the COVID-19 pandemic to 20%&#x2010;25% [<xref ref-type="bibr" rid="ref6">6</xref>]. In the United States, emergency visits for children due to mental health problems rose drastically by 31%&#x2010;50% since the beginning of the pandemic [<xref ref-type="bibr" rid="ref7">7</xref>]. Globally, depression and posttraumatic stress disorder were significantly more prevalent among children aged 7 to 15 years [<xref ref-type="bibr" rid="ref8">8</xref>] due to the separation from classmates and friends. Overall, distancing measures during the pandemic were harmful to adolescent mental health [<xref ref-type="bibr" rid="ref9">9</xref>].</p><p>The opportunity for excessive screen use during the COVID-19 pandemic also impacted mental health outcomes among children and adolescents. Social media and media addiction were associated with ill-being among adolescents [<xref ref-type="bibr" rid="ref9">9</xref>]. The US Surgeon General released a report [<xref ref-type="bibr" rid="ref10">10</xref>] indicating potential risks of social media use on the mental health of children and adolescents and called for more evidence. During the pandemic, a greater duration of screen time (such as television viewing [<xref ref-type="bibr" rid="ref10">10</xref>] or digital media time [<xref ref-type="bibr" rid="ref10">10</xref>], including social media use [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref12">12</xref>]) was associated with higher levels of depression and anxiety [<xref ref-type="bibr" rid="ref12">12</xref>]. The associations between screen time and poor mental health outcomes have been found in individual studies; however, to our knowledge, there have not been meta-analyses of screen time using standardized or validated measures of depression and anxiety during the pandemic.</p><p>Thus, this review aims to fill this gap by examining the mental health effects of screen time in children and adolescents throughout the COVID-19 pandemic. First, the purpose was to conduct a systematic review of articles examining screen time and depression and anxiety among children and adolescents during the COVID-19 pandemic from 2020 to 2023. Second, the purpose was to determine the combined effect size for the association of screen time and depression and anxiety among children and adolescents during the COVID-19 pandemic from 2020 to 2023. We additionally explored the influence of gender and age on the relationship between screen time and mental health outcomes.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Eligibility Criteria</title><p>Studies identified through database searches were screened for the following inclusion criteria: (1) children ages 0 to &#x003C;18 years, (2) examination of the effects of screen time on children during the COVID-19 pandemic (eg, video games, smartphone use, or computer use), (3) examination of screen time and anxiety and/or depression, (4) articles were written in English, and (5) studies, including quantitative and qualitative studies, published between 2020 and 2023. Studies were excluded if they did not describe the effects of screen time on children during the COVID-19 pandemic (eg, provider-led and provider-care interventions; telehealth) or did not meet the inclusion criteria listed above.</p></sec><sec id="s2-2"><title>Information Sources and Search Strategy</title><p>We initially searched the following bibliographic databases: MEDLINE (Ovid), Embase (Elsevier), Cochrane Library (Wiley), CINAHL Complete (EBSCO), and PsycINFO (EBSCO). A MEDLINE search strategy was created using a combination of Medical Subject Headings (MeSH) and keywords for the concepts of COVID-19, screen time, and pediatrics. All team members reviewed the strategy and results; with team approval, the search was customized using controlled vocabulary (when available) and keywords in Embase, Cochrane Library, and PsycINFO (<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>). As of November 2021, all resulting citations were exported into an EndNote 20 (Clarivate Analytics) library with duplicates removed [<xref ref-type="bibr" rid="ref13">13</xref>]. The resulting collection of citations was then imported into Covidence for screening. In August 2022, the search was run again in all bibliographic databases and any unique citations were imported into Covidence. Finally, in February 2023, the search was rerun given the refinement of the research question to include validated measures of depression and anxiety and to capture new studies that had been recently published. This was done again in MEDLINE and PsycINFO and also included CINAHL. All articles were imported and screened in Covidence.</p></sec><sec id="s2-3"><title>Data Collection Process</title><p>Two reviewers independently extracted data from each article and the extracted data were sent to the research team for consensus. The following data were extracted from each study: the first author, the date and place of publication, the number of participants enrolled, participant demographics, measures/assessments used, study start and end date, inclusion criteria, findings summary, and effect sizes. The extracted data were collected in Covidence. Any disagreements were resolved in discussions with the research team.</p><p>Screen time during the COVID-19 pandemic, including problematic use that was excessive or disordered (eg, video games, smartphone or computer use, social media use), was defined through self-reports of screen time duration. Anxiety was defined using self-report standardized questionnaires as well as standardized parent report measures on anxiety symptoms. Depression was defined using self-report standardized questionnaires as well as standardized parent report measures on depressive symptoms.