Globally, asthma is the most common chronic illness affecting children [1-3] and can have serious health consequences. It is one of the key causes of urgent hospital admissions and morbidity in children [3,4]. This is a particularly urgent problem in the United Kingdom. Out of all the Organization for Economic Co-operation and Development countries, the United Kingdom has the third highest risk of death because of pediatric asthma [3,4]. Although specific data are not available for many countries, asthma has high costs worldwide [5]. The variation in mortality across countries suggests that many of the negative outcomes of childhood asthma, for patients and health care systems, are potentially avoidable [6]. Effective management programs are likely to be a cost-effective means of improving asthma control and reducing the economic burden across countries by enabling early and preventive measures to be taken [5].

A growing number of digital technologies are being developed to help the self-management of people with asthma [7-9]. Broadly, digital technologies are electronic systems that can collect, analyze, and share data, and common examples include mobile or web apps, smart devices, and other phone or internet-based interventions. Some evidence suggests that digital interventions can help support asthma health management, particularly by improving medication adherence [10,11]. However, other results, particularly in terms of effectiveness (depending on the outcome examined) [9] and app quality [8], are mixed. Research has also identified limitations in the studies examining these interventions, including inadequate descriptions of digital interventions, a lack of economic analyses, and small sample sizes [10,12].

For digital interventions to be effective, people need to be willing to use them. Although digital interventions have been shown to be generally acceptable to a wider population [11], special consideration is needed when evaluating digital interventions for children and young people. Adolescents are a particularly challenging group to treat, and poor health literacy and self-management skills can affect their treatment adherence and health outcomes [2]. Attitudes toward electronic monitoring devices were found to be mixed in adolescents, depending on how they perceived the intervention [13]. Among those who viewed asthma as a serious threat, the monitoring device was viewed as reassuring. However, many adolescents were suspicious of the device, reporting concerns that it would get them in trouble if they did not adhere properly to their medication and beliefs that their health care providers did not trust them to take the medication [13]. This demonstrates the need to examine digital interventions tailored specifically for children and young people, as their needs and responses to the interventions may not be the same as the general population.

Although several systematic reviews have examined various topics related to digital interventions for asthma management, there is a need for a comprehensive overview of the evidence being gathered to assess the effectiveness of various types of digital interventions for children and young people with asthma. No previous reviews have been identified that are specific to this population but are broad in terms of the digital interventions examined.

Of the systematic reviews that have focused specifically on children and young people, the scope was limited with respect to either outcome (eg, a focus on treatment adherence [14]) or type of digital technology (eg, only mobile apps [10] or smart devices [15]). One review provided a comprehensive assessment of other systematic reviews [12]. However, this review was published in 2014; given the rapid evolution of digital technology [16], the state of the field has changed since the review was conducted. For instance, electronic inhaler monitoring is a relatively new development [17,18], with smart inhalers only recently becoming commercially available [19]. Another review analyzed studies of children with a wide range of outcomes—adherence, health outcomes, and user perceptions—but only searched PubMed and Embase databases for the study, which raises the concern that some relevant studies might have been missed [9]. To determine if any relevant reviews were in progress, PROSPERO was searched using several combinations of keywords (asthma AND child OR paediatric OR pediatric AND digital OR technology OR mHealth OR eHealth). These searches identified one relevant registration: a review that was planned, but not executed, by academics associated with the current research team [20].

No reviews were found that examined how the technologies are integrated into current clinical care pathways for children and adolescents with asthma. This is an important area to examine because digital technologies can provide health care professionals with a large body of information that enables them to personalize asthma care plans and focus on preventive measures [21]. A small study by American physicians identified a mix of perceived benefits, barriers, and concerns about integrating digital technologies in asthma care for adolescents [22]. Further research is needed into how digital interventions are currently integrated with health care services [21], to inform the development of integrated clinical care pathways. An overview of the different types of digital technologies and the different ways they are being integrated with health care systems will help inform the development of effective, technologically enhanced care pathways for children with asthma.

The primary objectives of the scoping review are to assess and summarize the current state of the literature on digitally enhanced asthma care for young people and identify any gaps [23]. Three research questions were developed to focus on the review:

The review was structured following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR; Multimedia Appendix 1) [24], and the search strategy was developed using the Population, Intervention, Comparator, Outcome, and Study framework (Textbox 1). No protocol was registered or published for this review. A preliminary review of the literature was conducted to extract Medical Subject Headings (MeSH) terms and keywords for the search. The search was performed in five databases (PubMed, the Cochrane Central Register of Controlled Trials [CENTRAL], Web of Science, Embase, and PsycINFO) using the University of Plymouth’s search tool Primo, with slightly adjusted search terms to fit the specific structure of each database. The search terms were grouped into four themes joined in this structure: asthma (MeSH OR Keywords) AND asthma management (MeSH OR Keywords) AND children (MeSH OR Keywords) AND digital technology (MeSH OR Keywords). Multimedia Appendix 2 lists a complete record of the specific search terms and strings used for each database and the number of references returned. The database searches were completed on December 30, 2020, except for the CENTRAL database, which was searched on December 31, 2020.

