<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "journalpublishing.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="2.0" xml:lang="en" article-type="research-article"><front><journal-meta><journal-id journal-id-type="nlm-ta">JMIR Pediatr Parent</journal-id><journal-id journal-id-type="publisher-id">pediatrics</journal-id><journal-id journal-id-type="index">30</journal-id><journal-title>JMIR Pediatrics and Parenting</journal-title><abbrev-journal-title>JMIR Pediatr Parent</abbrev-journal-title><issn pub-type="epub">2561-6722</issn><publisher><publisher-name>JMIR Publications</publisher-name><publisher-loc>Toronto, Canada</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">v7i1e63416</article-id><article-id pub-id-type="doi">10.2196/63416</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Paper</subject></subj-group></article-categories><title-group><article-title>Web-Based Parent Training With Telephone Coaching Aimed at Treating Child Disruptive Behaviors in a Clinical Setting During the COVID-19 Pandemic: Single-Group Study With 2-Year Follow-Up</article-title></title-group><contrib-group><contrib contrib-type="author"><name name-style="western"><surname>Sourander</surname><given-names>Saana</given-names></name><degrees>RN, MHc</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Westerlund</surname><given-names>Minja</given-names></name><degrees>PsyD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Baumel</surname><given-names>Amit</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Hinkka-Yli-Salom&#x00E4;ki</surname><given-names>Susanna</given-names></name><degrees>PhLic</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Ristkari</surname><given-names>Terja</given-names></name><degrees>RN, MNS</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name name-style="western"><surname>Kurki</surname><given-names>Marjo</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author" corresp="yes"><name name-style="western"><surname>Sourander</surname><given-names>Andre</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="aff" rid="aff5">5</xref></contrib></contrib-group><aff id="aff1"><institution>Research Centre for Child Psychiatry, University of Turku</institution><addr-line>Turku</addr-line><country>Finland</country></aff><aff id="aff2"><institution>INVEST Research Flagship Centre, University of Turku</institution><addr-line>Turku</addr-line><country>Finland</country></aff><aff id="aff3"><institution>Department of Community Mental Health, University of Haifa</institution><addr-line>Haifa</addr-line><country>Israel</country></aff><aff id="aff4"><institution>ITLA Children's Foundation</institution><addr-line>Helsinki</addr-line><country>Finland</country></aff><aff id="aff5"><institution>Department of Child Psychiatry, Turku University Hospital</institution><addr-line>Turku</addr-line><country>Finland</country></aff><contrib-group><contrib contrib-type="editor"><name name-style="western"><surname>Badawy</surname><given-names>Sherif</given-names></name></contrib></contrib-group><contrib-group><contrib contrib-type="reviewer"><name name-style="western"><surname>Friedmann</surname><given-names>Anna</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Xu</surname><given-names>Juncai</given-names></name></contrib><contrib contrib-type="reviewer"><name name-style="western"><surname>Salari</surname><given-names>Raziye</given-names></name></contrib></contrib-group><author-notes><corresp>Correspondence to Andre Sourander, MD, PhD, Research Centre for Child Psychiatry, University of Turku, Lemmink&#x00E4;isenkatu 3a, 3rd Floor, Turku, 20014, Finland, 358 50 365 3447; <email>andre.sourander@utu.fi</email></corresp></author-notes><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>16</day><month>12</month><year>2024</year></pub-date><volume>7</volume><elocation-id>e63416</elocation-id><history><date date-type="received"><day>20</day><month>06</month><year>2024</year></date><date date-type="rev-recd"><day>08</day><month>10</month><year>2024</year></date><date date-type="accepted"><day>10</day><month>10</month><year>2024</year></date></history><copyright-statement>&#x00A9; Saana Sourander, Minja Westerlund, Amit Baumel, Susanna Hinkka-Yli-Salom&#x00E4;ki, Terja Ristkari, Marjo Kurki, Andre Sourander. Originally published in JMIR Pediatrics and Parenting (<ext-link ext-link-type="uri" xlink:href="https://pediatrics.jmir.org">https://pediatrics.jmir.org</ext-link>), 16.12.2024. </copyright-statement><copyright-year>2024</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Pediatrics and Parenting, is properly cited. The complete bibliographic information, a link to the original publication on <ext-link ext-link-type="uri" xlink:href="https://pediatrics.jmir.org">https://pediatrics.jmir.org</ext-link>, as well as this copyright and license information must be included.</p></license><self-uri xlink:type="simple" xlink:href="https://pediatrics.jmir.org/2024/1/e63416"/><abstract><sec><title>Background</title><p>There is a lack of studies examining the long-term outcomes of web-based parent training programs implemented in clinical settings during the COVID-19 pandemic.</p></sec><sec><title>Objective</title><p>The aim is to study 2-year outcomes of families with 3&#x2010; to 8-year-old children referred from family counseling centers to the Finnish Strongest Families Smart Website (SFSW), which provides digital parent training with telephone coaching aimed at treating child disruptive behaviors.</p></sec><sec sec-type="methods"><title>Methods</title><p>Counseling centers in Helsinki identified fifty 3&#x2010; to 8-year-old children with high levels of disruptive behavioral problems. Child psychopathology and functioning as well as parenting styles and parental mental health were collected from parents at baseline; posttreatment; and at 6-, 12-, and 24-month follow-ups.</p></sec><sec sec-type="results"><title>Results</title><p>The SFSW program had positive long-term changes in child psychopathology and parenting skills. Improvements in child psychopathology, including Strengths and Difficulties Questionnaire total score (Cohen <italic>d</italic>=0.47; <italic>P</italic>&#x003C;.001), Strengths and Difficulties Questionnaire conduct scores (Cohen <italic>d</italic>=0.65; <italic>P</italic>&#x003C;.001), and Affective Reactivity Index irritability scores (Cohen <italic>d</italic>=0.52; <italic>P</italic>&#x003C;.001), were maintained until the 24-month follow-up. Similarly, changes in parenting skills measured with the Parenting Scale, including overreactivity (Cohen <italic>d</italic>=0.41; <italic>P</italic>=.001) and laxness (Cohen <italic>d</italic>=0.26; <italic>P</italic>=.02), were maintained until the 24-month follow-up. However, parental hostility changes were not maintained at long-term follow-up (Cohen <italic>d</italic>=&#x2212;0.04; <italic>P</italic>=.70).</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>The study shows that the SFSW parent training program can yield significant long-term benefits. Findings indicate that the benefits of the treatment may vary between different parenting styles, which is important to consider when developing more personalized parenting interventions.</p></sec></abstract><kwd-group><kwd>parent training</kwd><kwd>disruptive behavior</kwd><kwd>child psychopathology</kwd><kwd>child functioning</kwd><kwd>behaviors</kwd><kwd>behavioral</kwd><kwd>coaching</kwd><kwd>web-based</kwd><kwd>family counseling</kwd><kwd>child</kwd><kwd>disruptive</kwd><kwd>counseling</kwd><kwd>training</kwd><kwd>parents</kwd><kwd>parenting</kwd><kwd>telephone</kwd><kwd>telehealth</kwd><kwd>telemedicine</kwd><kwd>pediatrics</kwd><kwd>COVID-19</kwd></kwd-group></article-meta></front><body><sec id="s1" sec-type="intro"><title>Introduction</title><p>There is growing evidence from randomized controlled trials (RCTs) that parents can be trained to intervene and reduce child disruptive behaviors and improve their parenting skills [<xref ref-type="bibr" rid="ref1">1</xref>-<xref ref-type="bibr" rid="ref3">3</xref>]. Parent training has been found to be the most effective way to prevent and treat disruptive behaviors (patterns of, eg, defiant, disobedient, hostile, and externalizing behavior) among children [<xref ref-type="bibr" rid="ref4">4</xref>-<xref ref-type="bibr" rid="ref6">6</xref>] and is considered one of the most-validated therapeutic techniques in child mental health [<xref ref-type="bibr" rid="ref7">7</xref>]. In the face of the unmet need for accessible evidence-based treatment programs to tackle early-onset childhood disruptive behaviors, digitally administered remote treatments provide solutions that require fewer personnel, that may be less stigmatizing, and that can reach geographically remote areas [<xref ref-type="bibr" rid="ref8">8</xref>,<xref ref-type="bibr" rid="ref9">9</xref>]. Examining the long-term outcomes of an intervention is an essential step in ensuring the sustainability of its effects. A recent meta-analysis on RCTs showed that parenting interventions based on social learning theory are effective in reducing physical and emotional violence at immediate posttest, but effects decrease over time [<xref ref-type="bibr" rid="ref10">10</xref>]. However, to our knowledge, there are no long-term follow-ups (ie, more than 12 months) of digital parent training interventions in clinical settings. The Finnish Strongest Families Smart Website (SFSW) intervention is an 11-week program that includes parent training delivered through a digital platform and assisted by weekly telephone coaching. Previously, we conducted an RCT, screening families at regular health checkups for 4-year-old children. Children who had parent-reported high levels of disruptive behavior were screened for targeted SFSW intervention. The sample included 232 children in each study group, an intervention group, and an educational control group. At a 24-month follow-up after randomization, the results maintained efficacy in reducing a wide range of child psychopathology and improving parenting skills [<xref ref-type="bibr" rid="ref11">11</xref>].