</p></sec><sec id="s2-4"><title>Study Risk of Bias Assessment</title><p>The STROBE (Strengthening the Reporting of Observational studies in Epidemiology) checklist was used to assess the quality of included studies on a scale from 0 to 21 (<xref ref-type="table" rid="table1">Table 1</xref>) [<xref ref-type="bibr" rid="ref14">14</xref>]. Two reviewers assessed each study independently and then met to achieve consensus.</p><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>STROBE (Strengthening the Reporting of Observational studies in Epidemiology) checklist for bias assessment.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom"/><td align="left" valign="bottom" colspan="2">Introduction</td><td align="left" valign="bottom" colspan="4">Methods</td><td align="left" valign="bottom" colspan="2">Results</td><td align="left" valign="bottom" colspan="2">Discussion</td><td align="left" valign="bottom"/></tr><tr><td align="left" valign="top">ID</td><td align="left" valign="top">Background</td><td align="left" valign="top">Objectives</td><td align="left" valign="top">Participants</td><td align="left" valign="top">Variables</td><td align="left" valign="top">Data/measures</td><td align="left" valign="top">Statistical methods</td><td align="left" valign="top">Descriptive data</td><td align="left" valign="top">Outcomes</td><td align="left" valign="top">Results</td><td align="left" valign="top">Limitations</td><td align="left" valign="top">Total</td></tr></thead><tbody><tr><td align="left" valign="top">1 [<xref ref-type="bibr" rid="ref15">15</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">20</td></tr><tr><td align="left" valign="top">2 [<xref ref-type="bibr" rid="ref16">16</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">20</td></tr><tr><td align="left" valign="top">3 [<xref ref-type="bibr" rid="ref17">17</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">20</td></tr><tr><td align="left" valign="top">4 [<xref ref-type="bibr" rid="ref18">18</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">20</td></tr><tr><td align="left" valign="top">5 [<xref ref-type="bibr" rid="ref19">19</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">0</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">18</td></tr><tr><td align="left" valign="top">6 [<xref ref-type="bibr" rid="ref20">20</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">20</td></tr><tr><td align="left" valign="top">7 [<xref ref-type="bibr" rid="ref21">21</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">1</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">19</td></tr><tr><td align="left" valign="top">8 [<xref ref-type="bibr" rid="ref22">22</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">20</td></tr><tr><td align="left" valign="top">9 [<xref ref-type="bibr" rid="ref23">23</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">20</td></tr><tr><td align="left" valign="top">10 [<xref ref-type="bibr" rid="ref24">24</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">20</td></tr><tr><td align="left" valign="top">11 [<xref ref-type="bibr" rid="ref25">25</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">1</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">19</td></tr><tr><td align="left" valign="top">12 [<xref ref-type="bibr" rid="ref26">26</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">20</td></tr><tr><td align="left" valign="top">13 [<xref ref-type="bibr" rid="ref27">27</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">20</td></tr><tr><td align="left" valign="top">14 [<xref ref-type="bibr" rid="ref28">28</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">20</td></tr><tr><td align="left" valign="top">15 [<xref ref-type="bibr" rid="ref29">29</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">20</td></tr><tr><td align="left" valign="top">16 [<xref ref-type="bibr" rid="ref30">30</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">1</td><td align="left" valign="top">19</td></tr><tr><td align="left" valign="top">17 [<xref ref-type="bibr" rid="ref30">30</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">20</td></tr><tr><td align="left" valign="top">18 [<xref ref-type="bibr" rid="ref11">11</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">19</td></tr><tr><td align="left" valign="top">19 [<xref ref-type="bibr" rid="ref31">31</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">20</td></tr><tr><td align="left" valign="top">20 [<xref ref-type="bibr" rid="ref32">32</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">20</td></tr><tr><td align="left" valign="top">21 [<xref ref-type="bibr" rid="ref33">33</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">20</td></tr><tr><td align="left" valign="top">22 [<xref ref-type="bibr" rid="ref34">34</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">1</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">19</td></tr><tr><td align="left" valign="top">23 [<xref ref-type="bibr" rid="ref35">35</xref>]</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">1</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">2</td><td align="left" valign="top">19</td></tr></tbody></table></table-wrap></sec><sec id="s2-5"><title>Effect Measures, Synthesis Methods, and Analyses</title><p>Fisher <italic>r</italic>-to-<italic>z</italic> transformation was used as the effect measure to quantify the relationship between screen time, anxiety, and depression, and results were converted back to Pearson correlations for interpretation. Studies were excluded if they were missing sufficient summary statistics and/or were unconvertible into appropriate effect sizes. Studies reported in other effect measures were converted to correlations using the conversion formulas proposed by Borenstein et al [<xref ref-type="bibr" rid="ref14">14</xref>]. If a study assessed the same outcome with more than one measure, the average effect size was used in the analysis [<xref ref-type="bibr" rid="ref36">36</xref>].