Human papillomavirus (HPV) causes 34,800 anogenital and oropharyngeal cancer cases in the United States annually [1]. To prevent these cancer cases, the HPV vaccine is recommended for children aged 11-12 years. Additionally, unvaccinated persons can receive catch-up vaccination until the age of 26 years or participate in shared decision-making with a provider until the age of 45 years [2]. Despite this evidence-based recommendation, the rate of HPV vaccination is suboptimal. Healthy People 2030 aims to achieve a rate of 80% HPV vaccination coverage for adolescents [3], and although gains have been steady over the years, only 58.6% were up to date as of 2020 [4].

Parental exposure to health information on the internet and social media platforms may influence HPV vaccine awareness, decisions, and uptake. Most parents use the internet to search for information regarding their child’s health, especially to help prepare for questions when seeing a doctor [5]. In a study on Google searches related to preventable infectious diseases, looking for vaccine information generally was not prevalent; however, the HPV vaccine was the exception [6]. Thus, exposure to web-based content regarding HPV vaccination may be common for some parents prior to discussing with health care providers. Furthermore, a North Carolina study found that parents who learned of the HPV vaccine on the internet were more willing to get their daughters vaccinated [7]. Similarly, adult internet users were more likely to be aware of the HPV vaccine compared to noninternet users [8].

Despite being a source of factual information regarding HPV vaccination, social media and internet sources can increase exposure to misinformation (ie, false information aiming to deceive the reader [9]). From 2014-2017, Twitter bots (ie, Twitter accounts that are automated to post content and create impressions) were used to spread vaccine misinformation on social media platforms [10]. HPV vaccine content on social media is often user-generated [11] and includes positive (in favor of vaccines) and negative (against vaccines) messages [12-18], which can mean that parents, children, and adolescents are exposed to a variety of content on social media—some of which is not credible.

Health literacy and internet verification skills may improve information seeking and help counteract the spread of misinformation. Health literacy refers to how a person accesses, understands, appraises, and uses health information [19]. Internet verification skills may assist in identifying the veracity of information [19]. Given the expansive amounts of misinformation and negative information about vaccines on social media [20], especially on HPV vaccination [13,17], internet verification skills assessing content and source may help individuals better distinguish between credible and noncredible sources. Developing strategies to combat misinformation and increase confidence in the HPV vaccine via social media is a goal for HPV vaccine–related research [21]. In this study, we examined the association between parents’ perceptions of HPV vaccine information on social media and internet verification strategies used with the HPV vaccine decision-making stage for their child.

Prior to entering a physician’s office, parents may be exposed to information on HPV vaccination via the internet and social media. Although some information may be useful for informed decision-making on HPV vaccination, misinformation also exists [17]. This study explored how internet verification skills and perceptions of HPV vaccine information on social media relate to HPV vaccination and decision-making among parents of children and adolescents. Overall, we found that parents’ trust in providers, perceptions of HPV vaccine information credibility on social media, reporting that social media information makes one question HPV, and internet verification skills were related to not wanting HPV vaccination for their child. The parent’s gender, younger age of the child, and prompts for questioning HPV vaccination based on social media information were related to wanting the vaccine.

Parents of vaccinated children and adolescents reported performing more internet verification behaviors compared to parents in the unvaccinated and unwanted group. These behaviors included checking that the website is up to date and has a credible author and cross-checking with other sources. Our finding may explain why parents with a vaccinated child do not question information they see on social media, because they have the internet verification skills to filter through misinformation. Previous research has found that parents desire guidance on how to search and assess the reliability of information found on the internet [5]. Empowering parents with health literacy skills to filter health information on the internet, particularly related to vaccines, may be an important strategy to promote positive attitudes and intentions toward vaccination and, ultimately, HPV vaccine uptake.

Overall, many people find it difficult to distinguish credible and noncredible information sources [25]; however, this finding may be changing with exposure to more information on the vaccine development process with COVID-19 vaccines. The field needs to examine how COVID-19 vaccine–specific attitudes influence the attitudes and uptake of other vaccines. For example, parents with fewer internet verification skills may question the HPV vaccine more given the COVID-19 media coverage, which could result in additional questioning when discussing the HPV vaccine with providers [26]. The ubiquitous nature of social media results in high exposure to potential misinformation, which may increase parental hesitancy and potentially frustrate health care providers due to the challenges associated with managing patient concerns from social media sources. To encourage vaccination, providers must attend to parents’ concerns in a nonconfrontational and nonjudgmental manner with parents who question vaccines [26].