</p><p>Child behavior problems are associated with psychological distress and financial costs and with a poor long-term outlook if they are not addressed [<xref ref-type="bibr" rid="ref1">1</xref>]. Early intervention is crucial to help mitigate these impacts and support healthier development trajectories. This study targets an important gap in the current literature on long-term follow-ups of digital parent training interventions in clinical settings. We assessed the long-term outcomes of families participating in the SFSW parent training program in a clinical setting at baseline and at 12 and 24 months after baseline. A unique contribution of this study is that the SFSW parent training program was administered to the study cohort during the worst phase of the COVID-19 pandemic when the Helsinki capital region was partially isolated from other parts of Finland. Other services were severely limited, albeit the need for services was great. The SFSW program was an already existing, empirically tested, and, importantly, digitalized intervention targeting children&#x2019;s disruptive behavior problems. Due to the crisis, it was considered ethically inappropriate to conduct a randomized controlled study design in this study. The program completion rate was high. The 6-month follow-up findings of this program were very promising and have been reported previously [<xref ref-type="bibr" rid="ref12">12</xref>]. There were significant changes in most of the child psychopathology measures, including the Child Behavior Checklist (CBCL) externalizing score (mean 7.0, 95% CI 4.9&#x2010;9.0; <italic>P</italic>&#x003C;.001), and when parenting skills were measured with the Parenting Scale (PS), the results showed significant changes in the total score (mean 0.5, 95% CI 0.4&#x2010;0.7; <italic>P</italic>&#x003C;.001) [<xref ref-type="bibr" rid="ref12">12</xref>].</p><p>Our aim with this paper is to report long-term changes in children&#x2019;s functioning, psychopathology levels, parenting skills, and well-being from baseline until the 24-month follow-up. We hypothesized that the previously reported positive effects of the SFSW at the 6-month follow-up [<xref ref-type="bibr" rid="ref12">12</xref>] would be at least partly maintained at the 24-month follow-up.</p></sec><sec id="s2" sec-type="methods"><title>Methods</title><sec id="s2-1"><title>Study Population</title><p>The study included families with children between the ages of 3 and 8 years who exhibited elevated levels of disruptive behavior when screened by professionals from 8 different family counseling centers in Helsinki. Family counseling centers operate under social services and provide low-threshold services. The centers contribute to child development by reinforcing parenting skills and family relationships. They provide direct support, offer advice to assisting services, and facilitate referrals to specialized services. At family counseling centers, parent training that addresses child-rearing challenges is offered through individual or group sessions. The recruitment was based on identified needs. Health care and social welfare professionals from the counseling centers identified families that were in need of support for child disruptive behavior and selected families who were suitable for the remotely administered SFSW parent training program. During the pandemic lockdowns, face-to-face sessions were not possible, underscoring the importance of remote support methods.</p></sec><sec id="s2-2"><title>Ethical Considerations</title><p>Ethics approval for the study was received from the ethics committee of the University of Turku (statement 25/2018), and the study also received a research permit from the city of Helsinki (HEL 2020-006651). Parents provided written informed consent and were advised that participation in the study was voluntary and they had the right to withdraw at any time. This is a single-group study design with repeated measurements. Parents completed questionnaires at baseline; posttreatment; and at 6, 12, and 24 months after starting the program. The study encompassed 50 families and took place from May 2020 to November 2022. Earlier findings comparing baseline, posttreatment, and 6-month follow-up results have been reported previously [<xref ref-type="bibr" rid="ref12">12</xref>].</p></sec><sec id="s2-3"><title>Recruitment, Eligibility, and Procedure</title><p>The professionals identified children with high levels of disruptive behavior problems. In addition, parents completed the Strengths and Difficulties Questionnaire (SDQ) [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref14">14</xref>] and were included if their child had a high level of conduct problems (&#x2265;5 points in the SDQ conduct scale) and if the parents perceived their child to have difficulties concerning emotions, behavior, or social interactions based on one item inquiring parents about these aspects. Additionally, inclusion in the study required at least 1 parent to be a native Finnish or Swedish speaker with access to both a telephone and a device with internet connectivity. Exclusion criteria were if a child had been diagnosed with autism, Down syndrome, fetal alcohol syndrome, an intellectual disability, or severe mental disorders, which would indicate a need for services beyond the scope of the digital SFSW program. Eligible families were invited to participate and directed to the SFSW website to provide their formal consent and fill in the baseline questionnaires. Commencing with the completion of baseline questionnaires, participants progressed through SFSW. A flowchart on the study procedures is provided in in<xref ref-type="supplementary-material" rid="app1">Multimedia Appendix 1</xref>.</p></sec><sec id="s2-4"><title>Intervention</title><p>The SFSW parent training program used digital materials (eg, psychoeducational material, video clips, and home exercises) and telephone coaching. The program focused on enhancing skills to improve parent-child relationships, complemented by weekly telephone sessions conducted by trained family coaches&#x2014;licensed health care professionals, including nurses and public health nurses. The content of each web-based session included an introduction, session content, video exercises, troubleshooting, review, and practical application of the new skills. Each session featured multimedia components and digital exercises, and parents were encouraged to complete the session before the next phone call. All coaching calls were systematically recorded and subjected to random audits by the coach supervisor to ensure fidelity. The telephone sessions were scheduled at the end of the previous weekly call for a duration of 1 hour each. The family coach followed up in case the family missed an appointment, and possible rescheduling of coaching sessions was done per SMS text message or email contact by the parent.</p><p>The SFSW program has previously been shown to be effective [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref15">15</xref>] and can successfully make the transition to implementation settings [<xref ref-type="bibr" rid="ref12">12</xref>,<xref ref-type="bibr" rid="ref16">16</xref>,<xref ref-type="bibr" rid="ref17">17</xref>]. <xref ref-type="table" rid="table1">Table 1</xref> includes an outline of the weekly themes covered in SFSW. The program was sequential, that is, the parents completed 1-week theme before moving to the next. The primary goal was for parents to recognize positive behaviors in their children and respond positively. The second aim was to apply learned skills in everyday situations, using positive methods to reinforce the child&#x2019;s positive behavior. The end of the program focused on solidifying the application of newfound positive parenting skills in daily life to support the child&#x2019;s positive behavior. Parents practiced these skills with their children and discussed their progress during weekly telephone calls with their family coach, which were scheduled aiming to ensure sustainability beyond the program&#x2019;s completion. As previously reported [<xref ref-type="bibr" rid="ref12">12</xref>], the average time spent on the program website for each of the 11 themes was 48.0 (SD 25.6) minutes, and the mean duration of telephone coaching was 35.3 (SD 8.8) minutes per call. The total mean duration per theme, including both digital materials and telephone coaching, was 83.3 (SD 28.0) minutes.</p><table-wrap id="t1" position="float"><label>Table 1.</label><caption><p>Themes of the SFSW<sup><xref ref-type="table-fn" rid="table1fn1">a</xref></sup> web-based parent training program for children with behavioral problems.</p></caption><table id="table1" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom">Session</td><td align="left" valign="bottom">Goals</td></tr></thead><tbody><tr><td align="left" valign="top">1. Notice the good</td><td align="left" valign="top">Boost the child&#x2019;s self-esteem, boost the parent&#x2019;s self-esteem, and change the parent&#x2019;s view of their child</td></tr><tr><td align="left" valign="top">2. Spread attention around</td><td align="left" valign="top">Strengthen the child&#x2019;s empathy skills</td></tr><tr><td align="left" valign="top">3. Ignore whining and complaining</td><td align="left" valign="top">Teach parents self-regulation</td></tr><tr><td align="left" valign="top">4. Prepare for changes</td><td align="left" valign="top">Reinforce good daily routines</td></tr><tr><td align="left" valign="top">5. Plan ahead at home</td><td align="left" valign="top">Boost the self-esteem of the child and parent and involve the child in planning</td></tr><tr><td align="left" valign="top">6. Chart and stickers</td><td align="left" valign="top">Involve the child in planning and reinforce good daily routines</td></tr><tr><td align="left" valign="top">7. Plan ahead outside the home</td><td align="left" valign="top">Boost the self-esteem of the child and parent and involve the child in planning</td></tr><tr><td align="left" valign="top">8. Working with daycare</td><td align="left" valign="top">Help the child to manage and succeed</td></tr><tr><td align="left" valign="top">9. Time-out</td><td align="left" valign="top">Teach self-regulation and consistency</td></tr><tr><td align="left" valign="top">10 and 11. Problem-solving revision and future application of skills</td><td align="left" valign="top">Teach parents skills to support child development and prepare for future challenges</td></tr><tr><td align="left" valign="top">12. Booster</td><td align="left" valign="top">Remind parents of positive proactive parenting skills</td></tr></tbody></table><table-wrap-foot><fn id="table1fn1"><p><sup>a</sup>SFSW: Strongest Families Smart Website.