</p><p>A random-effects model was used for all meta-analysis to account for heterogeneity across studies. Pooled correlations of <italic>r</italic>=0.10, <italic>r</italic>=0.30, and <italic>r</italic>=0.50 were considered as small, medium, and large effect sizes, respectively [<xref ref-type="bibr" rid="ref37">37</xref>]. Heterogeneity (ie, <inline-formula><mml:math id="ieqn1"><mml:msup><mml:mrow><mml:mi>&#x03C4;</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msup></mml:math></inline-formula>) was assessed using the restricted maximum-likelihood estimator. In addition to the estimation of <inline-formula><mml:math id="ieqn2"><mml:msup><mml:mrow><mml:mi>&#x03C4;</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msup></mml:math></inline-formula>, the <italic>Q</italic> test for heterogeneity and the <italic>I</italic><sup>2</sup> statistics are also reported [<xref ref-type="bibr" rid="ref38">38</xref>]. Forest plots were generated for each outcome to visualize individual study effects and pooled estimates. Funnel plots were used to detect potential publication bias. Meta-regression analysis was performed to assess the impact of age, gender, and the definition of screen time (duration of use vs problematic use) on the effect sizes [<xref ref-type="bibr" rid="ref39">39</xref>]. To evaluate the robustness of the results, sensitivity analysis was conducted by excluding studies identified as potential outliers or exerting excessive influence on the pooled effect using studentized residuals and the Cook distance [<xref ref-type="bibr" rid="ref40">40</xref>]. All statistical analyses were performed using RStudio (version 4.4.1; Posit PBC) and the <italic>metafor</italic> package [<xref ref-type="bibr" rid="ref41">41</xref>].</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><sec id="s3-1"><title>Search Results and Included Studies</title><p>In the initial database search, 6504 records were obtained. After duplicate removal, the titles and abstracts of 6462 records were screened independently by 7 coders based on the predefined eligibility criteria. After the title and abstract screening, 452 articles were retained. Following full-text screening, 429 articles were excluded from the systematic review, and 23 articles totaling 29,581 children and adolescents were retained in the systematic review and meta-analysis. See <xref ref-type="fig" rid="figure1">Figure 1</xref> for the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram of observational studies.</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>PRISMA flowchart for studies of screen time during the COVID-19 pandemic and pediatric mental health. PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="pediatrics_v9i1e83228_fig01.png"/></fig></sec><sec id="s3-2"><title>Study Characteristics</title><p>Across the 23 studies (<xref ref-type="table" rid="table2">Table 2</xref>), children and adolescents were 8 to &#x003C;18 years of age, with a mean age of 13.54 (SD 0.43) years; in addition, 49% (n=14,390) were male and 51% (n=15,191) were female. Of the 23 studies, 39% (n=9) were from North America, 44% (n=10) were from Asia, and 17% (n=4) were from Europe. Studies were published globally in the following countries: United States (n=6), China (n=6), Canada (n=3), Hong Kong (n=1), Hungary (n=1), Italy (n=2), India (n=1), Iran (n=1), Poland (n=1), and South Korea (n=1). Of the 23 studies, 96% (n=22) examined depression, 83% (n=19) examined anxiety, and 78% (n=18) examined both depression and anxiety.</p><table-wrap id="t2" position="float"><label>Table 2.</label><caption><p>Characteristics of studies.</p></caption><table id="table2" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">ID</td><td align="left" valign="bottom">Author</td><td align="left" valign="bottom">Country</td><td align="left" valign="bottom">Sample size (N)</td><td align="left" valign="bottom">Male (%)</td><td align="left" valign="bottom">Age (years)</td><td align="left" valign="bottom">Screen time</td><td align="left" valign="bottom">Depression</td><td align="left" valign="bottom">Anxiety</td></tr></thead><tbody><tr><td align="left" valign="top">1a</td><td align="left" valign="top">Alves et al, 2021 [<xref ref-type="bibr" rid="ref15">15</xref>]</td><td align="left" valign="top">United States</td><td align="left" valign="top">30</td><td align="left" valign="top">43</td><td align="left" valign="top">11.7</td><td align="left" valign="top">Duration</td><td align="left" valign="top">PANAS-C<sup><xref ref-type="table-fn" rid="table2fn1">a</xref></sup></td><td align="left" valign="top">STAIC<sup><xref ref-type="table-fn" rid="table2fn2">b</xref></sup></td></tr><tr><td align="left" valign="top">1b</td><td align="left" valign="top">Alves et al, 2021 [<xref ref-type="bibr" rid="ref15">15</xref>]</td><td align="left" valign="top">United