BMC is a 950-bed consultant hospital located in Mwanza, Tanzania. It is one of the three cancer treatment centers in the country, and the only oncology referral center for the Lake Zone of Tanzania. BMC reports more than 200 newly diagnosed pediatric cancer cases each year [8].

In July 2017, a cross-sectional survey was conducted among a purposive sample of caregivers of children aged <18 years who were diagnosed with cancer at BMC. All caregivers who were seen in either the inpatient or outpatient setting during the study period were approached for participation in the study. Only one caregiver per patient completed a survey. Informed consent and survey completion was done in either Swahili or English, based on the participant’s language preference. Adult participants provided written informed consent. For participants who self-identified as unable to read, we obtained verbal consent with thumbprint in the presence of a literate witness per institutional standards.

A 26-question survey instrument to elicit descriptive data on patterns of mobile phone ownership and use was previously developed, translated into Swahili, and pilot-tested in the Tanzanian population [17]. Survey domains include mobile phone ownership, technology literacy, and perceived acceptability for digital health interventions. In this study, the section on intervention acceptance was further tailored to include specific pediatric cancer use cases. Participants independently completed the survey. For those who self-identified as unable to read, a patient navigator read the questionnaire aloud and recorded the responses from the caregiver. Surveys were completed in a private room to ensure confidentiality of responses. All surveys were completed on paper, and the responses were stored in a secured office at BMC.

Statistical analysis was conducted using Excel (version 16; Microsoft Corporation). Descriptive statistics were generated from the survey data using mean and SD values for continuous variables and percentages for binary or categorical variables.

The study was reviewed and approved by the National Institute for Medical Research in Tanzania (NIMR/HQ/R.8a/Vol. IX/3096), the Ethics Committee at BMC (CREC/292/2018), and Duke University Center Institutional Review Board (PRO00094010).

All eligible caregivers who were approached (N=40) agreed to participate in the study. Survey findings related to mobile phone ownership and use are described in Table 1.

Of the 40 participating caregivers, the majority (n=34, 85%) reported mobile phone use. Of these, 97% (33/34) owned mobile phones, and 3% (1/34) reported their spouse as the primary owner of the mobile phone. Most caregivers (31/34, 91%) owned mobile phones that did not have smartphone capabilities. Vodacom and Airtel were the two most used cellular networks, reported by 76% (26/34) and 65% (22/34) of respondents, respectively.

We assessed survey respondents’ technology literacy pertaining to their mobile devices (Table 2). All caregivers with mobile phones reported being able to receive phone calls. A majority of respondents reported being able to view and read a text message (25/34, 74%), but fewer participants reported being able to compose text messages. About 1 in 2 caregivers (18/34, 53%) knew how to take and send a picture via a cell phone, and 47% (16/34) knew how to watch videos.

Caregiver responses to the utility of implementing mobile technology in the treatment of pediatric cancer therapy at BMC are illustrated in Figure 1. Of the 40 caregivers, 98% (n=39) thought using mobile technology to communicate with providers would be useful, 95% (n=38) wanted to use mobile technology to receive reminders regarding upcoming appointments, and 88% (n=35) wanted to receive education material and information. Over half (23/40, 58%) of all respondents answered an additional open-ended free-text response question asking what other benefits mobile technology could have in the treatment for their child. Of those, the majority (22/23, 96%) of respondents focused their answer on the potential use of mobile technology to communicate with a medical provider in a time of emergency (ie, febrile illness or severe nausea or vomiting).

mHealth interventions have soared in recent history, with over 500 projects implemented in sub-Saharan Africa in the last decade [18-20]. This proliferation of mHealth interventions is due in part to the rapid expansion of mobile phone use and infrastructure worldwide [21]. The majority of caregivers surveyed at BMC owned and used mobile phones and were interested in using these devices to learn and communicate about their child’s cancer treatment. These findings support high feasibility and acceptability for mHealth strategies at BMC to provide targeted information and communication to caregivers of children with cancer, while reducing burden on limited health care resources and personnel. However, additional studies will be needed to confirm the feasibility and acceptability of any future mHealth interventions that are developed for caregivers.

In this study, the proportion of caregivers who reported using a mobile phone (85%) was similar to the national mobile phone subscription rate in Tanzania (82%) [13]. In sub-Saharan Africa, data plans are often inexpensive, and their use is widespread regardless of socioeconomic status [22,23]. Furthermore, investments in mobile phone infrastructure have led to an estimated 93.7% cell tower coverage nationwide, suggesting that an intervention delivered by mobile phone has a high potential reach in Tanzania [24].