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s2-5"><title>Measurements</title><p>The parents completed questionnaires at baseline, after the program, and at 6, 12, and 24 months after they had started the program. In addition, demographic details of the family, children, and parents were collected during the screening phase. All of the measurements used in this study have demonstrated adequate reliability and criterion validity metrics and were described more extensively in our previous paper [<xref ref-type="bibr" rid="ref12">12</xref>]. For brevity, we mention them briefly below, while a comprehensive description is provided in <xref ref-type="supplementary-material" rid="app2">Multimedia Appendix 2</xref>.</p></sec><sec id="s2-6"><title>Child Psychopathology and Functioning</title><p>Child psychopathology was assessed using the Finnish version of the 25-item SDQ [<xref ref-type="bibr" rid="ref13">13</xref>,<xref ref-type="bibr" rid="ref14">14</xref>], which measures challenges the child experiences in emotions, behavior, or social interactions [<xref ref-type="bibr" rid="ref18">18</xref>]. Perceived difficulties were gauged through a single question regarding challenges in emotions, behavior, or social interactions, with response options ranging from no difficulties to severe difficulties. Disruptive behavior was gauged by the externalizing subscale of the CBCL for ages 1.5&#x2010;5 years (99 items) [<xref ref-type="bibr" rid="ref19">19</xref>], focusing on an externalizing subscale with 24 items related to attention issues and aggressive behavior (our primary outcome) along with the CBCL&#x2019;s total score. Child irritability was measured by the Affective Reactivity Index (ARI), which includes 6 irritability symptom items and 1 impairment item [<xref ref-type="bibr" rid="ref20">20</xref>]. A 17-item questionnaire, derived from Barkley&#x2019;s Home Situations Questionnaire [<xref ref-type="bibr" rid="ref21">21</xref>], measured the parents&#x2019; experiences of their child&#x2019;s functioning and behavior in daily situations. We used the 24-item Inventory of Callous-Unemotional Traits (ICU) [<xref ref-type="bibr" rid="ref22">22</xref>] to assess 3 precursors of child psychopathy: callousness, uncaring, and unemotional traits [<xref ref-type="bibr" rid="ref23">23</xref>,<xref ref-type="bibr" rid="ref24">24</xref>].</p></sec><sec id="s2-7"><title>Parenting, Parental Mental Health, and Satisfaction</title><p>The PS, a 30-item tool, was used to evaluate 3 dysfunctional parenting discipline styles: laxness, overreactivity, and hostility, reflecting rule enforcement, responses to mistakes, and using verbal or physical force, respectively [<xref ref-type="bibr" rid="ref25">25</xref>,<xref ref-type="bibr" rid="ref26">26</xref>]. We used the 21-item Depression, Anxiety, and Stress Scale (DASS-21) to assess parental stress, anxiety, and depression symptoms in the past week [<xref ref-type="bibr" rid="ref27">27</xref>].</p></sec><sec id="s2-8"><title>Statistical Analysis</title><p>Descriptive statistics include numbers and percentages for categorical variables and means and SDs for continuous variables. The categorical variables were analyzed with Pearson chi-square or Fisher exact tests and the continuous variables with 2-sample 2-tailed <italic>t</italic> test. We analyzed the outcome variables using linear mixed-effect models for repeated measurements with time as a within-factor. The modeling framework enables to use restricted maximum estimation method, which handles data with missing observations. Therefore, there was no need to apply any separate imputation method. We used linear contrasts to estimate changes from baseline to 12 and 24 months as well as changes from 12 to 24 months. We included the sex, age, and maternal education of the children as covariates in all models. The McNemar test was applied to test the change in the number of children with a total SDQ score above the 90th percentile (ie, abnormal range) at baseline and at the 24-month follow-up. The effect sizes of all outcome variables were calculated as 2-tailed <italic>t</italic> test effect sizes using Cohen <italic>d</italic>. The statistical analyses were performed using SAS statistical software (version 9.4; SAS Institute Inc).</p></sec></sec><sec id="s3" sec-type="results"><title>Results</title><sec id="s3-1"><title>Participant Characteristics</title><p>The study comprised 50 families who were referred to the program, of which 44 (88%) completed the whole 11-week SFSW program. In total, 24-month follow-up assessments were obtained from 37 (74%) families. As shown in <xref ref-type="table" rid="table2">Table 2</xref>, 37 (74%) of the 50 children were boys. A total of 48 (96%) children had definitive or severe behavioral problems at baseline, and only 2 (4%) had minor behavioral problems based on a single item in the parent report, &#x201C;Overall, do you think that your child has difficulties in 1 or more of the following areas: emotions, behavior, or being able to get on with other people?&#x201D; <xref ref-type="table" rid="table2">Table 2</xref> also presents a comparison between the families who completed the 24-month follow-up and those who did not. The table shows the difference in maternal education&#x2014;in the noncompleter group, mothers were less educated. The completers and noncompleters did not differ on parenting style measures or psychopathology symptoms.</p><table-wrap id="t2" position="float"><label>Table 2.</label><caption><p>Baseline characteristics of enrolled families, and comparison between families completing and those not completing the 24-month follow-up measurements.</p></caption><table id="table2" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom" colspan="3">Baseline characteristics</td><td align="left" valign="bottom">All families (n=50)</td><td align="left" valign="bottom">Families completing the 24-month follow-up (n=37)</td><td align="left" valign="bottom">Families not completing 24-month follow-up (n=13)</td><td align="left" valign="bottom"><italic>P</italic> value<sup><xref ref-type="table-fn" rid="table2fn1">a</xref></sup></td></tr></thead><tbody><tr><td align="left" valign="top" colspan="7"><bold>Family and parent characteristics</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="5"><bold>Family structure, n (%)</bold></td><td align="left" valign="top">.21</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Biological parents</td><td align="left" valign="top">38 (76)</td><td align="left" valign="top">30 (81)</td><td align="left" valign="top">8 (62)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">One biological parent</td><td align="left" valign="top">11 (22)</td><td align="left" valign="top">6 (16)</td><td align="left" valign="top">5 (38)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Other</td><td align="left" valign="top">1 (2)</td><td align="left" valign="top">1 (3)</td><td align="left" valign="top">0 (0)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="6"><bold>Age (years), mean (SD)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Maternal</td><td align="left" valign="top">31.9 (4.3)</td><td align="left" valign="top">31.9 (3.5)</td><td align="left" valign="top">31.6 (6.2)</td><td align="left" valign="top">.86</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Paternal</td><td align="left" valign="top">32.8 (3.7)</td><td align="left" valign="top">32.3 (3.6)</td><td align="left" valign="top">34.5 (3.7)</td><td align="left" valign="top">.10</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="5"><bold>Maternal educational level<sup><xref ref-type="table-fn" rid="table2fn2">b</xref></sup>, n (%)</bold></td><td align="left" valign="top">.047</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">College or university degree</td><td align="left" valign="top">38 (78)</td><td align="left" valign="top">31 (86)</td><td align="left" valign="top">7 (54)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Lower</td><td align="left" valign="top">11 (22)</td><td align="left" valign="top">5 (14)</td><td align="left" valign="top">6 (46)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="5"><bold>Paternal educational level<sup><xref ref-type="table-fn" rid="table2fn3">c</xref></sup>, n (%</bold>)</td><td align="left" valign="top">.46</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">College or university degree</td><td align="left" valign="top">32 (70)</td><td align="left" valign="top">23 (66)</td><td align="left" valign="top">9 (82)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Lower</td><td align="left" valign="top">14 (30)</td><td align="left" valign="top">12 (34)</td><td align="left" valign="top">2 (18)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="5"><bold>Mother&#x2019;s native language, n (%)</bold></td><td align="left" valign="top">.55</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Finnish</td><td align="left" valign="top">45 (90)</td><td align="left" valign="top">34 (92)</td><td align="left" valign="top">11 (85)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Swedish</td><td align="left" valign="top">3 (6)</td><td align="left" valign="top">2 (5)</td><td align="left" valign="top">1 (8)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Other</td><td