States</td><td align="left" valign="top">34</td><td align="left" valign="top">32</td><td align="left" valign="top">11.9</td><td align="left" valign="top">Duration</td><td align="left" valign="top">PANAS-C</td><td align="left" valign="top">STAIC</td></tr><tr><td align="left" valign="top">2</td><td align="left" valign="top">Berki et al, 2021 [<xref ref-type="bibr" rid="ref16">16</xref>]</td><td align="left" valign="top">Hungary</td><td align="left" valign="top">705</td><td align="left" valign="top">37</td><td align="left" valign="top">15.9</td><td align="left" valign="top">Duration</td><td align="left" valign="top">CDI<sup><xref ref-type="table-fn" rid="table2fn3">c</xref></sup></td><td align="left" valign="top">N/A</td></tr><tr><td align="left" valign="top">3</td><td align="left" valign="top">Charmaraman et al, 2022 [<xref ref-type="bibr" rid="ref17">17</xref>]</td><td align="left" valign="top">United States</td><td align="left" valign="top">900</td><td align="left" valign="top">47</td><td align="left" valign="top">12.53</td><td align="left" valign="top">Duration</td><td align="left" valign="top">CESDR-10<sup><xref ref-type="table-fn" rid="table2fn4">d</xref></sup></td><td align="left" valign="top">SADS<sup><xref ref-type="table-fn" rid="table2fn5">e</xref></sup></td></tr><tr><td align="left" valign="top">4</td><td align="left" valign="top">Chen et al, 2021 [<xref ref-type="bibr" rid="ref18">18</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">1357</td><td align="left" valign="top">50</td><td align="left" valign="top">10.71</td><td align="left" valign="top">Duration</td><td align="left" valign="top">DASS-21<sup><xref ref-type="table-fn" rid="table2fn6">f</xref></sup></td><td align="left" valign="top">DASS-21</td></tr><tr><td align="left" valign="top">5</td><td align="left" valign="top">De Pasquale et al, 2021 [<xref ref-type="bibr" rid="ref42">42</xref>]</td><td align="left" valign="top">Italy</td><td align="left" valign="top">162</td><td align="left" valign="top">48.2</td><td align="left" valign="top">9.4</td><td align="left" valign="top">Problematic use</td><td align="left" valign="top">N/A</td><td align="left" valign="top">CAM-S<sup><xref ref-type="table-fn" rid="table2fn7">g</xref></sup></td></tr><tr><td align="left" valign="top">6</td><td align="left" valign="top">Ellis et al, 2020 [<xref ref-type="bibr" rid="ref19">19</xref>]</td><td align="left" valign="top">Canada</td><td align="left" valign="top">1054</td><td align="left" valign="top">21.9</td><td align="left" valign="top">16.68</td><td align="left" valign="top">Duration</td><td align="left" valign="top">BSI<sup><xref ref-type="table-fn" rid="table2fn8">h</xref></sup></td><td align="left" valign="top">N/A</td></tr><tr><td align="left" valign="top">7</td><td align="left" valign="top">Fazeli et al, 2020 [<xref ref-type="bibr" rid="ref20">20</xref>]</td><td align="left" valign="top">Iran</td><td align="left" valign="top">1512</td><td align="left" valign="top">56.4</td><td align="left" valign="top">15.51</td><td align="left" valign="top">Problematic use</td><td align="left" valign="top">DASS</td><td align="left" valign="top">DASS</td></tr><tr><td align="left" valign="top">8</td><td align="left" valign="top">Lee et al, 2021 [<xref ref-type="bibr" rid="ref21">21</xref>]</td><td align="left" valign="top">South Korea</td><td align="left" valign="top">264</td><td align="left" valign="top">100</td><td align="left" valign="top">17.57</td><td align="left" valign="top">Problematic use</td><td align="left" valign="top">CES-D<sup><xref ref-type="table-fn" rid="table2fn9">i</xref></sup></td><td align="left" valign="top">N/A</td></tr><tr><td align="left" valign="top">9</td><td align="left" valign="top">Liu et al, 2022 [<xref ref-type="bibr" rid="ref22">22</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">5581</td><td align="left" valign="top">48.5</td><td align="left" valign="top">13.8</td><td align="left" valign="top">Problematic use</td><td align="left" valign="top">SDS<sup><xref ref-type="table-fn" rid="table2fn10">j</xref></sup></td><td align="left" valign="top">SAS<sup><xref ref-type="table-fn" rid="table2fn11">k</xref></sup></td></tr><tr><td align="left" valign="top">10</td><td align="left" valign="top">McArthur et al, 2021 [<xref ref-type="bibr" rid="ref23">23</xref>]</td><td align="left" valign="top">Canada</td><td align="left" valign="top">846</td><td align="left" valign="top">52.8</td><td align="left" valign="top">9.85</td><td align="left" valign="top">Duration</td><td align="left" valign="top">BASC-3<sup><xref ref-type="table-fn" rid="table2fn12">l</xref></sup></td><td align="left" valign="top">BASC-3</td></tr><tr><td align="left" valign="top">11</td><td align="left" valign="top">Moitra et al, 2021 [<xref ref-type="bibr" rid="ref24">24</xref>]</td><td align="left" valign="top">India</td><td align="left" valign="top">1298</td><td align="left" valign="top">53.3</td><td align="left" valign="top">13.2</td><td align="left" valign="top">Duration</td><td align="left" valign="top">PHQ<sup><xref ref-type="table-fn" rid="table2fn13">m</xref></sup>-2</td><td align="left" valign="top">N/A</td></tr><tr><td align="left" valign="top">12</td><td align="left" valign="top">Mousavi et al, 2022 [<xref ref-type="bibr" rid="ref25">25</xref>]</td><td align="left" valign="top">United States</td><td align="left" valign="top">215</td><td align="left" valign="top">51.2</td><td align="left" valign="top">15.63</td><td align="left" valign="top">Duration</td><td align="left" valign="top">DASS</td><td