The inclusion and exclusion criteria are shown in Textbox 2.

References were exported to the citation management software EndNote X9 (Clarivate Analytics) for storage and duplicate removal. Owing to the returning of the large number of references, an initial screening was conducted by inputting keywords relating to the inclusion and exclusion criteria into the EndNote X9 search function. This was done in several stages, with each subsequent screening being conducted on the subset of studies retrieved in the previous stage. For example, keywords relating to digital technologies were searched for in any field, and studies that did not contain at least one of those keywords were excluded. Subsequent searches used keywords to exclude studies that used terms unrelated to the topic (eg, cancer, diabetes, and enzyme). Multimedia Appendix 3 contains a full description of the searches conducted. Searches of keywords to exclude were based on common features of irrelevant studies that were identified in a manual search. The remaining titles and abstracts were screened by 2 reviewers (MMI and CL) independently (with articles excluded with reasons), and the final eligibility was determined by full-text reviews of the remaining references. Any discrepancies between the reviewers were discussed until a consensus was reached.

Outcomes were extracted by a reviewer (MMI) into a table structured according to the 3 research questions (Multimedia Appendix 4) and verified by a second reviewer (CL). Key outcomes were predetermined based on a preliminary review of the literature; however, because of the expected variety of reported outcomes, relevant outcomes that were not prespecified in the Population, Intervention, Comparator, Outcome, and Study framework or data extraction tables were also considered for inclusion in the final review (Textbox 3).

The data extracted from the studies about the key outcomes listed in Textbox 3 were assessed using descriptive analysis and summarized to provide an overview of the state of the literature. For outcomes related to effectiveness, the number of studies that found strong evidence of effectiveness was compared with the number of studies that assessed the outcome to provide a synthesis of the state of the evidence for that outcome. Implications of the findings were examined in the discussion.

A total of 6314 articles were retrieved from the search of the 5 databases (Multimedia Appendix 2). A total of 1029 duplicates were removed by the EndNote X9 software, and a further 5193 were screened using keyword searches in EndNote (Multimedia Appendix 3). The titles and abstracts of 92 studies were screened and articles were excluded with reasons. Of these articles, 25 were selected for full-text review, and 20 were selected for inclusion in the review. Of the total references, 6 referred to one study and were either conference abstracts or did not include the final results of the RCT. The paper with published results of the RCT of that study was identified and included [25]. Three references that only provided abstracts subsequently had full texts identified; these full texts were cited and used for data extraction and analysis. The reasons for exclusion in the full-text review stage are shown in Figure 1.

All the studies included in the review were RCTs and limited to those that included monitoring or adherence functions and aims. Despite these restrictions to the scope of the review, the included studies had a wide variety of study durations, sample sizes, age ranges, and types of digital intervention (Table 1).

Over a third of the references identified as eligible during title and abstract screening only had abstracts available (7/20, 35%) [31,35,36,39-42]. They were included in the analysis where relevant data were available; one of the abstracts only presented interim results [35]. Full texts were found for 3 of these 7 references [36,40,42], and data from those papers were used. A total of 4 studies were analyzed by 9 separate articles and abstracts: the ADolescent Adherence Patient Tool (ADAPT) study [25,33,34], a study comparing web-based Asthma Control Test and fractional exhaled nitric oxide monitoring with standard care [26,44], a study of inhaler electronic monitoring devices (EMDs) with audiovisual reminders [29,30], and a study of a real-time medication monitoring device with SMS text messaging reminders [31,43].

There was a wide range in study durations, from 3 weeks [32] to 24 months [27], with the most common length of follow-up being 6 or 12 months (n=4 [25,28-30,33,34,41] and n=3 studies [26,31,36,43,44] for each). There was also a wide range of numbers of participants included in the 15 studies, ranging from 22 [40] to almost 1200 [27], with an average of approximately 230 participants and a median of 209 [31,43].

There were no distinctive age categories that emerged from these studies. Of the 15 distinct studies, only 2 pairs used the same age range (4-11 years [31,38,43] and 6-16 years [36,42]). A total of 3 studies included adult participants, as well as child or adolescent participants [28,35,39]. The youngest participants included in the study were aged 3 years [27]. Of the studies that focused on participants under 18 years, the age range eligible for inclusion in each study ranged from 6 years (age 12-17 years [32]) to 15 years (age 4-18 years [26,44]).