align="left" valign="top">2 (4)</td><td align="left" valign="top">1 (3)</td><td align="left" valign="top">1 (8)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="5"><bold>Father&#x2019;s native language<sup><xref ref-type="table-fn" rid="table2fn3">c</xref></sup>, n (%)</bold></td><td align="left" valign="top">.21</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Finnish</td><td align="left" valign="top">37 (80)</td><td align="left" valign="top">29 (83)</td><td align="left" valign="top">8 (73)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Swedish</td><td align="left" valign="top">3 (7)</td><td align="left" valign="top">1 (3)</td><td align="left" valign="top">2 (18)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Other</td><td align="left" valign="top">6 (13)</td><td align="left" valign="top">5 (14)</td><td align="left" valign="top">1 (9)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="6"><bold>Parenting Scale, mean (SD)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Total</td><td align="left" valign="top">3.5 (0.5)</td><td align="left" valign="top">3.5 (0.5)</td><td align="left" valign="top">3.5 (0.3)</td><td align="left" valign="top">.81</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Laxness</td><td align="left" valign="top">2.8 (0.8)</td><td align="left" valign="top">2.8 (0.8)</td><td align="left" valign="top">2.8 (0.7)</td><td align="left" valign="top">.95</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Overreactivity</td><td align="left" valign="top">4.3 (1.2)</td><td align="left" valign="top">4.1 (1.2)</td><td align="left" valign="top">4.6 (1.2)</td><td align="left" valign="top">.25</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Hostility</td><td align="left" valign="top">1.9 (0.8)</td><td align="left" valign="top">1.8 (0.8)</td><td align="left" valign="top">1.9 (0.8)</td><td align="left" valign="top">.71</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="6"><bold>DASS-21<sup><xref ref-type="table-fn" rid="table2fn4">d</xref></sup>, mean (SD)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Total</td><td align="left" valign="top">22.6 (14.9)</td><td align="left" valign="top">20.8 (14.2)</td><td align="left" valign="top">28.0 (16.3)</td><td align="left" valign="top">.13</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Depression</td><td align="left" valign="top">6.6 (7.1)</td><td align="left" valign="top">5.3 (5.8)</td><td align="left" valign="top">10.5 (9.1)</td><td align="left" valign="top">.07</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Anxiety</td><td align="left" valign="top">2.8 (4.3)</td><td align="left" valign="top">2.9 (4.3)</td><td align="left" valign="top">2.6 (4.6)</td><td align="left" valign="top">.86</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Stress</td><td align="left" valign="top">13.2 (6.6)</td><td align="left" valign="top">12.6 (6.9)</td><td align="left" valign="top">14.9 (5.6)</td><td align="left" valign="top">.28</td></tr><tr><td align="left" valign="top" colspan="7"><bold>Child characteristics</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="5"><bold>Sex, n (%)</bold></td><td align="left" valign="top">.14</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Female</td><td align="left" valign="top">13 (26)</td><td align="left" valign="top">12 (32)</td><td align="left" valign="top">1 (8)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Male</td><td align="left" valign="top">37 (74)</td><td align="left" valign="top">25 (68)</td><td align="left" valign="top">12 (92)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="5"><bold>Age (years), n (%)</bold></td><td align="left" valign="top">.33</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">3&#x2010;5</td><td align="left" valign="top">30 (60)</td><td align="left" valign="top">24 (65)</td><td align="left" valign="top">6 (46)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">6&#x2010;8</td><td align="left" valign="top">20 (40)</td><td align="left" valign="top">13 (35)</td><td align="left" valign="top">7 (54)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="5"><bold>Behavioral problems, n (%)</bold></td><td align="left" valign="top">.43</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Minor</td><td align="left" valign="top">2 (4)</td><td align="left" valign="top">2 (5)</td><td align="left" valign="top">0 (0)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Definite</td><td align="left" valign="top">30 (60)</td><td align="left" valign="top">20 (54)</td><td align="left" valign="top">10 (77)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Severe</td><td align="left" valign="top">18 (36)</td><td align="left" valign="top">15 (41)</td><td align="left" valign="top">3 (23)</td><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="6"><bold>CBCL/1.5&#x2010;5<sup><xref ref-type="table-fn" rid="table2fn5">e</xref></sup>, mean (SD)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Total</td><td align="left" valign="top">62.1 (22)</td><td align="left" valign="top">63.6 (21.9)</td><td align="left" valign="top">57.7 (22.6)</td><td align="left" valign="top">.41</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Externalizing</td><td align="left" valign="top">25.7 (7)</td><td align="left" valign="top">26.0 (6.9)</td><td align="left" valign="top">24.9 (7.6)</td><td align="left" valign="top">.63</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="6"><bold>SDQ<sup><xref ref-type="table-fn" rid="table2fn6">f</xref></sup>, mean (SD)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Total</td><td align="left" valign="top">19.8 (4.8)</td><td align="left" valign="top">20.2 (4.6)</td><td align="left" valign="top">18.5 (5.1)</td><td align="left" valign="top">.26</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Emotional</td><td align="left" valign="top">3.5 (2.3)</td><td align="left" valign="top">3.7 (2.2)</td><td align="left" valign="top">3.0 (2.5)</td><td align="left" valign="top">.34</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Conduct</td><td align="left" valign="top">7.5 (1.4)</td><td align="left" valign="top">7.5 (1.4)</td><td align="left" valign="top">7.2 (1.5)</td><td align="left" valign="top">.50</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Hyperactivity</td><td align="left" valign="top">6.0 (2.4)</td><td align="left" valign="top">6.1 (2.3)</td><td align="left" valign="top">5.5 (2.5)</td><td align="left" valign="top">.46</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Peer</td><td align="left" valign="top">2.8 (1.9)</td><td align="left" valign="top">2.9 (1.9)</td><td align="left" valign="top">2.7 (2.0)</td><td align="left" valign="top">.78</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Prosocial</td><td align="left" valign="top">5.2 (2.0)</td><td align="left" valign="top">5.1 (2.1)</td><td align="left" valign="top">5.2 (1.7)</td><td align="left" valign="top">.88</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Impact</td><td align="left" valign="top">3.0 (1.7)</td><td align="left" valign="top">3.0 (1.6)</td><td align="left" valign="top">2.9 (2.1)</td><td align="left" valign="top">.93</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="6"><bold>ARI<sup><xref ref-type="table-fn" rid="table2fn7">g</xref></sup>, mean (SD)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Irritability</td><td align="left" valign="top">8.6 (3.2)</td><td align="left" valign="top">8.7 (3.0)</td><td align="left" valign="top">8.4 (3.7)</td><td align="left" valign="top">.74</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="6"><bold>ICU<sup><xref ref-type="table-fn" rid="table2fn8">h</xref></sup>, mean (SD)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Total</td><td align="left" valign="top">27.4 (7.7)</td><td align="left" valign="top">26.5 (7.3)</td><td align="left" valign="top">30.1 (8.6)</td><td align="left" valign="top">.16</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Callousness</td><td align="left" valign="top">8.9 (3.6)</td><td align="left" valign="top">8.5 (3.5)</td><td align="left" valign="top">10.0 (3.8)</td><td align="left" valign="top">.19</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Uncaring</td><td align="left" valign="top">14.5 (3.5)</td><td align="left" valign="top">14.2 (3.6)</td><td align="left" valign="top">15.2 (3.3)</td><td align="left" valign="top">.37</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Unemotional</td><td align="left" valign="top">4.1 (3.0)</td><td align="left" valign="top">3.8 (2.7)</td><td align="left" valign="top">4.8 (3.8)</td><td align="left" valign="top">.30</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="6"><bold>Everyday situations (child behavior), mean (SD)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Total</td><td align="left" valign="top">42.9 (11.3)</td><td align="left" valign="top">43.8 (11.2)</td><td align="left" valign="top">40.3 (11.7)</td><td align="left" valign="top">.34</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Transition situations</td><td align="left" valign="top">14.7 (4.4)</td><td align="left" valign="top">14.9 (4.4)</td><td align="left" valign="top">14.2 (4.7)</td><td align="left" valign="top">.65</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Dining situations</td><td align="left" valign="top">7.8 (3.0)</td><td align="left" valign="top">8.1 (3.0)</td><td align="left" valign="top">7.0 (2.9)</td><td align="left" valign="top">.27</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Situations outside home</td><td align="left" valign="top">10.4 (3.3)</td><td align="left" valign="top">10.8 (3.3)</td><td align="left" valign="top">9.5 (3.3)</td><td align="left" valign="top">.23</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Home situations</td><td align="left" valign="top">10.0 (3.1)</td><td align="left" valign="top">10.1 (3.1)</td><td align="left" valign="top">9.6 (3.5)</td><td align="left" valign="top">.63</td></tr></tbody></table><table-wrap-foot><fn id="table2fn1"><p><sup>a</sup>Refers to statistical test comparing families completing the 24-month follow-up to those who did not.