align="left" valign="top">DASS</td></tr><tr><td align="left" valign="top">13</td><td align="left" valign="top">Murata et al, 2021 [<xref ref-type="bibr" rid="ref26">26</xref>]</td><td align="left" valign="top">United States</td><td align="left" valign="top">583</td><td align="left" valign="top">20</td><td align="left" valign="top">15.8</td><td align="left" valign="top">Duration</td><td align="left" valign="top">PHQ-9</td><td align="left" valign="top">GAD<sup><xref ref-type="table-fn" rid="table2fn14">n</xref></sup> -7</td></tr><tr><td align="left" valign="top">14</td><td align="left" valign="top">Muzi et al, 2021 [<xref ref-type="bibr" rid="ref27">27</xref>]</td><td align="left" valign="top">Italy</td><td align="left" valign="top">62</td><td align="left" valign="top">37</td><td align="left" valign="top">15.43</td><td align="left" valign="top">Problematic use</td><td align="left" valign="top">YSR<sup><xref ref-type="table-fn" rid="table2fn15">o</xref></sup> 11&#x2010;18</td><td align="left" valign="top">YSR 11&#x2010;18</td></tr><tr><td align="left" valign="top">15</td><td align="left" valign="top">Ren et al, 2021 [<xref ref-type="bibr" rid="ref28">28</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">1771</td><td align="left" valign="top">51.8</td><td align="left" valign="top">N/A</td><td align="left" valign="top">Duration</td><td align="left" valign="top">PHQ-9</td><td align="left" valign="top">GAD-7</td></tr><tr><td align="left" valign="top">16</td><td align="left" valign="top">Sikorska et al, 2021 [<xref ref-type="bibr" rid="ref29">29</xref>]</td><td align="left" valign="top">Poland</td><td align="left" valign="top">370</td><td align="left" valign="top">32.7</td><td align="left" valign="top">15.38</td><td align="left" valign="top">Duration</td><td align="left" valign="top">DASS-21</td><td align="left" valign="top">DASS-21</td></tr><tr><td align="left" valign="top">17a</td><td align="left" valign="top">Tandon et al, old, 2021 [<xref ref-type="bibr" rid="ref30">30</xref>]</td><td align="left" valign="top">United States</td><td align="left" valign="top">500</td><td align="left" valign="top">50.5</td><td align="left" valign="top">14</td><td align="left" valign="top">Duration</td><td align="left" valign="top">SDQ<sup><xref ref-type="table-fn" rid="table2fn16">p</xref></sup></td><td align="left" valign="top">SDQ</td></tr><tr><td align="left" valign="top">17b</td><td align="left" valign="top">Tandon et al, young, 2021 [<xref ref-type="bibr" rid="ref30">30</xref>]</td><td align="left" valign="top">United States</td><td align="left" valign="top">500</td><td align="left" valign="top">52.6</td><td align="left" valign="top">8</td><td align="left" valign="top">Duration</td><td align="left" valign="top">SDQ</td><td align="left" valign="top">SDQ</td></tr><tr><td align="left" valign="top">18</td><td align="left" valign="top">Tao et al, 2021 [<xref ref-type="bibr" rid="ref11">11</xref>]</td><td align="left" valign="top">United States</td><td align="left" valign="top">407</td><td align="left" valign="top">17.7</td><td align="left" valign="top">16.47</td><td align="left" valign="top">Duration</td><td align="left" valign="top">CES-D</td><td align="left" valign="top">GAD-7</td></tr><tr><td align="left" valign="top">19</td><td align="left" valign="top">Tardif-Grenier et al, 2021 [<xref ref-type="bibr" rid="ref31">31</xref>]</td><td align="left" valign="top">Canada</td><td align="left" valign="top">895</td><td align="left" valign="top">26.3</td><td align="left" valign="top">14.69</td><td align="left" valign="top">Duration</td><td align="left" valign="top">CES-D</td><td align="left" valign="top">SCARED-R<sup><xref ref-type="table-fn" rid="table2fn17">q</xref></sup></td></tr><tr><td align="left" valign="top">20</td><td align="left" valign="top">Teng et al, 2021 [<xref ref-type="bibr" rid="ref32">32</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">1778</td><td align="left" valign="top">50.7</td><td align="left" valign="top">N/A</td><td align="left" valign="top">Duration</td><td align="left" valign="top">CES-D</td><td align="left" valign="top">STAI<sup><xref ref-type="table-fn" rid="table2fn18">r</xref></sup></td></tr><tr><td align="left" valign="top">21</td><td align="left" valign="top">Xiang et al, 2022 [<xref ref-type="bibr" rid="ref33">33</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">2423</td><td align="left" valign="top">51.2</td><td align="left" valign="top">10.5</td><td align="left" valign="top">Duration</td><td align="left" valign="top">DASS-21</td><td align="left" valign="top">DASS-21</td></tr><tr><td align="left" valign="top">22</td><td align="left" valign="top">Zhang et al, 2022 [<xref ref-type="bibr" rid="ref34">34</xref>]</td><td align="left" valign="top">China</td><td align="left" valign="top">3471</td><td align="left" valign="top">51.6</td><td align="left" valign="top">14.1</td><td align="left" valign="top">Duration</td><td align="left" valign="top">PHQ-9</td><td align="left" valign="top">GAD-7</td></tr><tr><td align="left" valign="top">23</td><td align="left" valign="top">Zhu et al, 2021 [<xref ref-type="bibr" rid="ref35">35</xref>]</td><td align="left" valign="top">Hong Kong</td><td align="left" valign="top">2863</td><td align="left" valign="top">59</td><td align="left" valign="top">12.6</td><td align="left" valign="top">Problematic use</td><td align="left" valign="top">PHQ-9</td><td align="left" valign="top">GAD-7</td></tr></tbody></table><table-wrap-foot><fn id="table2fn1"><p><sup>a</sup>PANAS-C: Positive and Negative Affect Scale - Child Form.