A total of 4 studies took place across multiple centers [26,31,35,42-44], and most of the rest were associated with large medical centers [27,28,32,38] or clinics [36,41]. The remaining 5 studies were recruited from or associated with a hospital emergency department [29,30], community pharmacies [25,33,34], outpatient appointments in a hospital or Asthma Clinic [40], Howard University [39], and impoverished, rural school districts [37].

Various types of digital interventions for monitoring or improving medication adherence examined in the studies were included in this review (Table 1). The most common type of intervention, evaluated by a third of the studies (5/15, 33%), was EMDs. However, these EMDs varied in their features, which included audiovisual reminders [29,30], text messages [31,43], alarms [36], and app or web-based sources that could be synced to provide personal feedback [35,36], educational content [35], reminders [41], and capture adherence data [41].

Apps were another common intervention evaluated; 3 studies specifically evaluated three different app-based interventions. These included the ADAPT app that connects adolescents to their community pharmacist through a desktop application and enables them to monitor symptoms and adherence, chat with peers and their pharmacist, watch short educational movies, and set medication alarms [25,33,34]. Another app, CHANGE Asthma, was developed for children by 5 pediatricians and modified based on feedback from a pilot of 24 caregivers. It used short videos and games and an asthma action plan to improve asthma knowledge and control [38]. The third app evaluated (AsthmaWin) also included an asthma action plan but focused more on monitoring symptoms and medication adherence [39].

Other types of interventions evaluated included web-based monitoring programs [26,44] (one of which was a component of a Virtual Asthma Clinic [42]), a speech recognition automated telephone program to improve medication adherence [27], text message medication reminders [28], a website and text-based reminder system (MyMediHealth) [32], a remote directly observed therapy tool to improve inhaler use and adherence [40], and a school-based educational telemedicine intervention that provided interactive video sessions for children, caregivers, and school nurses [37].

Half of the studies included in the review (8/15, 53% of studies or 10/20, 50% of articles) did not explicitly discuss how the digital intervention they were evaluating was integrated with clinical care pathways [28-32,38-41,43]. A few studies described sending data from the interventions back to physicians to update the patients’ health records or inform care, although this potential would likely be feasible for many of them. For the few that did, integration of the intervention with the health care system was generally reported positively.

Even among those that described a specific link between the intervention and the health care system, the specific details about integration were not the primary focus of the paper. For instance, one study noted that the intervention was built into routine clinical care in the study and described how data could be uploaded to a website for patients, parents or caregivers, and clinicians to review adherence data together at appointments [36]. Some of the studies that monitored symptoms or adherence produced treatment advice based on data analysis from the system algorithms [26,44] or sent physicians warnings if a patient was out of a certain threshold [35]. The Virtual Asthma Clinic, which also sent feedback to physicians if a patient’s asthma control scores were low, was found to be successful in increasing asthma control and symptom-free days and was proposed by the authors as a partial replacement for outpatient visits [42]. Details of how these systems were integrated with the health care system have not been described.

One study whose intervention was significantly integrated with the health care system was the ADAPT app study [25,33,34]. One of the aims of the intervention was to increase collaboration and communication between adolescents and pharmacists because of the increasing role of pharmacists as health care providers in the Netherlands [25]. Pharmacists involved in the intervention reported valuing the improved contact with patients and found the intervention satisfactory, useful in fulfilling their role, and not time-consuming [34]. This contrasted with the perceptions of pharmacists who did not participate in the intervention, who identified time constraints as a barrier to the use of mobile health [34]. However, a barrier was identified because the stand-alone desktop interface of the ADAPT app for pharmacists was not integrated with the pharmacy’s general information system [34]. This study highlights the potential value of deliberate and considers efforts to integrate new digital health technologies for asthma management with existing health systems.

Speech recognition telemedicine intervention was another study that demonstrated integration with the health care system, which was integrated with the hospital’s electronic health record (EpicCare) to provide personalized calls to patients and is compatible with all standard electronic health record systems [27].

The attempt of one study [37] to involve primary care providers in the intervention was not successful. Treatment prompts with medication recommendations based on caregiver reports and guidelines were provided to the participants’ primary care providers. These were found to be ineffective; of the 141 prompts sent out for individual participants, the request for feedback received a response from only 1 primary care provider [37].

Different varieties of studies were examined in this review; the study duration ranged from 3 weeks to 2 years, the number of participants ranged from 22 to 1187, and although the review was focused on children and adolescents, the range of ages studied was wide, with no distinct age groups emerging from the studies. There were also several different types of digital interventions analyzed in the RCTs, with EMDs and mobile apps being the most common. Moreover, the integration of these technologies with existing clinical care pathways and health systems has not been extensively discussed in most studies.