</p></fn><fn id="table2fn2"><p><sup>b</sup>One missing observation.</p></fn><fn id="table2fn3"><p><sup>c</sup>Four missing observations.</p></fn><fn id="table2fn4"><p><sup>d</sup>DASS-21: 21-item Depression, Anxiety, and Stress Scale.</p></fn><fn id="table2fn5"><p><sup>e</sup>CBCL/1.5&#x2010;5: Child Behavior Checklist for preschool children.</p></fn><fn id="table2fn6"><p><sup>f</sup>SDQ: Strengths and Difficulties Questionnaire.</p></fn><fn id="table2fn7"><p><sup>g</sup>ARI: Affective Reactivity Index.</p></fn><fn id="table2fn8"><p><sup>h</sup>ICU: Inventory of Callous-Unemotional Traits.</p></fn></table-wrap-foot></table-wrap></sec><sec id="s3-2"><title>Long-Term Changes in Child and Parenting Measures</title><p>Descriptive statistics of child psychopathology, child function level, parental skills, and parental mental health at baseline and at 12 and 24 months after baseline are presented in <xref ref-type="table" rid="table3">Table 3</xref>. A statistical comparison of the different time points is presented in <xref ref-type="table" rid="table4">Table 4</xref>. In terms of child psychopathology, significant improvements between baseline and the 12-month follow-up as well as between baseline and the 24-month follow-up were found in CBCL total scores and externalizing scores, SDQ total scores and most subscales (emotional, conduct, hyperactivity, and peer problems), and irritability measured with the ARI scale. At the same time, there was a significant deterioration in CBCL total and externalizing scores and SDQ prosocial behavior scores between the 12-month and 24-month follow-ups.</p><table-wrap id="t3" position="float"><label>Table 3.</label><caption><p>Child psychopathology, child functioning level, parental skills, and parental mental health at baseline and 12 months and 24 months after the baseline (n=50).</p></caption><table id="table3" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom" colspan="3">Variable</td><td align="left" valign="bottom">Baseline<sup><xref ref-type="table-fn" rid="table3fn1">a</xref></sup>, mean<sup><xref ref-type="table-fn" rid="table3fn2">b</xref></sup> (SE)</td><td align="left" valign="bottom">12 months<sup><xref ref-type="table-fn" rid="table3fn3">c</xref></sup>, mean (SE)</td><td align="left" valign="bottom">24 months<sup><xref ref-type="table-fn" rid="table3fn4">d</xref></sup>, mean (SE)</td></tr></thead><tbody><tr><td align="left" valign="top" colspan="6"><bold>Child psychopathology</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="5"><bold>CBCL/1.5-5</bold><sup><xref ref-type="table-fn" rid="table3fn5"><bold>e</bold></xref></sup></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Total</td><td align="left" valign="top">61.8 (5.5)</td><td align="left" valign="top">43.8 (5.8)</td><td align="left" valign="top">50.2 (5.9)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Externalizing</td><td align="left" valign="top">25.5 (1.9)</td><td align="left" valign="top">18.0 (2.2)</td><td align="left" valign="top">20.2 (2.2)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="2"><bold>SDQ</bold><sup><xref ref-type="table-fn" rid="table3fn6"><bold>f</bold></xref></sup></td><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top"/></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Total</td><td align="left" valign="top">19.8 (1.1)</td><td align="left" valign="top">14.4 (1.3)</td><td align="left" valign="top">15.3 (1.3)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Emotional symptoms</td><td align="left" valign="top">3.5 (0.5)</td><td align="left" valign="top">2.1 (0.5)</td><td align="left" valign="top">2.7 (0.5)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Conduct problems</td><td align="left" valign="top">7.3 (0.4)</td><td align="left" valign="top">5.1 (0.4)</td><td align="left" valign="top">5.2 (0.5)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Hyperactivity</td><td align="left" valign="top">6.8 (0.6)</td><td align="left" valign="top">5.5 (0.7)</td><td align="left" valign="top">5.7 (0.7)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Peer problems</td><td align="left" valign="top">2.1 (0.4)</td><td align="left" valign="top">1.5 (0.4)</td><td align="left" valign="top">1.5 (0.5)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Prosocial behavior</td><td align="left" valign="top">5.6 (0.5)</td><td align="left" valign="top">6.4 (0.5)</td><td align="left" valign="top">5.8 (0.5)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Impact</td><td align="left" valign="top">3.2 (0.4)</td><td align="left" valign="top">2.0 (0.4)</td><td align="left" valign="top">2.7 (0.4)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="5"><bold>ARI</bold><sup><xref ref-type="table-fn" rid="table3fn7"><bold>g</bold></xref></sup></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Irritability</td><td align="left" valign="top">9.3 (0.8)</td><td align="left" valign="top">6.2 (0.8)</td><td align="left" valign="top">6.4 (0.8)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="5"><bold>ICU</bold><sup><xref ref-type="table-fn" rid="table3fn8"><bold>h</bold></xref></sup></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Total</td><td align="left" valign="top">25.9 (1.8)</td><td align="left" valign="top">22.5 (2.0)</td><td align="left" valign="top">24.1 (2.0)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Callousness</td><td align="left" valign="top">8.1 (0.8)</td><td align="left" valign="top">6.2 (0.9)</td><td align="left" valign="top">6.1 (1.0)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Uncaring</td><td align="left" valign="top">14.0 (0.8)</td><td align="left" valign="top">12.0 (0.9)</td><td align="left" valign="top">13.3 (0.9)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Unemotional</td><td align="left" valign="top">4.2 (0.7)</td><td align="left" valign="top">4.6 (0.7)</td><td align="left" valign="top">5.1 (0.8)</td></tr><tr><td align="left" valign="top" colspan="6"><bold>Child functioning level</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="5"><bold>Everyday situations</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Child behavior&#x2014;total</td><td align="left" valign="top">42.4 (2.7)</td><td align="left" valign="top">33.4 (3.0)</td><td align="left" valign="top">33.6 (3.0)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Transition situations</td><td align="left" valign="top">13.9 (1.1)</td><td align="left" valign="top">10.5 (1.1)</td><td align="left" valign="top">11.1 (1.1)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Dining situations</td><td align="left" valign="top">7.8 (0.7)</td><td align="left" valign="top">6.7 (0.7)</td><td align="left" valign="top">6.4 (0.7)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Situations outside home</td><td align="left" valign="top">10.3 (0.8)</td><td align="left" valign="top">8.0 (0.8)</td><td align="left" valign="top">7.8 (0.8)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Home situations</td><td align="left" valign="top">10.3 (0.8)</td><td align="left" valign="top">8.0 (0.9)</td><td align="left" valign="top">8.2 (0.9)</td></tr><tr><td align="left" valign="top" colspan="6"><bold>Parental skills</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="5"><bold>Parenting Scale</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Total</td><td align="left" valign="top">3.5 (0.1)</td><td align="left" valign="top">3.1 (0.1)</td><td align="left" valign="top">3.2 (0.1)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Laxness</td><td align="left" valign="top">2.8 (0.2)</td><td align="left" valign="top">2.4 (0.2)</td><td align="left" valign="top">2.5 (0.2)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Overreactivity</td><td align="left" valign="top">4.4 (0.3)</td><td align="left" valign="top">3.6 (0.3)</td><td align="left" valign="top">3.8 (0.3)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Hostility</td><td align="left" valign="top">2.2 (0.2)</td><td align="left" valign="top">1.9 (0.2)</td><td align="left" valign="top">2.2 (0.2)</td></tr><tr><td align="left" valign="top" colspan="6"><bold>Parental mental health</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="5"><bold>DASS-21</bold><sup><xref ref-type="table-fn" rid="table3fn9"><bold>i</bold></xref></sup></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Total</td><td align="left" valign="top">24.4 (3.8)</td><td align="left" valign="top">20.3 (3.9)</td><td align="left" valign="top">23.5 (4.0)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Depression</td><td align="left" valign="top">8.2 (1.5)</td><td align="left" valign="top">6.7 (1.5)</td><td align="left" valign="top">7.7 (1.5)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Anxiety</td><td align="left" valign="top">2.7 (1.0)</td><td align="left" valign="top">2.9 (1.1)</td><td align="left" valign="top">3.4 (1.2)</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Stress</td><td align="left" valign="top">13.5 (1.7)</td><td align="left" valign="top">10.6 (1.8)</td><td align="left" valign="top">12.5 (1.9)</td></tr></tbody></table><table-wrap-foot><fn id="table3fn1"><p><sup>a</sup>Measurements before the program started.</p></fn><fn id="table3fn2"><p><sup>b</sup>Least-squares means.</p></fn><fn id="table3fn3"><p><sup>c</sup>Measurements at 12 months after starting the program.</p></fn><fn id="table3fn4"><p><sup>d</sup>Measurements at 24 months after starting the program.</p></fn><fn id="table3fn5"><p><sup>e</sup>CBCL/1.5&#x2010;5: Child Behavior Checklist for preschool children.</p></fn><fn id="table3fn6"><p><sup>f</sup>SDQ: Strengths and Difficulties Questionnaire.</p></fn><fn id="table3fn7"><p><sup>g</sup>ARI: Affective Reactivity Index.</p></fn><fn id="table3fn8"><p><sup>h</sup>ICU: Inventory of Callous-Unemotional Traits.</p></fn><fn id="table3fn9"><p><sup>i</sup>DASS-21: 21-item Depression, Anxiety, and Stress Scale.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t4" position="float"><label>Table 4.