</p></fn><fn id="table2fn2"><p><sup>b</sup>STAIC: State-Trait Anxiety Inventory for Children.</p></fn><fn id="table2fn3"><p><sup>c</sup>CDI: Children&#x2019;s Depression Inventory.</p></fn><fn id="table2fn4"><p><sup>d</sup>CESDR-10: Center for Epidemiologic Studies Depression Scale Revised.</p></fn><fn id="table2fn5"><p><sup>e</sup>SADS: Social Avoidance and Distress Scale.</p></fn><fn id="table2fn6"><p><sup>f</sup>DASS-21: Depression Anxiety Stress Scale.</p></fn><fn id="table2fn7"><p><sup>g</sup>CAM-S: Child Anxiety Meter-State.</p></fn><fn id="table2fn8"><p><sup>h</sup>BSI: Brief Symptom Inventory.</p></fn><fn id="table2fn9"><p><sup>i</sup>CES-D: The Center for Epidemiologic Studies Depression Scale.</p></fn><fn id="table2fn10"><p><sup>j</sup>SDS: Self-Rating Depression Scale.</p></fn><fn id="table2fn11"><p><sup>k</sup>SAS: Self-Rating Anxiety Scale.</p></fn><fn id="table2fn12"><p><sup>l</sup>BASC-3: Behavior Assessment System for Children-Third Edition.</p></fn><fn id="table2fn13"><p><sup>m</sup>PHQ: Patient Health Questionnaire.</p></fn><fn id="table2fn14"><p><sup>n</sup>GAD-7: Generalized Anxiety Disorder 7-item.</p></fn><fn id="table2fn15"><p><sup>o</sup>YSR: Youth Self-Report.</p></fn><fn id="table2fn16"><p><sup>p</sup>SDQ: Strengths and Difficulties Questionnaire.</p></fn><fn id="table2fn17"><p><sup>q</sup>SCARED-R: Screen for Child Anxiety Related Disorders-Revised.</p></fn><fn id="table2fn18"><p><sup>r</sup>STAI: State Trait Anxiety Inventory.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-3"><title>Risk of Bias in Studies</title><p>The STROBE checklist [<xref ref-type="bibr" rid="ref14">14</xref>] was used to assess the quality of studies and any potential bias as seen in <xref ref-type="table" rid="table1">Table 1</xref>. Two independent reviewers assessed each study, resulting in a possible score from 0 to 20. Each section of the STROBE checklist had a potential score of 0 to 2, with 0 meaning criteria were not met, 1 meaning criteria were partially met, and 2 meaning criteria were fully met. Two reviewers ranked the scores, and any disagreements were discussed with a third reviewer to achieve consensus. All studies used validated questionnaires for depression and anxiety. McArthur et al [<xref ref-type="bibr" rid="ref23">23</xref>] used a large longitudinal cohort, which allowed for examination of differences over time. The majority of studies were cross-sectional and were conducted during the global pandemic, which did not allow for examination of causal relationships. The following studies were found to have a lower quality assessment. De Pasquale et al [<xref ref-type="bibr" rid="ref42">42</xref>] did not provide any information on the statistical tests that were conducted in the methods. Fazeli et al [<xref ref-type="bibr" rid="ref20">20</xref>] had limited information on the statistical methods. Moitra and Madan [<xref ref-type="bibr" rid="ref24">24</xref>] conducted a mediation analysis on a cross-sectional study but did not indicate the temporal order in their survey methods. Zhu et al [<xref ref-type="bibr" rid="ref35">35</xref>] imputed more than 25% of missing data. Sikorska et al [<xref ref-type="bibr" rid="ref29">29</xref>] did not adequately address potential limitations.</p></sec><sec id="s3-4"><title>Screen Time and Depression</title><p>Twenty-two of the 23 included studies (all except [<xref ref-type="bibr" rid="ref42">42</xref>]) reported comparable effect sizes for screen time and depression. Two studies [<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref30">30</xref>] presented results only for stratified subgroups rather than an overall sample. Therefore, we treated the stratified groups as separate studies in the analysis and increased the sample size to 24 for the analysis. The observed correlation coefficients ranged from &#x2212;0.00160 to 0.620. The random-effects model revealed a significant, positive, small estimated pooled correlation (<italic>r</italic>=0.175, 95% CI 0.124-0.226; <italic>P</italic>&#x003C;.001; <italic>I</italic><sup>2</sup>=94%). According to the <italic>Q</italic> test, the true estimates appear to be heterogeneous (<italic>Q</italic><sub>23</sub>=644.22, <italic>P</italic>&#x003C;.001, <inline-formula><mml:math id="ieqn3"><mml:msup><mml:mrow><mml:mi>&#x03C4;</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msup></mml:math></inline-formula>=0.0138, <italic>I</italic><sup>2</sup>=95%). A forest plot showing the observed and the estimated correlation is shown in <xref ref-type="fig" rid="figure2">Figure 2</xref> [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref15">15</xref>-<xref ref-type="bibr" rid="ref31">31</xref>,<xref ref-type="bibr" rid="ref33">33</xref>-<xref ref-type="bibr" rid="ref35">35</xref>]. Meta-regression showed no significant associations of depression with age and gender.</p><fig position="float" id="figure2"><label>Figure 2.</label><caption><p>Forest plot for depression.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="pediatrics_v9i1e83228_fig02.png"/></fig><p>A funnel plot of the estimates is shown in <xref ref-type="fig" rid="figure3">Figure 3</xref>. The plot is reasonably symmetrical around the pooled estimate, indicating no strong evidence of publication bias or small-study effects. Both the Cook distance and studentized residuals showed that one study [<xref ref-type="bibr" rid="ref22">22</xref>] could be overly influential. Sensitivity analysis was conducted by removing the study. The result from the sensitivity analysis remained stable after removing the potential outlier (<italic>r</italic>=0.158, 95% CI 0.114-0.202; <italic>P</italic>&#x003C;.001), supporting the result from the main analysis. Although <italic>I</italic><sup>2</sup> decreased from 95% to 90%, heterogeneity remained high across studies.