Provider recommendation and discussion are imperative to HPV vaccine initiation and completion among adolescents [27,28]. Although provider-patient communication is a component of most medical education curricula, some providers express low confidence in their ability to influence parents regarding vaccination [29]. In a recent study, about a third of providers reported that over 10% of parents of adolescents in their practice expressed HPV vaccine hesitancy, whereas over 50% of pediatricians in the same study did not feel confident responding to parents’ misinformation obtained from the internet/social media or the news [30]. The quality of provider recommendations has consistently predicted HPV vaccine initiation and completion, and multiple interventions to educate providers on reliable techniques (patient reminders, presumptive recommendation, and reference to HPV vaccination as cancer prevention) are available to support providers and reinforce vaccine communication skills [31,32].

Perceptions of credibility of social media HPV vaccination information is relevant for parents’ HPV vaccine decisions. Specifically, parents who did not believe that the information they saw on social media is credible were more likely to not want the vaccine. This finding may be attributed to the types of information parents are exposed to on social media. Although information on HPV vaccination on the internet is both positive and negative [17], social media algorithms and social networks may bias the types of information parents are exposed to so that it aligns with their beliefs. As such, additional research is needed to explore how an individual’s beliefs, health literacy skills, and information-seeking behaviors intersect with community and group norms driven by social media platforms. Moreover, researchers should test novel interventions that adapt messaging in real time based on evolving social media content; recent advances in artificial intelligence and machine learning are potential avenues moving forward. However, previous research has found that tools, such as web-based smart assistants, do not always provide credible HPV vaccine information [33]. There is also evidence that combatting misinformation in a “myth-versus-fact” format tends to backfire and reinforce the preexisting belief in the myth [34,35].

Similarly, parents who did not want the HPV vaccine were less likely to question the vaccine based on exposure to information on social media than the vaccinated group. In contrast, parents who wanted their child vaccinated were less likely to think the information on social media makes them question the HPV vaccine than parents with a vaccinated child. Thus, persons who do not intend to vaccinate their child for HPV may already be exposed to information that confirms their beliefs on vaccination, whereas persons who intend to vaccinate their children may not have enough information to transition to the vaccine decision-making stage. Social media users on Facebook and Twitter are likely to be exposed to like-minded posts via the echo chamber effect [36]. For example, parents with a vaccinated child could have been exposed to more pro-vaccine messages, which could heighten perceptions of credibility and lead to vaccination behaviors. Additional longitudinal studies are needed to examine the temporality of the types of information exposure on the internet/social media and future vaccine behavior. Moreover, as social media is used to share information, developing novel strategies to combat misinformation on various platforms is urgently needed. Promoting evidence-based information on vaccination on the internet and social media via trusted messengers, such as providers, may be an effective approach compared to the removal and censorship of anti-vaccine content alone [37]. Given that not all persons engage in internet verification skills when consuming health information, providers and other trusted messengers, such as other parents [38], could be an accurate dissemination channel on social media and the internet. This process would require the development of social media strategies to reach intended audiences and relying on algorithms so that the content is more prominent in search results and social media feeds. However, a recent study found that anti-vaccine social media posts are associated with increases in mothers’ general vaccine hesitancy and decreases in their children’s HPV vaccination rates, whereas pro-vaccine content were not associated with hesitancy nor vaccination rates [39]. As a whole, the literature on social media and HPV vaccination is in its infancy, and a recent systematic review by Ortiz et al [40] recommends more rigorous and systematic research.

Finally, another key finding was that parents who did not want their child vaccinated for HPV were more likely to distrust providers than parents who vaccinated their child. Taken in context with other study findings, the parents who do not want their child vaccinated may be going to social media to corroborate their beliefs or are exposed to misinformation on the internet contributing to their beliefs. Studies are needed to experimentally test how exposure to misinformation and correct information on social media influences decisions for vaccination, and how and who is best to intervene in this evolving setting. Ultimately, a segmented approach to vaccine information dissemination is needed to reach different parental groups on the hesitancy spectrum.

These findings should be recognized in the context of study limitations. First, this study was cross-sectional, and we could not assess the temporality between exposure to information on social media, internet verification skills, and the vaccine decision-making stage. As such, respondents may have adopted attitudes that align with their current behavior to reduce cognitive dissonance. Second, these data were derived from a sample in North Texas and may not be generalizable to other US regions. Additionally, HPV vaccination status was self-reported, and misclassification bias for the outcome variable may be present. Finally, these data were collected prior to the COVID-19 pandemic, and perceptions regarding social media and credibility may have shifted. Internet verification skills and strategies, however, could similarly impact COVID-19 vaccine decision-making. These findings could be relevant to apply toward vaccine hesitancy studies about COVID-19.

Although many strategies to promote HPV vaccination have focused on the provider recommendation during a visit, extensive exposure to social media before a visit may inform parents’ beliefs and attitudes toward HPV vaccination and, ultimately, their decision to vaccinate their child. Thus, interventions that promote web-based health literacy skills are needed so that parents can make informed health care decisions with their providers. Social media will remain an ongoing obstacle to evidence-based health information, and public health responses must adapt to this challenge accordingly.