</label><caption><p>Changes from baseline to 12 months and 24 months after in child psychopathology, child function level, parental skills, and parental mental health.</p></caption><table id="table4" frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom" colspan="3">Variable</td><td align="left" valign="bottom" colspan="3">Baseline<sup><xref ref-type="table-fn" rid="table4fn1">a</xref></sup> to 12 months<sup><xref ref-type="table-fn" rid="table4fn2">b</xref></sup></td><td align="left" valign="bottom" colspan="3">Baseline to 24 months<sup><xref ref-type="table-fn" rid="table4fn3">c</xref></sup></td><td align="left" valign="bottom" colspan="2">12 months to 24 months</td></tr><tr><td align="left" valign="bottom" colspan="3"/><td align="left" valign="bottom">Mean (95% CI)</td><td align="left" valign="bottom"><italic>P</italic> value</td><td align="left" valign="bottom">Cohen <italic>d</italic></td><td align="left" valign="bottom">Mean (95% CI)</td><td align="left" valign="bottom"><italic>P</italic> value</td><td align="left" valign="bottom">Cohen <italic>d</italic></td><td align="left" valign="bottom">Mean (95% CI)</td><td align="left" valign="bottom"><italic>P</italic> value</td></tr></thead><tbody><tr><td align="left" valign="top" colspan="11"><bold>Child psychopathology</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="10"><bold>CBCL/1.5-5</bold><sup><xref ref-type="table-fn" rid="table4fn4"><bold>d</bold></xref></sup></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Total</td><td align="left" valign="top">17.4 (9.8 to 25.0)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.49</td><td align="left" valign="top">11.0 (3.5 to 18.5)</td><td align="left" valign="top">.005</td><td align="left" valign="top">0.32</td><td align="left" valign="top">&#x2212;6.4 (10.2 to &#x2212;2.7)</td><td align="left" valign="top">.001</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Externalizing</td><td align="left" valign="top">7.5 (4.7 to 9.9)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.66</td><td align="left" valign="top">5.2 (2.4 to 8.1)</td><td align="left" valign="top">.001</td><td align="left" valign="top">0.39</td><td align="left" valign="top">&#x2212;2.3 (&#x2212;4.1 to &#x2212;0.4)</td><td align="left" valign="top">.02</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="10"><bold>SDQ</bold><sup><xref ref-type="table-fn" rid="table4fn5"><bold>e</bold></xref></sup></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Total</td><td align="left" valign="top">5.4 (3.5 to 7.3)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.62</td><td align="left" valign="top">4.5 (2.4 to 6.5)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.47</td><td align="left" valign="top">&#x2212;0.9 (&#x2212;2.1 to 0.3)</td><td align="left" valign="top">.34</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Emotional</td><td align="left" valign="top">1.4 (0.7 to 2.1)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.43</td><td align="left" valign="top">0.8 (&#x2212;0.0 to 1.7)</td><td align="left" valign="top">.053</td><td align="left" valign="top">0.21</td><td align="left" valign="top">&#x2212;0.6 (&#x2212;1.1 to &#x2212;0.1)</td><td align="left" valign="top">.03</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Conduct</td><td align="left" valign="top">2.2 (1.6 to 2.8)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.78</td><td align="left" valign="top">2.1 (1.4 to 2.8)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.65</td><td align="left" valign="top">&#x2212;0.1 (&#x2212;0.7 to 0.5)</td><td align="left" valign="top">.68</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Hyperactivity</td><td align="left" valign="top">1.2 (0.5 to 2.0)</td><td align="left" valign="top">.002</td><td align="left" valign="top">0.34</td><td align="left" valign="top">1.0 (0.3 to 1.8)</td><td align="left" valign="top">.008</td><td align="left" valign="top">0.29</td><td align="left" valign="top">&#x2212;0.2 (&#x2212;0.8 to 0.3)</td><td align="left" valign="top">.44</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Peer</td><td align="left" valign="top">0.6 (0.1 to 1.0)</td><td align="left" valign="top">.02</td><td align="left" valign="top">0.25</td><td align="left" valign="top">0.6 (0.1 to 1.2)</td><td align="left" valign="top">.03</td><td align="left" valign="top">0.24</td><td align="left" valign="top">0.1 (&#x2212;0.4 to 0.6)</td><td align="left" valign="top">.77</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Prosocial<sup><xref ref-type="table-fn" rid="table4fn6">f</xref></sup></td><td align="left" valign="top">&#x2212;0.8 (&#x2212;1.4 to &#x2212;0.2)</td><td align="left" valign="top">.009</td><td align="left" valign="top">&#x2212;0.27</td><td align="left" valign="top">&#x2212;0.2 (&#x2212;0.8 to 0.4)</td><td align="left" valign="top">.45</td><td align="left" valign="top">&#x2212;0.08</td><td align="left" valign="top">0.6 (0.1 to 1.1)</td><td align="left" valign="top">.02</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Impact</td><td align="left" valign="top">1.2 (0.6 to 1.8)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.45</td><td align="left" valign="top">0.5 (&#x2212;0.2 to 1.1)</td><td align="left" valign="top">.15</td><td align="left" valign="top">0.16</td><td align="left" valign="top">&#x2212;0.7 (&#x2212;1.3 to &#x2212;0.2)</td><td align="left" valign="top">.01</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="10"><bold>ARI</bold><sup><xref ref-type="table-fn" rid="table4fn7"><bold>g</bold></xref></sup></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Irritability</td><td align="left" valign="top">3.1 (1.9 to 4.3)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.57</td><td align="left" valign="top">2.9 (1.7 to 4.1)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.52</td><td align="left" valign="top">&#x2212;0.2 (&#x2212;1.4 to 1.0)</td><td align="left" valign="top">.71</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="10"><bold>ICU</bold><sup><xref ref-type="table-fn" rid="table4fn8"><bold>h</bold></xref></sup></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Total</td><td align="left" valign="top">3.4 (0.9 to 5.9)</td><td align="left" valign="top">.008</td><td align="left" valign="top">0.30</td><td align="left" valign="top">1.7 (&#x2212;0.8 to 4.2)</td><td align="left" valign="top">.17</td><td align="left" valign="top">0.15</td><td align="left" valign="top">&#x2212;1.7 (&#x2212;3.7 to 0.4)</td><td align="left" valign="top">.11</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Callousness</td><td align="left" valign="top">1.9 (0.6 to 3.2)</td><td align="left" valign="top">.004</td><td align="left" valign="top">0.31</td><td align="left" valign="top">1.9 (0.5 to 3.4)</td><td align="left" valign="top">.008</td><td align="left" valign="top">0.29</td><td align="left" valign="top">0.0 (&#x2212;1.2 to 1.3)</td><td align="left" valign="top">.94</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Uncaring</td><td align="left" valign="top">2.0 (0.7 to 3.2)</td><td align="left" valign="top">.003</td><td align="left" valign="top">0.33</td><td align="left" valign="top">0.8 (&#x2212;0.3 to 1.8)</td><td align="left" valign="top">.17</td><td align="left" valign="top">0.15</td><td align="left" valign="top">&#x2212;1.2 (&#x2212;2.3 to &#x2212;0.2)</td><td align="left" valign="top">.03</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Unemotional</td><td align="left" valign="top">&#x2212;0.4 (&#x2212;1.0 to 0.1)</td><td align="left" valign="top">.14</td><td align="left" valign="top">&#x2212;0.16</td><td align="left" valign="top">&#x2212;0.9 (&#x2212;1.8 to 0.0)</td><td align="left" valign="top">.04</td><td align="left" valign="top">&#x2212;0.22</td><td align="left" valign="top">&#x2212;0.5 (&#x2212;1.2 to 0.2)</td><td align="left" valign="top">.14</td></tr><tr><td align="left" valign="top" colspan="11"><bold>Child&#x2019;s ability to function</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="10"><bold>Everyday situations (child behavior)</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Child behavior total</td><td align="left" valign="top">9.1 (5.3 to 12.9)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.52</td><td align="left" valign="top">8.9 (4.9 to 12.8)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.49</td><td align="left" valign="top">&#x2212;0.2 (&#x2212;3.3 to 3.0)</td><td align="left" valign="top">.91</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Transition situations</td><td align="left" valign="top">3.4 (2.0 to 4.9)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.52</td><td align="left" valign="top">2.8 (1.2 to 4.4)</td><td align="left" valign="top">.001</td><td align="left" valign="top">0.38</td><td align="left" valign="top">&#x2212;0.6 (&#x2212;1.7 to 0.5)</td><td align="left" valign="top">.27</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Dining situations</td><td align="left" valign="top">1.0 (0.2 to 1.9)</td><td align="left" valign="top">.01</td><td align="left" valign="top">0.28</td><td align="left" valign="top">1.4 (0.6 to 2.3)</td><td align="left" valign="top">.001</td><td align="left" valign="top">0.37</td><td align="left" valign="top">0.4 (&#x2212;0.4 to 1.2)</td><td align="left" valign="top">.36</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Situations outside home</td><td align="left" valign="top">2.3 (1.1 to 3.4)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.43</td><td align="left" valign="top">2.6 (1.4 to 3.7)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.49</td><td align="left" valign="top">0.3 (&#x2212;0.7 to 1.2)</td><td align="left" valign="top">.54</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Home situations</td><td align="left" valign="top">2.2 (1.1 to 3.3)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.45</td><td align="left" valign="top">2.0 (0.9 to 3.2)</td><td align="left" valign="top">.001</td><td align="left" valign="top">0.40</td><td align="left" valign="top">&#x2212;0.2 (&#x2212;1.2 to 0.9)</td><td align="left" valign="top">.73</td></tr><tr><td