Although access to cell coverage is high, many caregivers reported using multiple SIMs with different cellular carriers. Having multiple SIM cards may be a barrier to implementing interventions since other studies have reported challenges with reaching participants when an alternate SIM is in use [25]. However, in Tanzania, mobile phone owners maintain the same telephone number when they switch networks, as part of the Mobile Number Portability Act [26,27]. The high rate of mobile phone ownership and flexibility between networks in Tanzania are important in establishing consistent communication between patients and providers. Our results reveal that the most effective delivery method of content to caregivers in our study setting was via phone calls, as 97% to 100% of respondents that used a mobile phone were capable of making or receiving a phone call.

Although text messaging is a cheaper alternative to voice-based communication in Tanzania, our findings suggest low literacy among caregivers to support a text messaging intervention. We found that text messaging would not be as effective, as only 74% could read a text message and 65% of respondents could send a text message. When faced with the challenges of low literacy rates, Wazazi Nipendeni, a text messaging app for pregnant women in Tanzania, added supporters and voice-based technology to read the text messages [21,28]. However, in many LMICs, including Tanzania, there is perceived community stigmatization related to pediatric cancer, and having someone other than an immediate family member read or verbalize messages may exacerbate the existing barriers to cancer diagnosis and treatment. Therefore, further research is needed to understand the acceptability of using family or community supporters for childhood cancer and whether community-based cancer stigma poses barriers to such a strategy.

In our study, we surveyed caregivers directly to assess their perspectives on the value of a mobile phone–based intervention. Our data suggest high acceptability and desire among caregivers to use mobile phones to communicate with providers, receive lab and appointment reminders, and view educational material related to their child’s cancer diagnosis. An important point to note is that almost all respondents who answered the free-text question regarding other uses of a digital case management system requested a hotline number they could contact in the event of an emergency. Currently, there are no systems in place for a caregiver to contact a trained oncology provider at BMC, and this is likely the situation in other LMIC settings as well. Including end-user participants in the creation and implementation of technologies increases adoption of the intervention, and the idea of using patient-centered feedback in mHealth systems has been a diverging point between successful and unsuccessful implementations [29]. Our results support this claim, as our user-centric approach identified the need of a direct pathway for caregivers to access information from medical providers about their child’s diagnosis and treatment. Including this information in the implementation of future digital platforms will allow us to better care for patients.

Our study sought to evaluate caregiver acceptability of mobile phone use in the global pediatric oncology setting. Of all the initiatives in the 2014 African Strategies for Health mHealth Compendiums, only one focuses on cancer—mEPOC, an app that provides early detection and prevention of oral cancers. There have not been other reports of mHealth in global pediatric oncology [30]. Therefore, this represents an area of need in LMICs, as supporting caregivers of patients with cancer is known to have a positive impact on parent distress and treatment outcomes in HICs [31,32].

This study has several limitations. First, although the survey was previously translated to Swahili and adapted for use in Tanzania, the transcultural adaptation was done for the southern region of Tanzania, whereas our study was completed in the Northeast region of the country, potentially limiting its generalizability [17]. However, the Swahili language used in Tanzania is the same throughout the country, and the domain questions selected used concrete concepts (ie, if the respondent owned a mobile phone), for which regional variations in interpretation would be unlikely. Second, due to the small sample size, we were unable to conduct advanced statistical analyses to assess associations between caregiver characteristics and acceptability. Future planned studies could provide an in-depth assessment of caregiver acceptance by recruiting a larger sample of respondents. Nonetheless, our data suggests that an mHealth intervention at the pediatric cancer department of BMC would be used by caregivers and that it could decrease treatment abandonment via improved communication with providers and patients, clinic reminders, education, and a hotline for emergencies. Given geographical barriers to care in certain parts of Tanzania, especially in rural settings where traveling to health facilities may entail significant time and financial burden, a medical emergency hotline could be of significant benefit for caregivers. Our high rates of population mobile phone use, feasibility, and acceptability of mobile phone intervention delivery are consistent with other chronic disease mHealth research [33]. With cancer being one of the major causes of death from noncommunicable diseases, and with the number of new cases of pediatric cancers rising, it is imperative that we build the evidence base for patient-facing mHealth interventions in this field.