</p><fig position="float" id="figure3"><label>Figure 3.</label><caption><p>Funnel plot for depression.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="pediatrics_v9i1e83228_fig03.png"/></fig></sec><sec id="s3-5"><title>Screen Time and Anxiety</title><p>A total of 19 studies reported correlation coefficients for screen time and anxiety, ranging from &#x2212;0.00390 to 0.450. Since the results from Alves et al [<xref ref-type="bibr" rid="ref15">15</xref>] and Tandon et al [<xref ref-type="bibr" rid="ref30">30</xref>] were reported as two stratified subgroups, it increased the total sample size to 21 for the analysis. A random-effects model for screen time and anxiety again indicated a significant yet small estimated pooled correlation (<italic>r</italic>=0.157, 95% CI 0.0994-0.214; <italic>P</italic>&#x003C;.001), with a <italic>Q</italic> test (<italic>Q</italic><sub>20</sub>=760.16, <italic>P</italic>&#x003C;.001,<inline-formula><mml:math id="ieqn4"><mml:msup><mml:mrow><mml:mi>&#x03C4;</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msup></mml:math></inline-formula>=0.0150, <italic>I</italic><sup>2</sup>=95%) demonstrating high heterogeneity. A forest plot showing the observed and estimated correlations is shown in <xref ref-type="fig" rid="figure4">Figure 4</xref> [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref15">15</xref>,<xref ref-type="bibr" rid="ref17">17</xref>,<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref20">20</xref>,<xref ref-type="bibr" rid="ref22">22</xref>,<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref25">25</xref>-<xref ref-type="bibr" rid="ref30">30</xref>,<xref ref-type="bibr" rid="ref33">33</xref>-<xref ref-type="bibr" rid="ref35">35</xref>,<xref ref-type="bibr" rid="ref42">42</xref>]. Meta-regression revealed that compared to studies where screen time was measured as duration of use, those defining it as problematic use have an average 0.1585 higher Fisher <italic>z</italic> score for the correlation between screen time and anxiety. In terms of correlation, this translates to roughly a 0.15 increase, indicating a stronger correlation with anxiety in studies with problematic use.</p><fig position="float" id="figure4"><label>Figure 4.</label><caption><p>Forest plot for anxiety.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="pediatrics_v9i1e83228_fig04.png"/></fig></sec><sec id="s3-6"><title>Certainty of Evidence</title><p>The funnel plot in <xref ref-type="fig" rid="figure5">Figure 5</xref> was fairly symmetrical around the pooled effect size visually, with no indication of publication bias or small-study effects. The same study [<xref ref-type="bibr" rid="ref22">22</xref>] was considered to be an outlier based on the Cook distance and studentized residual. The result from the sensitivity analysis yielded a slightly lower but still significant correlation (<italic>r</italic>=0.135, 95% CI 0.0890-0.181; <italic>P</italic>&#x003C;.001), supporting the result from the main analysis. Although <italic>I</italic><sup>2</sup> decreased from 95% to 89%, heterogeneity remained high overall, suggesting the true effect varies across different studies.</p><fig position="float" id="figure5"><label>Figure 5.</label><caption><p>Funnel plot for anxiety.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="pediatrics_v9i1e83228_fig05.png"/></fig></sec></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><sec id="s4-1"><title>Principal Findings</title><p>This meta-analysis of a total of 23 global studies examined screen time and mental health outcomes among 29,581 children and adolescents during the COVID-19 pandemic. Screen time had a significant, positive, small estimated pooled correlation with increased depression (22 studies) and increased anxiety (19 studies). Problematic screen use that was excessive or disordered had a stronger correlation with anxiety than average screen use. Age and gender did not influence mental health outcomes; most youth were adolescents and gender was equally distributed. Sensitivity analyses for studies with outliers for depression and anxiety supported the results from the main analysis.</p><p>Although various studies examined different types of screen time during the pandemic, results remained the same. Studies reported greater time spent on social media was associated with higher depressive [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref19">19</xref>] and anxiety symptoms [<xref ref-type="bibr" rid="ref11">11</xref>]. Zhu et al [<xref ref-type="bibr" rid="ref35">35</xref>] reported pathological gaming behavior (as compared to excessive, leisure, and none) was associated with increased depression and anxiety. Berki et al [<xref ref-type="bibr" rid="ref16">16</xref>] reported that more hours of daily screen time (time spent using electronic devices such as a computer, tablet, or smartphone) were associated with higher depressive symptoms. Studies also found that a greater number of hours spent on video games and social media predicted higher depressive [<xref ref-type="bibr" rid="ref18">18</xref>,<xref ref-type="bibr" rid="ref26">26</xref>,<xref ref-type="bibr" rid="ref43">43</xref>] and anxiety [<xref ref-type="bibr" rid="ref18">18</xref>] symptoms and negative perceived well-being [<xref ref-type="bibr" rid="ref44">44</xref>].