align="left" valign="top" colspan="11"><bold>Parental skills</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="10"><bold>Parenting Scale</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Total</td><td align="left" valign="top">0.5 (0.3 to 0.6)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.68</td><td align="left" valign="top">0.4 (0.2 to 0.5)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.49</td><td align="left" valign="top">&#x2212;0.1 (&#x2212;0.2 to 0.0)</td><td align="left" valign="top">.15</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Laxness</td><td align="left" valign="top">0.4 (0.1 to 0.6)</td><td align="left" valign="top">.002</td><td align="left" valign="top">0.35</td><td align="left" valign="top">0.3 (0.1 to 0.5)</td><td align="left" valign="top">.02</td><td align="left" valign="top">0.26</td><td align="left" valign="top">&#x2212;0.1 (&#x2212;0.4 to 0.1)</td><td align="left" valign="top">.39</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Overreactivity</td><td align="left" valign="top">0.8 (0.5 to 1.1)</td><td align="left" valign="top">&#x003C;.001</td><td align="left" valign="top">0.59</td><td align="left" valign="top">0.6 (0.3 to 0.9)</td><td align="left" valign="top">.001</td><td align="left" valign="top">0.41</td><td align="left" valign="top">&#x2212;0.2 (&#x2212;0.4 to 0.1)</td><td align="left" valign="top">.09</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Hostility</td><td align="left" valign="top">0.2 (0.0 to 0.3)</td><td align="left" valign="top">.01</td><td align="left" valign="top">0.28</td><td align="left" valign="top">&#x2212;0.0 (&#x2212;0.3 to 0.2)</td><td align="left" valign="top">.70</td><td align="left" valign="top">&#x2212;0.04</td><td align="left" valign="top">&#x2212;0.2 (&#x2212;0.5 to &#x2212;0.0)</td><td align="left" valign="top">.03</td></tr><tr><td align="left" valign="top" colspan="11"><bold>Parental mental health</bold></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top" colspan="10"><bold>DASS-21</bold><sup><xref ref-type="table-fn" rid="table4fn9"><bold>i</bold></xref></sup></td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Total</td><td align="left" valign="top">4.0 (&#x2212;0.8 to 8.9)</td><td align="left" valign="top">.10</td><td align="left" valign="top">0.18</td><td align="left" valign="top">0.9 (&#x2212;4.2 to 5.9)</td><td align="left" valign="top">.73</td><td align="left" valign="top">0.04</td><td align="left" valign="top">&#x2212;3.2 (&#x2212;8.3 to 1.9)</td><td align="left" valign="top">.22</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Depression</td><td align="left" valign="top">1.5 (&#x2212;0.7 to 3.8)</td><td align="left" valign="top">.17</td><td align="left" valign="top">0.15</td><td align="left" valign="top">0.6 (&#x2212;1.4 to 2.6)</td><td align="left" valign="top">.57</td><td align="left" valign="top">0.06</td><td align="left" valign="top">&#x2212;1.0 (&#x2212;2.8 to 0.8)</td><td align="left" valign="top">.29</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Anxiety</td><td align="left" valign="top">&#x2212;0.2 (&#x2212;1.7 to 1.2)</td><td align="left" valign="top">.74</td><td align="left" valign="top">0.04</td><td align="left" valign="top">&#x2212;0.7 (&#x2212;2.7 to 1.2)</td><td align="left" valign="top">.45</td><td align="left" valign="top">0.08</td><td align="left" valign="top">&#x2212;0.5 (&#x2212;2.0 to 1.0)</td><td align="left" valign="top">.51</td></tr><tr><td align="left" valign="top"/><td align="left" valign="top"/><td align="left" valign="top">Stress</td><td align="left" valign="top">2.9 (0.7 to 5.0)</td><td align="left" valign="top">.009</td><td align="left" valign="top">0.29</td><td align="left" valign="top">1.0 (&#x2212;1.1 to 3.2)</td><td align="left" valign="top">.34</td><td align="left" valign="top">0.10</td><td align="left" valign="top">&#x2212;1.9 (&#x2212;4.3 to 0.6)</td><td align="left" valign="top">.14</td></tr></tbody></table><table-wrap-foot><fn id="table4fn1"><p><sup>a</sup>Measurement before the program started.</p></fn><fn id="table4fn2"><p><sup>b</sup>Measurement at 12 months after the program started.</p></fn><fn id="table4fn3"><p><sup>c</sup>Measurement at 24 months after the program started.</p></fn><fn id="table4fn4"><p><sup>d</sup>CBCL/1.5&#x2010;5: Child Behavior Checklist for preschool children.</p></fn><fn id="table4fn5"><p><sup>e</sup>SDQ: Strengths and Difficulties Questionnaire.</p></fn><fn id="table4fn6"><p><sup>f</sup>Increase in prosocial SDQ subscore indicates improvement.</p></fn><fn id="table4fn7"><p><sup>g</sup>ARI: Affective Reactivity Index.</p></fn><fn id="table4fn8"><p><sup>h</sup>ICU: Inventory of Callous-Unemotional Traits.</p></fn><fn id="table4fn9"><p><sup>i</sup>DASS-21: 21-item Depression, Anxiety, and Stress Scale.</p></fn></table-wrap-foot></table-wrap><p>We conducted an additional analysis of 37 (74%) of the 50 parents who completed the SDQ questionnaire both at baseline and at the 24-month follow-up as well as the parent training program. This analysis showed that 30 (81%) of the 37 children had a total SDQ score above the 90th percentile (ie, abnormal range) at baseline, while only 14 (38%) remained in the abnormal range at the 24-month follow-up (<italic>P</italic>&#x003C;.001, McNemar test), based on the population sample of 4&#x2010; to 16-year-old children [<xref ref-type="bibr" rid="ref12">12</xref>]. To examine the children in the proximity of cutoff thresholds, we also used the 80th percentile cutoff point (ie, abnormal or border range), which showed that 36 (97%) children were above the cutoff point at baseline, while the respective figure at the 24-month follow-up was 23 (62%), indicating a highly significant change (<italic>P</italic>&#x003C;.001, McNemar test).</p><p>When parents were asked about perceived difficulties regarding their child&#x2019;s behavior problems with a single question&#x2014;&#x201C;Overall, do you think that your child has difficulties in 1 or more of the following areas: emotions, behavior, or being able to get on with other people?&#x201D;&#x2014;at baseline, 2 (5%) of 37 had no or minor problems, 20 (54%) had definite problems, and 15 (41%) had severe problems. The respective figures at the 24-month follow-up were 14 (38%), 14 (38%), and 9 (24%; <italic>P</italic>=.001, McNemar-Bowker test).</p><p>Among the child psychometric measures, callousness and uncaring improved between baseline and the 12-month follow-up. However, uncaring deteriorated between the 12- and 24-month follow-up, and no significant improvement was found between baseline and 24 months. The SFSW parent training program did not have any significant positive association with unemotional traits at the 12- or 24-month follow-up.</p><p>Child functioning in everyday situations (eg, transitions, dining, and home and outside home activities) improved significantly between baseline and both follow-up points. No significant change was observed between the 12- and 24-month follow-up comparisons.</p><p>Interestingly, there were differences between parenting styles regarding the long-term changes. Parental overreactivity and laxness improved between baseline and the 12-month follow-up and between baseline and the 24-month follow-up. Parental hostility showed improvement between baseline and the 12-month follow-up but not between baseline and the 24-month comparison. In fact, hostility showed significant deterioration between the 12- and 24-month follow-up. We observed no significant association in parental mental health problems, measured with a 21-item Depression, Anxiety, and Stress Scale, between baseline and either of the follow-ups.</p><p>Finally, to graphically illustrate the key findings, <xref ref-type="fig" rid="figure1">Figure 1A-D</xref> describes the changes of main outcome measures across time points including posttreatment and at the 6-month follow-up, which has previously been reported in detail [<xref ref-type="bibr" rid="ref12">12</xref>]. Of note, the PS and ICU were not measured at posttreatment. The figures illustrate that SDQ conduct and ARI irritability scores exhibited the largest improvement between baseline and posttreatment and further improvement between posttreatment and the 6-month follow-up; the findings at the 12- and 24-month follow-ups were rather stable. Among the ICU measures, callousness and uncaring showed improvement between baseline and the 6-month follow-up. After that, callousness stayed quite stable, while uncaring and unemotional showed deterioration. As for the parenting measures, all parenting styles showed improvement between baseline and the 6-month follow-up. After that, overreactivity and laxness were quite stable, while hostility showed deterioration.</p><fig position="float" id="figure1"><label>Figure 1.</label><caption><p>(A-D) Mean curves of SDQ conduct scores, irritability scores, ICU scores, and Parenting Scale subscores. (A) SDQ conduct scores over time (model-based least-squares means, SE). (B) Irritability scores over time (model-based least-squares means, SE). (C) ICU subscales over time (model-based least-squares means, SE). (D) Parenting Scale subscores over time (model-based least-squares means, SE). ICU: Inventory of Callous-Unemotional Traits; SDQ: Strengths and Difficulties Questionnaire.