The review found inconsistent evidence for the effectiveness of digital technologies in achieving their various aims. Most support was found for the effectiveness of the interventions in improving treatment or medication adherence (7/10, 70% of studies found significant evidence of effectiveness). The results of studies assessing the impact of the intervention on asthma control and health outcomes were mixed, with some studies reporting positive effects and others showing no significant effect. Across the studies, evaluations of patient perceptions, acceptability, and usability were generally positive. Only one study evaluated the cost-effectiveness of these solutions, but because of insignificant improvement in health outcomes, the intervention was not found to be cost-effective [31].

One limitation of this review is that a risk of bias assessment was not performed on the studies. Although this is not a standard requirement for scoping reviews, it is a limitation of the study, as it would have contributed to the assessment of the first research question by providing an analysis of the quality of the research being conducted on technologically supported asthma pathways.

Another limitation is that the research questions and aims were adjusted after the search was performed. They were changed before any screening or selection took place but may have resulted in relevant articles being missed because the search terms were established for a slightly different scope. Owing to time limitations, no manual searches of the references of reviews retrieved in the initial search were performed, which could have resulted in eligible articles being overlooked.

The large number of studies identified in the initial search and the variety of technological interventions to support pediatric asthma care demonstrate the broad scope of this research area. This review identified a few strong trends regarding how technologically supported asthma pathways for children and young people are being researched. The studies used a large range of sample sizes and participants of varying ages, which makes it difficult to make valid comparisons or conduct meta-analyses across different studies. A theoretical framework for determining what ages to study or how to stratify children and young people into age groups would be useful for the future. Currently, there is no consensus in the literature on how to group children of various ages for research, which is a significant limitation in the field.

This review found that there is a wide variety of digital interventions being explored. Although many of the studies examined reported positive results, strong evidence of their effectiveness in achieving various aims is still lacking. The strongest evidence was for improving treatment and medication adherence. However, the mixed evidence of asthma control, health, and quality of life outcomes suggests that there might be a disconnect between behavioral change and health outcomes. As asthma is a long-term condition, the study duration of included studies (from 3 weeks to 24 months) may not be long enough to observe significant health impacts, or there may be other factors influencing the relationship between treatment adherence and health outcomes (eg, technique). Understanding why this discrepancy was observed could help inform the design of more effective digital interventions and better study designs.

Another notable area that was missing from many of the studies was an assessment of the cost-effectiveness of the intervention. Considering that a key aim of many digital health technologies is to reduce the burden on health care systems by improving patient self-management, the benefit and cost of the intervention compared with the current standard of care is essential in the decision to integrate digital interventions into clinical care pathways. This will be a key area to consider for future evaluations of these technologies so that limited health care resources can be deployed to create the greatest value [45].

The overall findings are generally consistent with the previous reviews described in the Introduction section. Collectively, they identified at least some evidence of the benefits (depending on outcomes) of various digital health technologies on asthma-related outcomes [9-12,14]. One review also noted a lack of data regarding the cost-effectiveness of the digital asthma self-management interventions and patient perspectives [12]. This is also consistent with this review; patient perspectives were generally high when reported but were only examined in about a quarter (6/20, 30%) of the included studies.

Another key area for future research will be around the integration of these digital solutions into clinical pathways. As with cost-effectiveness, this review found that most studies did not explicitly consider or evaluate how the technology they were examining would interact with existing health systems. The potential benefit of integrating patient-reported data with patients’ health records to inform care plans and pathways is likely feasible for many of the technologies assessed but was not examined as a key outcome of the technology. Similarly, acceptability and usability data focused primarily on patient users. Understanding how these technologies can best support and interact with existing clinical pathways could help inform their design, improvement, and sustainable adoption.

The purpose of this scoping review was to summarize the literature on technologically enhanced asthma care pathways for children and young people. A large body of research is ongoing in this area and spans a wide range of technologies and ages. Although there was some evidence for the effectiveness of the digital interventions examined, particularly for improving treatment and medication adherence, further research is needed to establish the effectiveness of the interventions in improving asthma control and other health outcomes. This apparent discrepancy between significant evidence for behavior change and a lack of significant evidence for subsequent health impacts should be further examined, as it could indicate factors other than treatment adherence that affect health outcomes and could also be targeted for intervention. A couple of gaps in the literature were identified in terms of cost-effectiveness and integration with existing care pathways. Both of these aspects are essential for the successful adoption, scale-up, and sustained use of digital health interventions and are key areas for future research.