</p></sec><sec id="s4-2"><title>Strengths</title><p>There were various strengths in this meta-analysis. A rigorous process was implemented, with multiple reviewers using a systematic approach to achieve consensus when screening studies for eligibility and extracting data from studies that met eligibility criteria. Additionally, depression and anxiety were measured using validated questionnaires, and the meta-analysis methodology provided precision in the estimate of the effect size, which increased the validity and generalizability of the findings. Extracted studies included pooled data from 10 countries in North America, Europe, and Asia, further increasing the generalizability of the findings. Sensitivity analyses demonstrated the robustness of the study results. Finally, the COVID-19 pandemic was a global emergency that served as a natural experiment and magnified the conditions to allow youth to participate in excessive screen time, providing a rare opportunity with high statistical power to examine the impact on mental health outcomes.</p></sec><sec id="s4-3"><title>Limitations</title><p>There were limitations in this study. Most studies examined the negative impact of screen time, which may have introduced some bias. Given the unprecedented nature of the global pandemic, most studies were cross-sectional, allowing for the examination of the relationship between screen time and increased depression or anxiety at one point in time. The results are not generalizable to all age groups as the cohort mostly consisted of adolescents, with a mean age of 13.54 years. More information is needed about how the COVID-19 pandemic impacted school-age (6&#x2010;12 year olds) and young children (0&#x2010;5 year olds). Screen time was also measured through youth self-reports or parent reports, which may not accurately reflect the amount of time spent on screens due to recall bias. It is possible that other factors aside from screen time, such as the adjustment to the online schooling format and/or cybervictimization, may have impacted anxiety and depression. Since this study included data from multiple countries, there may have been different methods for collecting and tracking data, and it is possible that some mental health data could have been underreported.</p></sec><sec id="s4-4"><title>Clinical Implications</title><p>During the pandemic, children and adolescents with increased screen time were negatively impacted in terms of depression and anxiety due to higher levels of screen time. These findings suggest the need for ongoing assessment of children and adolescents&#x2019; quality and quantity of screen behaviors to identify risk factors to prevent or treat mental health outcomes, especially in the event of another global or national emergency. More research is needed to develop a validated tool to assess screen time [<xref ref-type="bibr" rid="ref45">45</xref>,<xref ref-type="bibr" rid="ref46">46</xref>]. Given the significance of screen time in the lives of youth, it is important to consider how to address unhealthy media habits that may increase during a pandemic. The American Academy of Pediatrics recommends the 5 Cs of Media Use to promote healthy media habits [<xref ref-type="bibr" rid="ref47">47</xref>]. This includes Child, Content, Calm, Crowding Out, and Communication. Practitioners should work with families to develop family media plans that address rules around screen time, balancing family and media time, conversations around responsible social media use, teaching emotion regulation strategies, parental modeling of screen use, and monitoring content for quality, developmental appropriateness, and privacy. Additionally, pediatricians can provide anticipatory guidance to help children and families prepare for emergencies, such as a global pandemic [<xref ref-type="bibr" rid="ref48">48</xref>]. Children and adolescents should learn from an early age about the benefits and risks of screen use, with an emphasis on developing healthy screen habits that maximize positive social interactions, learning, and recreation; increasing awareness of safety factors such as the protection of privacy; and creating self-awareness that will guard against the negative impacts on mental health related to screen overuse. Finally, promoting positive childhood experiences during a global emergency may help to buffer negative impacts of excessive screen time on mental health outcomes by nurturing healthy social-emotional development.</p></sec><sec id="s4-5"><title>Conclusion</title><p>This meta-analysis includes the evidence from 23 studies on screen time and mental health. During the COVID-19 pandemic, children and adolescents with higher levels of screen time had increased depression and/or anxiety. These data suggest the need for ongoing parent, professional, and self-monitoring of youth screen behaviors and habits as well as activities that promote social connectedness during global or national health emergencies.</p></sec></sec></body><back><notes><sec><title>Funding</title><p>This work was supported by the Biostatistics, Informatics and Data Management Core at The Saban Research Institute, Children's Hospital Los Angeles, and by grant UL1TR001855 from the National Center for Advancing Translational Science (NCATS) of the U.S. National Institutes of Health. 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