</p></caption><graphic alt-version="no" mimetype="image" position="float" xlink:type="simple" xlink:href="pediatrics_v7i1e63416_fig01.png"/></fig></sec></sec><sec id="s4" sec-type="discussion"><title>Discussion</title><sec id="s4-1"><title>Principal Findings</title><p>To the best of our knowledge, this is the first study on long-term follow-up of digital-guided parent training intervention among children referred to treatment from specialized care. The findings mostly complement the previously conducted 6-month follow-up study [<xref ref-type="bibr" rid="ref12">12</xref>] by showing that the SFSW program was associated with significant improvements in children&#x2019;s externalizing symptoms (our primary outcome) at 12 and 24 months after baseline. Of note, most of the improvement took place between baseline and posttreatment assessment, and the level of externalizing problems showed stability from the 12- to the 24-month follow-up. This study&#x2019;s importance is in demonstrating that digital parent training with weekly remote phone coaching seems to lead to enduring improvements in disruptive behavior problems in children with severe disruptive behavior problems. The findings align with a 24-month follow-up study of the SFSW program [<xref ref-type="bibr" rid="ref11">11</xref>,<xref ref-type="bibr" rid="ref15">15</xref>-<xref ref-type="bibr" rid="ref17">17</xref>], which was used as a preventive and early intervention among 4-year-old children, identified through national medical checkups [<xref ref-type="bibr" rid="ref28">28</xref>]. However, since the target group was different, the level of disruptive behavior problems among the children in this study was much more severe [<xref ref-type="bibr" rid="ref12">12</xref>], which suggests the promise of such interventions in supporting populations with different levels of symptom severity.</p><p>Most comorbidities such as hyperactivity, emotional and peer problems, and child functioning in everyday situations maintained their improvement from baseline to the 12- and 24-month follow-ups as well. Interestingly, the program seemed to have a very clear association with decreased irritability. This novel finding implies that some of the major effects of parent training may be associated with decreasing irritability in parent-child interactions; this requires further research.</p><p>For some problems, such as callous-unemotional traits, improvement was reported at the 12-month follow-up but not at the 24-month follow-up. Callous-unemotional traits characterize a specific subgroup of children exhibiting early starting, stable, and severe conduct problems. It has been argued that conventional parenting interventions frequently prove ineffective within this subgroup [<xref ref-type="bibr" rid="ref29">29</xref>,<xref ref-type="bibr" rid="ref30">30</xref>].</p><p>Another important finding was that the responses to the parent training program seemed to differ according to parenting styles. Improvements in parent overreactivity and laxness were shown both in the comparison between baseline and the 12- and 24-month follow-ups, while parental hostility improved until the 12-month follow-up, then deteriorated to the same level as at baseline. It could be interpreted that parental hostility is, in the long run, resistant to parent training programs. It is also possible that accumulated stressors during the COVID-19&#x2013;related public health restrictions may have posed an additional strain on some parents&#x2019; psychological resources [<xref ref-type="bibr" rid="ref31">31</xref>-<xref ref-type="bibr" rid="ref33">33</xref>] and on their ability to maintain positive approaches to their child.</p><p>There is limited research on the effects of parenting interventions on reducing parental hostility. Parental hostility can have broad impacts within the family, potentially disrupting the ability of one parent to maintain a positive relationship with their child [<xref ref-type="bibr" rid="ref34">34</xref>]. There is a significant positive correlation between parent hostility and child aggression, indicating that the more hostile parents are toward others, the more aggressive their children tend to be [<xref ref-type="bibr" rid="ref35">35</xref>]. Similar findings regarding conduct problems, callous-unemotional traits, and parenting were made in a previous study [<xref ref-type="bibr" rid="ref36">36</xref>], where higher levels of parental harshness were related to higher levels of child conduct problems and callous-unemotional traits. Children subjected to abuse resulting from their parents&#x2019; aggressive behavior may experience adverse effects on their self-control and exhibit challenges in impulse control by acting impulsively, speaking before thinking, and demonstrating a reduced capacity to tolerate frustration or cope with failure [<xref ref-type="bibr" rid="ref37">37</xref>]. There are also findings showing that parental attitudes play a substantial role in the gradual enhancement of a child&#x2019;s self-control, exerting a significant impact on the individual [<xref ref-type="bibr" rid="ref35">35</xref>]. In cases where parent training proves to be ineffective in the long term in reducing parental hostility, the parent could benefit from receiving personal support or therapy to address this issue. It is likely that more tailor-made and targeted interventions and treatment plans would benefit this subgroup of families, which are at risk of falling into this kind of negative cycle.</p><p>When the study started in May 2020, Helsinki was grappling with the peak of the COVID-19 pandemic, marked by a state of emergency declared nationwide in Finland. Stringent social distancing measures were enforced in the region to curb the virus&#x2019;s transmission, significantly affecting families residing in the area. The COVID-19 pandemic has highlighted the importance of exploring remote, digital, or digitally assisted solutions for ensuring that young children, and their families, are provided with prompt support for mental health problems. This study demonstrated that technology can provide effective alternatives to traditional face-to-face interventions and can overcome a number of barriers during crises. Technology can be used to provide the right treatment at the right time, with high levels of support and fidelity, providing greater access and convenience and requiring fewer costs and less time.</p></sec><sec id="s4-2"><title>Limitations</title><p>It is important to acknowledge certain limitations. The present results from our clinical sample do not necessarily generalize across community samples. Since no a priori power analysis was performed, we cannot exclude the possibility that the study was underpowered. We note that with a sample size of 50 participants, we had 80% power to detect an effect size of 0.35 (1-tailed, &#x03B1;=.05). The study design did not allow for direct conclusions regarding the program&#x2019;s efficacy, as it lacked an intervention-control group design. However, the COVID-19 pandemic meant that treatment and family counseling services could not be provided in the usual way, and conducting a randomized controlled study design would have been considered ethically inappropriate. Due to the lack of a control group, it is not possible to exclude the possibility of some age-related spontaneous improvement reflected in the results. Nevertheless, an earlier RCT using population-based screening in Finland showed that the SFSW intervention was effective at 2-year follow-up [<xref ref-type="bibr" rid="ref11">11</xref>]. Furthermore, the constraints of social distancing, which included school closures, also prevented us from conducting direct observations of parenting, clinical assessments, and teacher ratings. It is possible that some consequences of those restraints are also reflected in some of our measures, such as the SDQ prosocial and peer subscales.</p></sec><sec id="s4-3"><title>Conclusions</title><p>This study provides support for the utility of remotely delivered parent training interventions. Incorporating remote interventions into child mental health services also serves as a safeguard during crisis situations such as COVID-19.</p><p>The study shows that remote digital child mental health services bring substantial benefits to families that can last for up to 2 years. Overall, the study emphasizes that guided digital parent training programs can be a crucial component in developing evidence-based treatment practices for children and families.</p><p>The study also emphasizes the importance of conducting long-term follow-ups to understand long-term intervention gains. The study results indicate that different parenting profiles and child psychopathology may have varying effects on the long-term outcome of the program. This finding is important when developing personalized parenting interventions for increased impact.</p></sec></sec></body><back><ack><p>The authors extend their gratitude to the head of Helsinki Family Counselling Centers, Leena Lehikoinen, and all the other professionals from the family counseling centers in Helsinki who contributed to making this study possible. This project has received funding from the European Research Council under the European Union&#x2019;s Horizon 2020 research and innovation program (grant agreement 101020767) and from the Research Council of Finland (decision 345546).</p></ack><fn-group><fn fn-type="conflict"><p>AS is the founder and director of Digifamilies, a provider of evidence-based treatments to Finnish public health services. AB received grant funding from The Israel National Institute for Health Policy Research, the National Institutes of Health, and the Israeli Scientific Foundation. He also provides consultancy services to ifeel. The remaining authors have no conflicts of interest to disclose.</p></fn></fn-group><glossary><title>Abbreviations</title><def-list><def-item><term id="abb1">ARI</term><def><p>Affective Reactivity Index</p></def></def-item><def-item><term id="abb2">CBCL</term><def><p>Child Behavior Checklist</p></def></def-item><def-item><term id="abb3">ICU</term><def><p>Inventory of Callous-Unemotional Traits</p></def></def-item><def-item><term id="abb4">PS</term><def><p>Parenting Scale</p></def></def-item><def-item><term id="abb5">RCT</term><def><p>randomized controlled trial</p></def></def-item><def-item><term id="abb6">SDQ</term><def><p>Strengths and Difficulties Questionnaire</p></def></def-item><def-item><term id="abb7">SFSW</term><def><p>Strongest Families Smart Website</p></def></def-item></def-list></glossary><ref-list><title>References</title><ref id="ref1"><label>1</label><nlm-citation citation-type="journal"><person-group person-group-type="author"><name 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